A5013586965- Genetic and Kidney Cyst Diseases
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Renal and related cancers
- Epigenetics and DNA Methylation
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
- Genetic Syndromes and Imprinting
- Urological Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Genomics and Chromatin Dynamics
- Bone Metabolism and Diseases
- Hippo pathway signaling and YAP/TAZ
- TGF-β signaling in diseases
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- 14-3-3 protein interactions
- Tissue Engineering and Regenerative Medicine
- Genetics and Neurodevelopmental Disorders
- Hemispheric Asymmetry in Neuroscience
- Kruppel-like factors research
Medizinische Hochschule Hannover
2009-2025
Institute of Molecular Biology
2025
Mount Sinai Hospital
2004
Max Planck Institute for Molecular Genetics
2004
Max Planck Institute for Biophysical Chemistry
2004
Lunenfeld-Tanenbaum Research Institute
2004
In the mammalian ureters, lamina propria presents as a prominent layer of connective tissue underneath urothelium. Despite its important structural and signaling functions, little is known how develops. Here, we show that in murine ureter, arises at late fetal stages massively increases by fibrocyte proliferation collagen deposition after birth. WNT, SHH, BMP4 retinoic acid are all active common mesenchymal progenitor smooth muscle cells fibrocytes. However, around birth, becomes target for...
The mouse homeobox gene Noto represents the homologue of zebrafish floating head (flh) and is expressed in organizer node nascent notochord. Previous analyses suggested that required exclusively for formation caudal part Here, we show also essential morphogenesis, controlling ciliogenesis posterior notochord, establishment laterality, whereas functions anterior-posterior patterning are apparently not compromised. In mutant embryos, left-right asymmetry internal organs expression laterality...
The floating head ( flh ) gene in zebrafish encodes a homeodomain protein, which is essential for notochord formation along the entire body axis. orthologs, termed Not genes, have been isolated from chick and Xenopus , but no mammalian ortholog has yet identified. Truncate tc an autosomal recessive mutation mouse that specifically disrupts development of caudal notochord. Here, we demonstrate truncate arose by gene. allele contains point homeobox changes conserved Phenylalanine residue helix...
The mouse transcription factor Noto is expressed in the node and controls morphogenesis, formation of nodal cilia left-right asymmetry. acts upstream Foxj1, which regulates ciliogenesis other tissues. However, significance Foxj1 for unclear; non-amniote species required structures equivalent to node. Here, we analyzed nodes, flow embryos replaced Noto-coding sequence with that or were deficient Foxj1. We show from locus functional restores structurally normal motile absence Noto. not...
Cilia are complex cellular protrusions consisting of hundreds proteins. Defects in ciliary structure and function, many which have not been characterised molecularly, cause ciliopathies: a heterogeneous group human syndromes. Here, we report on the FOXJ1 target gene Cfap206, orthologues so far only studied Chlamydomonas Tetrahymena In mouse Xenopus, Cfap206 was co-expressed with dependent Foxj1 CFAP206 protein localised to basal body axoneme motile cilia. Xenopus crispant larvae, beat...
The transcription factor FOXJ1 is essential for the formation of motile cilia throughout animal kingdom. Target genes therefore likely constitute an important part program. Here, we report on analysis one these targets, Fam183b, in Xenopus and mice. Fam183b encodes a protein with unknown function which conserved from green algae Chlamydomonas to humans. expressed tissues harbouring both mouse frog embryos. FAM183b localises basal bodies mIMCD3 cells multiciliated larval epidermis. In...
Abstract Cilia are protrusions of the cell surface and composed hundreds proteins many which evolutionary functionally well conserved. In cells assembling motile cilia expression numerous ciliary components is under control transcription factor FOXJ1. Here, we analyse conserved FOXJ1 target CFAP161 in Xenopus mouse. both species Cfap161 correlates with presence depends on Tagged localises to basal bodies multiciliated larval epidermis, mice protein axoneme. Surprisingly, disruption gene did...
Etl4(lacZ) (Enhancer trap locus 4) and Skt(Gt) (Sickle tail) are lacZ reporter gene integrations into the same on mouse chromosome 2 targeting a that is expressed in notochord of early embryos multiple epithelia during later development. Both insertions caused recessive mutations resulted exclusively mild defects caudal vertebral column. Since notochord-derived signals essential for formation column phenotypes suggested interfered with some notochord-dependent aspect As both occurred introns...
The mouse transcription factor Noto is expressed in the node and controls morphogenesis, formation of nodal cilia left-right asymmetry. acts upstream Foxj1, which regulates ciliogenesis other tissues. However, significance Foxj1 for unclear; non-amniote species required structures equivalent to node. Here, we analyzed nodes, flow embryos replaced Noto-coding sequence with that or were deficient Foxj1. We show from locus functional restores structurally normal motile absence Noto. not...