Acacia hydaspica R. Parker, family leguminosae, is a medicinally important plant. Different plant parts are used in various ailments folk medicine. The current study aimed at investigating the vitro antioxidant, anti-hemolytic and anticancer activity of A. hydaspica. Antioxidant potential was assessed using DPPH, ABTS •OH, scavenging H2O2, inhibition lipid peroxidation β-carotene bleaching assays. Anti-hemolytic H2O2 induced hemolysis RBCs. Anticancer MTT assay. Spectrometric methods...

PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects quercetin in letrozole induced rat model polycystic ovarian syndrome, which displayed both clinical metabolic features as women. Female Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution carboxymethyl (CMC 0.5%); administered with (1 mg/kg) dissolved Metformin...

Acacia hydaspica R. Parker is known for its medicinal uses in multiple ailments. In this study, we performed bioassay-guided fractionation of cytotoxic compounds from A. and investigated their effects on growth signaling activity prostate breast cancer cell lines. Four active polyphenolic were identified as 7-O-galloyl catechin (GC), (C), methyl gallate (MG), catechin-3-O-gallate (CG). The four inhibited PC-3 a dose-dependent manner, whereas CG MG MDA-MB-231 growth. All tested survival...

Inflammation and pain underlies several pathological conditions. Synthetic drugs used for the management of these conditions carry severe toxic effects. Globally efforts are ongoing to introduce novel medicinal plants develop effective, economic innocuous drugs. The current study was aimed at investigating antipyretic, anti-inflammatory analgesic activity methanol extract A. hydaspica aerial parts (AHM) its active fraction. Furthermore identification isolation polyphenolic compounds carried...

Green synthesis of metal nanoparticles using plant extracts as capping and reducing agents for the biomedical applications has received considerable attention. Moreover, emergence spread multidrug resistance among bacterial pathogens become a major health concern lookout novel alternative effective drugs gained momentum. In current study, we synthesized gold seed extract Trachyspermum ammi (TA-AuNPs), assessed its efficacy against drug resistant biofilms Listeria monocytogenes Serratia...

New approaches for the prevention of colon cancer perseveres an essential necessity. Though, resistance to existing chemo-preventive drugs is moderately predominant in carcinogenesis. Taxifolin (dihydroquercetin) a flavononol, have shown virile biological activities against few cancers. The current study was designed investigate and equate antitumor activity (TAX) colorectal cell lines HCT116 xenograft model comprehensive approach.Two human HT29, were used. 3-(4, 5-dimethylthiazol-2-yl)-2,...

Doxorubicin (DOX) is an anthracycline drug used for cancer treatment. However, its treatment contiguous with toxic effects. We examined the nephroprotective potential of A. hydaspica polyphenol-rich ethyl acetate extract (AHE) against DOX persuaded nephrotoxicity. 36 male Sprague Dawley rats were randomly assorted into 6 groups. Control group received saline; group: 3 mg/kg b.w. dosage intraperitoneally weeks (single dose/week). In co-treatment groups, 200 and 400 b.w AHE was given orally in...

Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess favorable effects Rutin against metabolic, biochemical, histological, and androgenic aspects polycystic rats.Female Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period 21 days induction PCOS, followed by dose rutin (100 mg/kg 150 mg/kg, p.o) 15 using 0.5% w/v CMC as vehicle. Metformin also given standard control one rat...

Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating protective effect A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and injuries in rats. Rats were divided into six groups (n = 6). Group I (control), group II (CP single dose on day 16). III received AHE for 21 days. IV + AHE; post- treatment group). V (AHE CP; pre-treatment group) VI Sily). CP reduced...

Cisplatin (CP) or cis-diammine dichloroplatinum (II) is a platinum based standard antineoplastic drug which used against variety of solid tumors and neoplasms. The present study aimed to evaluate the shielding effects rutin CP induced testicular toxicity in rats. 28 male rats were divided into four groups. First group was given saline orally while second received intra-peritoneal (i.p) injection cisplatin (7 mg/kg) on day first for next 13 days. Third i.p at one treated with (75 Fourth...

Doxorubicin (DOX) is an anthracycline agent mostly prescribed for various cancers. However, its treatment contiguous with toxic effects. Acacia hydaspica prevented drug-induced hepatic-toxicity in animals anti-oxidative mechanisms. We intended to study the efficacy of A. ethyl acetate extract (AHE) inhibiting DOX- induced liver damage.Normal control group received saline; Drug 3 mg/kg b.w. dose DOX 6 weeks (single dose/week, intraperitoneal injection) effect chronic treatment. In...

Bisphenol A (BPA) is a monomer primarily used in the production of polycarbonate plastic and epoxy resins. F (BPF) apparently main BPA replacement that increasingly. BPF has been detected canned food, thermal paper receipts, soft drinks. In present experiment, we did both vitro vivo studies to evaluate effect low high-dose exposures on testosterone concentration, oxidative stress, antioxidants activity reproductive tissues male rats.Adult (80-90 days old) Sprague Dawley rats (n = 36)...

Cadmium (Cd) is a highly toxic heavy metal that can be found everywhere in the environment and have harmful effects on both human animal health. Pinostrobin (PSB) bioactive natural flavonoid isolated from Boesenbergia rotunda with several pharmacological properties, such as antiinflammatory, anticancer, antioxidant, antiviral. This investigation was intended to assess therapeutic potential of PSB against Cd-induced kidney damage rats.In total, 48 Sprague Dawley rats were divided into four...

Acacia hydaspica belongs to family leguminosae possess antioxidant, anti-inflammatory and anticancer activities. During our search for antioxidant compounds from A. hydaspica, we carried out bioassay guided fractionation obtained with free radical scavenging activity.The polyphenol in the plant extract of were isolated by combination different chromatographic techniques involving vacuum liquid chromatography medium pressure chromatography. The structural heterogeneity was characterized high...

Vitamin D can influence more than 200 genes in various tissues showing its credibility among the fat-soluble vitamins. deficiency is directly proportional to major clinical conditions such as cardiovascular diseases, diabetes, malignancy, and multiple sclerosis. This study was conducted determine vitamin level of individuals association with depression.

Low and middle-income countries are facing a rapid increase in obesity overweight burden, particularly urban settings. Being men is associated with infertility higher risk to have low sperm count or no their ejaculate. Despite potential limitations, this one of few studies conducted determine the paternal on standard parameters, chromatin integrity assisted conception outcome including fertilization, embryo quality, cleavage rate, reduce blastocyst development, implantation, cumulative live...

The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause DOX induced cardiotoxicity. We have investigated whether polyphenol rich ethyl acetate extract Acacia hydaspica (AHE) can attenuate doxorubicin-induced cardiotoxicity via inhibition oxidative stress.AHE was administered orally rats once daily for 6 weeks at doses 200 and 400 mg/kg b.w. (3 i.p., single dose/week)...

PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries the key diagnostic feathers. The study was undertaken to investigate possible protective ameliorating effects of GABA in Letrozole induced PCOS model rats by targeting insulin resistance.PCOs Adult female rat daily gastric administration letrozole (1 mg/kg/day) CMC (0.5%) for 36 days. Rats were given...

Abstract Background More than the two decades, question of whether vitamin D has a role in cancer frequency, development, and death been premeditated detail. Colorectal, breast, prostate cancers have scrupulous spot center, altogether, these three malignancies report for approximately 35% cases 20% demises United States, as such are chief public health apprehension. The aim was to evaluate antitumor activity Vitamin D-Nanoemulsion (NVD) colorectal cell lines HCT116 xenograft model...

Abstract Background Polycystic Ovary Syndrome (PCOS) affects a significant proportion of human females worldwide and is characterized by hormonal, metabolic, reproductive dysfunctions, including infertility, irregular menstrual cycles, acanthosis nigricans, hirsutism. Mutations in the estrogen receptor genes ESR1 ESR2 , involved normal follicular development ovulation, can contribute to PCOS. The present study focuses on investigating potential correlation between single nucleotide...

Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica a natural shrub with pharmacological properties. The current investigation aimed assess protective potential A. polyphenol rich ethyl acetate extract (AHE) against cisplatin induced pulmonary toxicity.Rats were divided into six groups. Group 1 served as control (saline); 2 (drug control) recieved single dose (7.5 mg/kg...

Myrin®-p Forte is an anti-tuberclosis agent that can cause hepatic injuries in clinical settings. Maytenus royleanus (Celastraceae) a medicinal plant, possesses antioxidant and anticancer activities. The hepatoprotective effect of the methanol extract leaves (MEM) against induced hepatotoxicity mice was investigated.Mice were randomly parted into six groups (n = 6). Fixed-dose combination (13.5 mg/kg Rifampicin, 6.75 Isoniazid, 36.0 Pyrazinamide 24.8 Ethambutol; RIPE] administered for 15...

Abstract Arsenic is one of the most hazardous environmental contaminants, which adversely affects dynamics male reproductive system. Fisetin (FIS) a bioactive flavonoid, known to exert strong antioxidative effects. Therefore, current research was planned evaluate alleviative efficacy FIS against arsenic-induced damages. Forty-eight albino rats were divided into 4 groups (n = 12), treated as follows: (1) Control, (2) Arsenic-intoxicated group (8 mg kg −1 ), (3) + FIS-treated 10 and (4) (10...

Viral hepatitis is the major contributor to liver cirrhosis and hepatocellular carcinoma (HCC). Studies indicated that co-infection of C B virus also prompts damage progression. Therefore, in present study, prevalence HCV-HBV impact on progression was evaluated amongst HCV-infected patients Pakistan. In this study 2500 HCV-positive were recruited from The presence HCV HBV confirmed through ELISA nested PCR. To determine due viral infection levels ALT, ALP, total bilirubin determined....