A5074785169- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Toxoplasma gondii Research Studies
- Long-Term Effects of COVID-19
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Multisensory perception and integration
- SARS-CoV-2 detection and testing
- Visual perception and processing mechanisms
- Mosquito-borne diseases and control
- Neuroscience and Music Perception
- Pluripotent Stem Cells Research
- Single-cell and spatial transcriptomics
- Innovation and Socioeconomic Development
- CRISPR and Genetic Engineering
King's College London
2020-2024
Guy's Hospital
2020-2021
Universidade de São Paulo
2016-2020
University of Sheffield
2017
COVID-19 vaccine design and vaccination rollout need to take into account a detailed understanding of antibody durability cross-neutralizing potential against SARS-CoV-2 emerging variants concern (VOCs). Analyses convalescent sera provide unique insights longevity activity induced by variant spike proteins, which are putative candidates. Using from 38 individuals infected in wave 1, we show that can be detected up 305 days pos onset symptoms, although were less potent B.1.1.7 (Alpha) B1.351...
Toxoplasmosis is caused by the parasite Toxoplasma gondii that can infect central nervous system (CNS), promoting neuroinflammation, neuronal loss, neurotransmitter imbalance and behavioral alterations. T. infection also related to neuropsychiatric disorders such as schizophrenia. The pathogenicity inflammatory response in rodents are different case of humans, compromising correlation between alterations physiological modifications observed disease. In present work we used BrainSpheres, a 3D...
As SARS-CoV-2 variants continue to emerge globally, a major challenge for COVID-19 vaccination is the generation of durable antibody response with cross-neutralizing activity against both current and newly emerging viral variants. Cross-neutralizing concern (B.1.1.7, P.1 B.1.351) has been observed following vaccination, albeit at reduced potency, but whether vaccines based on Spike glycoprotein these will produce superior not fully investigated. Here, we used sera from individuals infected...
The role of myeloid cells in the pathogenesis SARS-CoV-2 is well established, particular as drivers cytokine production and systemic inflammation characteristic severe COVID-19. However, potential for to act bona fide targets productive infection, specifics entry, remain unclear. Using a panel anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed detailed assessment antibody-mediated infection monocytes/macrophages. mAbs with most consistent mediate were those targeting conserved region...
ABSTRACT Background Toxoplasmosis is caused by the parasite Toxoplasma gondii that can infect central nervous system (CNS), promoting neuroinflammation, neuronal loss, neurotransmitter imbalance and behavioral alterations. T . infection also related to neuropsychiatric disorders such as schizophrenia. The pathogenicity inflammatory response in rodents are different case of humans, compromising correlation between alterations physiological modifications observed disease. In present work we...