A5019520558- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Radiology practices and education
- Digital Radiography and Breast Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- RNA and protein synthesis mechanisms
- Effects of Radiation Exposure
- Cardiac Imaging and Diagnostics
- Glycosylation and Glycoproteins Research
- Radioactivity and Radon Measurements
- Medical Imaging Techniques and Applications
- Business, Innovation, and Economy
- Plant and animal studies
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Radiation Effects and Dosimetry
- Advances in Oncology and Radiotherapy
- Radiation Therapy and Dosimetry
- Business, Education, Mathematics Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Statistics Education and Methodologies
- Violence, Education, and Gender Studies
- Ocular and Laser Science Research
- Biochemical and Structural Characterization
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2015-2025
Universidad Complutense de Madrid
2014-2025
Hospital Clínico San Carlos
2015-2025
University of Pamplona
2016
Rockefeller University
1997-2006
Icahn School of Medicine at Mount Sinai
2006
International Centre for Genetic Engineering and Biotechnology
1995-1997
AREA Science Park
1997
Peking University
1997
New York University
1997
Seasonally dry tropical forests are distributed across Latin America and the Caribbean highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species woody plants, we show marked floristic turnover among regions, which may be higher other neotropical biomes, such as savanna. Such high indicates that numerous conservation areas countries will needed to protect full diversity forests. Our results provide a scientific...
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one-third of the human genome through a ‘copy and paste’ mechanism catalysed by its multifunctional enzyme, open reading frame 2 protein (ORF2p) 1 . ORF2p reverse transcriptase (RT) endonuclease activities have been implicated in pathophysiology cancer 2,3 , autoimmunity 4,5 ageing 6,7 making potential therapeutic target. However, lack structural mechanistic knowledge hampered efforts to...
Abstract The European Union Radiation, Education, Staffing & Training (EU-REST) study was a Commission-funded, 24-month project that analysed workforce availability, education and training needs to ensure quality safety aspects of medical applications involving ionising radiation in the EU developed staffing education/training guidelines for key professional groups involved ensuring Member States. This article outlines origin, development, goals overall structure project. Critical...
We evaluate homology-derived 3D models of dihydrofolate reductase (DFR1), phosphotransferase enzyme IIA domain (PTE2A3), and mouse/human UBC9 protein (UBC9(24)) which were submitted to the second Meeting on Critical Assessment Techniques for Protein Structure Prediction (CASP). The DFR1 PTE2A3 models, based alignments without large errors, slightly closer their corresponding X-ray structures than closest template structures. By contrast, UBC9(24) model was worse best due a misalignment...
The major a-amylase inhibitor (AAI) present in the seeds of Amaranthus hypocondriacus, a variety Mexican crop plant amaranth, is 32-residue-long polypeptide with three disulfide bridges.Purified AAI strongly inhibits activity insect larvae (12ibolium castaneum and Prostephanus truncatus) does not inhibit proteases mammalian a-amylases.AAI was sequenced automated Edman method, bridges were localized using enzymatic chemical fragmentation methods combined N-terminal sequencing.AAI shortest...
We have designed and expressed bivalent small immune proteins (SIP) based on scFv fragments connected through a short linker of four amino acids to the CH3 domain human immunoglobulin gamma 1 H-chain. Three different versions been in mammalian cells. In one construct cysteine residue was included last acid flexible 15-amino long connecting V(L) V(H) domains, thus creating disulphide bond stabilized molecule. A version with shorter (five acids) V(L)/V(H) also produced shown be efficiently...
The penalty for inserting gaps into an alignment between two protein sequences is a major determinant of the accuracy. Here, we present algorithm finding globally optimal by dynamic programming that can use variable gap (VGP) function any form. We also describe specific depends on structural context insertion or deletion. It penalizes are introduced within regions regular secondary structure, buried regions, straight segments and spatially distant residues. parameters were optimized set 240...
<h3>BACKGROUND AND PURPOSE:</h3> Radiation exposure from neurointerventional procedures can be substantial, with risk of radiation injuries. We present the results a follow-up program applied to potential skin injuries in interventional neuroradiology based on North American and European guidelines. <h3>MATERIALS METHODS:</h3> The following guidelines approved 2009 by SIR CIRSE have been used over last 2 years identify patients requiring clinical follow-up: peak dose >3 Gy, air kerma at...
Journal Article Influence of dosemeter position for the assessment eye lens dose during interventional cardiology Get access Sara Principi, Principi 1Institut de Tècniques Energètiques, Universitat Politècnica Catalunya (UPC), Barcelona 08028, Spain Search other works by this author on: Oxford Academic PubMed Google Scholar Mercè Ginjaume, Ginjaume * *Corresponding author: merce.ginjaume@upc.edu Maria Amor Duch, Duch Roberto M. Sánchez, Sánchez 2Medical Physics, Hospital Clínico San Carlos,...
Journal Article Measurements of eye lens doses in interventional cardiology using OSL and electronic dosemeters Get access R. M. Sanchez, Sanchez * 1Medical Physics, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Madrid, Spain *Corresponding author: robertomariano.sanchez@salud.madrid.org Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Vano, Vano Spain2Radiology Department, Faculty Medicine, Universidad Complutense J. Fernandez,...
In 2011, the International Commission on Radiologic Protection established an absorbed-dose threshold to brain of 0.5 Gy as likely produce cerebrovascular disease. this paper, authors investigated doses delivered patients during clinical neuroradiology procedures in a university hospital.The radiation dose was 99 diagnostic and therapeutic interventional procedures. Brain were calculated mathematic model adult standard anthropomorphic phantom by using technical data x-ray biplane system...
The purpose of this work is to evaluate radiation doses the lens urologists during interventional procedures and compare them with values measured radiology, cardiology vascular surgery. measurements were carried out in a surgical theatre using mobile C-arm system electronic occupational dosimeters (worn over lead apron). Patient staff dose collected sample 34 urology interventions (nephrolithotomies). same dosimetry was used other medical specialties for comparison purposes. Median 3rd...
Abstract Objectives The radiology industry has been developing advanced X-ray systems which now deliver high-quality imaging while reducing radiation exposure. In this study, we analyse the impact of new on patient and occupational doses, compared with previous ones (from same manufacturer). Methods A dose management system (DMS) was employed to large datasets from interventional cardiology procedures assess protection improvements. Interventionists wear electronic active dosimeters...
Interventional fluoroscopic guided cardiac procedures lead to radiation exposure the lenses of eyes cardiologists, which over time may be associated with an increased risk cataracts. This study derives doses lens eye in catheterization laboratories from measurements individual allow for estimates such those cases when personal dosimeters have not been used regularly. Using active electronic at C-arm (at 95 cm isocenter), scatter measured and estimated cardiologists different groups...
The purpose of this article is to estimate lens doses using over apron active personal dosemeters in interventional catheterisation laboratories (cardiology IC, neuroradiology IN and radiology IR) investigate correlations between occupational patient doses. Active electronic placed the lead were used on a sample 204 IC procedures, 274 220 IR (all performed at same university hospital). Patient dose values (kerma area product) also recorded evaluate with Operators ceiling-suspended screen...
The International Commission on Radiological Protection recommends that occupational protection and patient be managed in an integrated approach. This paper describes the experience initial results of a system able to register process simultaneously staff doses interventional cardiology practical use this optimisation exposure. used collects manages for all radiation events. personal electronic dosimeters worn over protective apron health professionals working inside catheterisation...
Objectives: Radiation dose management systems (DMS) are currently used to help improve radiation protection in medical imaging and interventions. This study presents our experience using a homemade DMS called DOLQA (Dose On-Line for Quality Assurance). Methods: Our is connected 14 X-ray university hospital linked the central data repository of large network 16 public hospitals Autonomous Community Madrid, with 6.7 million inhabitants. The system allows us manage individual patient groups...