A5039333980- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Venous Thromboembolism Diagnosis and Management
- Semiconductor materials and devices
- Spectroscopy Techniques in Biomedical and Chemical Research
- Lipoproteins and Cardiovascular Health
- Electron Spin Resonance Studies
- Magnetic Properties of Alloys
- Renal and Vascular Pathologies
- Capital Investment and Risk Analysis
- Healthcare cost, quality, practices
- Financial Reporting and Valuation Research
- Artificial Intelligence in Healthcare and Education
- Infective Endocarditis Diagnosis and Management
Erasmus MC
2019-2025
Erasmus University Rotterdam
2020-2023
Massachusetts General Hospital
2020
Post–percutaneous coronary intervention (PCI) fractional flow reserve (FFR) <0.90 is common and has been related to impaired patient outcome. The authors sought evaluate if PCI optimization directed by intravascular ultrasound (IVUS) in patients with post-PCI FFR could improve 1-year target vessel failure (TVF) rates. In this single-center, randomized, double-blind trial, a at the time of angiographically successful were randomized IVUS-guided or standard care (control arm). primary endpoint...
Background: Fractional flow reserve (FFR)-guided treatment has been demonstrated to improve percutaneous coronary intervention (PCI) results. However, little is known on the long-term impact of low post-PCI FFR. Methods: This a large prospective all comers study evaluating FFR clinical outcomes. All patients undergoing successful PCI were eligible for enrollment. measurements performed immediately after when operator considered angiographic result acceptable and final. No further action was...
New permanent pacemaker implantation (new-PPI) remains a compelling issue after Transcatheter Aortic Valve Replacement (TAVR). Previous studies reported the relationship between short MS length and new-PPI post-TAVR with self-expanding THV. However, this has not been investigated in different currently available Therefore, aim of study was to investigate association membranous septum (MS)-length TAVR Heart (THV)-platforms.We included patients successful TAVR-procedure an analyzable...
Vessel Fractional Flow Reserve (vFFR) as assessed by three-dimensional quantitative coronary angiography has high correlation with pressure wire-based fractional flow reserve in both a pre- and post-PCI setting. The present study aims to assess the prognostic value of vFFR on incidence target vessel failure (TVF), composite endpoint cardiac death, myocardial infarction revascularization (TVR) at 5-year follow up.Post-PCI was calculated after routine PCI total 748 patients (832 vessels)...
ABSTRACT Background Fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) can be used to evaluate procedural success and guide stent optimization. Several studies have demonstrated that lower FFR after implantation is associated with increased adverse event rates up 2 years. However, the impact of post‐PCI on very long‐term clinical outcome remains unknown. Methods The SEARCH study a single‐center, prospective, observational including consecutive patients...
Coronary calcification represents a challenge in the treatment of coronary artery disease by stent placement. It negatively affects expansion and has been related to future adverse cardiac events. Intravascular ultrasound (IVUS) is known for its high sensitivity detecting calcification. At present, automated quantification calcium as detected IVUS not available. For this reason, we developed validated an optimized framework accurate detection calcified plaque atherosclerosis seen IVUS....
Dedicated prospective studies investigating high-definition intravascular ultrasound (HD-IVUS)-guided primary percutaneous coronary intervention (PCI) are lacking. The aim of this study was to qualify and quantify culprit lesion plaque characteristics thrombus using HD-IVUS in patients presenting with ST-segment elevation myocardial infarction (STEMI).The SPECTRUM is a prospective, single-center, observational cohort the impact HD-IVUS-guided PCI 200 STEMI (NCT05007535). first 100 de novo...
Abstract Objectives We aimed to evaluate the feasibility of using three dimensional‐quantitative coronary angiography (3D‐QCA) based fractional flow reserve (FFR) (vessel [vFFR], CAAS8.1, Pie Medical Imaging) and correlate vFFR values with intravascular ultrasound (IVUS) for evaluation intermediate left main artery (LMCA) stenosis. Background 3D‐QCA derived FFR indices have been recently developed less invasive functional lesion assessment. However, LMCA lesions were vastly under‐represented...
3D coronary angiography-based vessel fractional flow reserve (vFFR) proved to be an accurate diagnostic alternative invasively measured pressure wire based (FFR). The ability compute post-PCI vFFR using pre-PCI virtual stent analysis is unknown. We aimed assess the feasibility and accuracy of stenting (residual vFFR) with FFR as a reference. This observational, single-center retrospective cohort study including consecutive patients from FFR-SEARCH registry. blindly calculated residual...
Abstract Background Severe coronary artery calcification is associated with stent underexpansion and subsequent failure. Aims We aimed to identify optical coherence tomography (OCT)‐derived predictors of absolute (minimal area [MSA]) relative expansion in calcified lesions. Methods This retrospective cohort study included patients who underwent percutaneous intervention (PCI) OCT assessment before after implantation between May 2008 April 2022. Pre‐PCI was used assess calcium burden post‐PCI...
Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm automatically quantify coronary calcifications on intravascular ultrasound (IVUS). aimed assess the prognostic value of IVUS-calcium score (ICS) patient-oriented composite endpoint (POCE).We included patients that underwent angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. primary a all-cause mortality, stroke, myocardial infarction, revascularization...
Introduction Intravascular ultrasound (IVUS) improves clinical outcome in patients undergoing percutaneous coronary intervention (PCI) but dedicated prospective studies assessing the safety and efficacy of IVUS guidance during primary PCI are lacking. Methods analysis The SPECTRUM study is a investigator-initiated single-centre single-arm observational cohort aiming to enrol 200 presenting with ST-segment elevation myocardial infarct IVUS-guided PCI. will be performed at baseline,...
Thrombolysis in Myocardial Infarction (TIMI) 0 flow often characterizes ST-segment Elevation (STEMI) patients, but may also feature non-ST-segment Acute Coronary Syndrome (NSTE-ACS). Since recanalization usually occurs later NSTE-ACS the aim of this study was to assess whether patients presenting with and TIMI have worse clinical outcomes as compared STEMI flow.
Complete revascularization in patients with ST-segment elevation myocardial (STEMI) improves clinical outcome. Vessel fractional flow reserve (vFFR) has been validated as a non-invasive physiological technology to evaluate hemodynamic lesion significance without need for dedicated pressure wire or hyperemic agent. This study aimed assess discordance between vFFR reclassification and treatment strategy intermediate non-culprit lesions of STEMI the impact this discordance.This was...
Recently, non-hyperemic pressure ratios (NHPRs) have been validated as a reliable alternative to fractional flow reserve (FFR). However, discordance between FFR and NHPRs is observed in 20-25% of cases. The aim this study evaluate predictors diastolic Pressure ratio (dPR).PREDICT retrospective, single center, investigator-initiated including 813 patients (1092vessels) who underwent assessment intermediate coronary lesions (angiographic 30%-80% stenosis). dPR was calculated using individual...