A5044230079- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Transplantation: Methods and Outcomes
- Vascular Procedures and Complications
- Mechanical Circulatory Support Devices
- Capital Investment and Risk Analysis
- Electron and X-Ray Spectroscopy Techniques
- Monetary Policy and Economic Impact
- Advanced X-ray and CT Imaging
- Integrated Circuits and Semiconductor Failure Analysis
- Cardiac and Coronary Surgery Techniques
- Cardiac Health and Mental Health
- Lipoproteins and Cardiovascular Health
- Coronary Artery Anomalies
- Financial Reporting and Valuation Research
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
Erasmus MC
2018-2024
Erasmus University Rotterdam
2018-2022
Coronary plaques that are prone to rupture and cause adverse cardiac events characterized by large plaque burden, lipid content, thin fibrous caps. Statins can halt the progression of coronary atherosclerosis; however, effect proprotein convertase subtilisin kexin type 9 inhibitor alirocumab added statin therapy on burden composition remains largely unknown.To determine effects atherosclerosis using serial multimodality intracoronary imaging in patients with acute myocardial infarction.The...
Stent underexpansion increases the risk of cardiac adverse events. At present, there are limited options to treat refractory stent underexpansion. In this context, intravascular lithotripsy (IVL) system might be a safe and effective strategy.We aimed evaluate safety efficacy IVL in addressing resistant due heavy underlying calcification.This was an international multicentre registry including patients receiving therapy from December 2017 August 2020. Angiographic intracoronary imaging data...
Post–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) <0.90 is common and has been related to impaired patient outcome. The authors sought evaluate if PCI optimization directed by intravascular ultrasound (IVUS) in patients with post-PCI FFR could improve 1-year target vessel failure (TVF) rates. In this single-center, randomized, double-blind trial, a at the time of angiographically successful were randomized IVUS-guided or standard care (control arm). primary endpoint...
Background: Fractional flow reserve (FFR) after percutaneous coronary intervention is a predictor of adverse cardiovascular events during follow-up. However, the rationale for low post procedural FFR values remains often elusive based on angiographic findings alone. Methods and Results: SEARCH (Stent Evaluated at Rotterdam Cardiology Hospital) prospective single-center registry in which post-percutaneous was assessed 1000 consecutive all-comer patients. measurements were performed with...
A 74-year old man with history of hypertension and dyslipidaemia, presented Class III angina. Coronary angiography showed a right dominant system heavily calcified stenotic lesion in the proximal left anterior descending (LAD) coronary artery minimal lumen diameter 1.15mm stenosis 63% by quantitative angiography. [...]
Abstract Stent underexpansion is frequently observed in calcified coronary lesions and increases the risk of future adverse cardiac events. Current plaquemodification techniques might not be suitable when calcium deposition circumferential deep inside vessel wall. We report a case during which lithoplasty was used as an adjuvant therapy to improve severe stent after failed atherectomy high‐pressure non‐compliant balloon dilatations.
Abstract Objectives We aimed to evaluate the feasibility of using three dimensional‐quantitative coronary angiography (3D‐QCA) based fractional flow reserve (FFR) (vessel [vFFR], CAAS8.1, Pie Medical Imaging) and correlate vFFR values with intravascular ultrasound (IVUS) for evaluation intermediate left main artery (LMCA) stenosis. Background 3D‐QCA derived FFR indices have been recently developed less invasive functional lesion assessment. However, LMCA lesions were vastly under‐represented...
Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm automatically quantify coronary calcifications on intravascular ultrasound (IVUS). aimed assess the prognostic value of IVUS-calcium score (ICS) patient-oriented composite endpoint (POCE).We included patients that underwent angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. primary a all-cause mortality, stroke, myocardial infarction, revascularization...
Stent thrombosis (ST) is a rare but potentially fatal complication of coronary artery stenting. Little known about the optimal treatment strategy at time an ST event. We aimed to identify incidence and predictors adverse cardiac events after definite ST.A total 695 patients with were included between 1996 2017 in two academic medical centres. The primary endpoint was MACE, composite death, myocardial infarction (MI) target vessel revascularisation (TVR). Mean age 62.8±12.1 years 76.3% male....
Positive near-infrared spectroscopy (NIRS) signals might be encountered in areas without evident artery wall thickening, being typically perceived as artefacts.We aimed to evaluate the utility of NIRS identify regions associated with an increase thickness (WT) assessed by serial intravascular ultrasound (IVUS) and optical coherence tomography (OCT).In this prospective, single-centre study, patients presenting acute coronary syndrome (ACS) underwent NIRS-IVUS OCT assessment a non-culprit at...
Abstract Objectives To assess the performance of commercially available Magmaris sirolimus‐eluting bioresorbable scaffold (BRS) with invasive imaging at different time points. Background Coronary BRS a magnesium backbone have been recently studied as an alternative to polymeric scaffolds, providing enhanced vessel support and faster resorption rate. We aimed Methods A prospective, single‐center, nonrandomized study was performed Thoraxcenter, Erasmus Medical Center, Rotterdam, The...
Aims: Bioresorbable scaffold (BRS) regions exposed to flow recirculation, low time-averaged wall shear stress (TAWSS) and high oscillatory index (OSI) develop increased neointima tissue.We investigated haemodynamic features in four different BRSs.Methods results: Fantom (strut height [SH] = 125 µm), Encore (SH 98 Absorb 157 µm) Magmaris 150 BRSs were deployed phantom tubes imaged with microCT.Both 2D 3D geometrical models reconstructed.Computational fluid dynamics (CFD) simulation was...
Abstract Background Angiographic assessment of left main coronary artery (LMCA) lesions remains challenging and limited data is available on reference diameters length nonobstructive LMCA dimensions. Our aim was to provide insights in the dimensions find a possible correlation with gender patient habitus. Methods This retrospective single center study performed consecutive cohort patients who underwent Intravascular Ultrasound (IVUS) guided percutaneous interventions system including...
Abstract Objective and background The study aim is to provide long‐term clinical outcome after percutaneous coronary intervention (PCI) for unprotected left main arteries (ULMCA) stenosis with the first‐generation (1 st ‐gen) drug‐eluting stents (DES) in comparison 2 nd ‐gen DES, since this largely unknown. Methods Between May 2002, December 2014, a consecutive series of 656 all‐comer patients underwent PCI ULMCA at Erasmus Medical Center. A total 235 were treated 1 while 421 DES. Results...
Introduction and objectives:Patients with a low post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) are at higher risk for future adverse cardiac events.The objective of the current study was to assess specific patient procedural predictors post-PCI FFR.Methods: The FFR-SEARCH is prospective single-center registry 1000 consecutive all-comer patients who underwent FFR measurements after an angiographically successful PCI dedicated microcatheter.Mixed effects models...
Abstract Aims There is a paucity of data on the performance angiography-derived vessel fractional flow reserve (vFFR) in coronary artery lesions patients presenting with non-ST-segment elevation acute syndrome (NSTE-ACS). Optical coherence tomography (OCT) allows for visualization lumen dimensions and plaque integrity high resolution. The aim this study was to define association between vFFR OCT findings intermediate NSTE-ACS. Methods results FAST prospective, multicenter, single-arm study....