A5067708877- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Healthcare Policy and Management
- Immunotherapy and Immune Responses
- Patient Satisfaction in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Cancer, Stress, Anesthesia, and Immune Response
- CNS Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Diabetes and associated disorders
- Bladder and Urothelial Cancer Treatments
- T-cell and Retrovirus Studies
- Musculoskeletal synovial abnormalities and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
Columbia University Irving Medical Center
2020-2025
China Medical University Hospital
2025
China Medical University
2025
Columbia University
2023-2024
New York Hospital Queens
2024
NewYork–Presbyterian Hospital
2024
Roswell Park Comprehensive Cancer Center
2013-2024
Stanford University
2008
T-cell trafficking at vascular sites has emerged as a key step in antitumour immunity. Chemokines are credited with guiding the multistep recruitment of CD8+ T cells across tumour vessels. However, multiplicity chemokines within tumours obscured contributions individual chemokine receptor/chemokine pairs to this process. Moreover, recent studies have challenged whether require receptor signalling effector sites. Here we investigate hierarchy requirements during murine and human melanoma....
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is MDSC-mediated immunosuppression restricted tissues where MDSC co-mingle with cells. Here we show splenic or, unexpectedly, blood-borne execute far-reaching immune suppression reducing expression of the L-selectin lymph node (LN) homing receptor on naïve and B MDSC-induced loss occurs through a contact-dependent,...
OBJECTIVES. With >6 million hospital stays, costing almost $50 billion annually, hospitalized children represent an important population for which most inpatient quality indicators are not applicable. Our aim was to develop using administrative data assess aspects of the pediatric care and access outpatient care. METHODS. We adapted Agency Healthcare Research Quality indicators, a publicly available set measurement tools refined previously by our team, population. systematically...
Purpose While surgical resection is a cornerstone of cancer treatment, local and distant recurrences continue to adversely affect outcome in significant proportion patients. Evidence that an alternative debulking strategy involving radiofrequency ablation (RFA) induces antitumor immunity prompted the current investigation efficacy performing RFA prior (pre-resectional RFA) preclinical mouse model. Experimental Design Therapeutic systemic immune responses were assessed following...
There is no standard of care in relapsed/refractory T-cell/natural killer-cell lymphomas. Patients often cycle through cytotoxic chemotherapy (CC), epigenetic modifiers (EM) or small molecule inhibitors (SMI) empirically. Ideal therapy at each line remains unknown. We conducted a retrospective, multiple intervention, 'target-trial' using the PETAL global cohort. received front-line CC, then second and third (2L 3L) with either CC again, EM SMI (12 possible treatment scenarios). Overall...
SUMMARY Immune responses to respiratory viruses like SARS-CoV-2 originate and function in the lung, yet assessments of human immunity are often limited blood. Here, we conducted longitudinal, high-dimensional profiling paired airway blood samples from patients with severe COVID-19, revealing immune processes tract linked disease pathogenesis. Survival was associated increased CD4 + T cells decreased monocyte/macrophage frequencies airway, but not Airway macrophages exhibited tissue-resident...
Respiratory failure in COVID-19 is characterized by widespread disruption of the lung's alveolar gas exchange interface. To elucidate determinants lung damage, we performed epithelial and immune cell profiling lungs from 24 autopsies 43 uninfected organ donors ages 18-92 years. We found marked loss type 2 (T2AE) cells increased perialveolar lymphocyte cytotoxicity all fatal cases, even at early stages before typical patterns acute injury are histologically apparent. In donors, there was also...
Background: Surgery, chemotherapy, and radiation often have limited utility for advanced metastatic disease in the liver, despite its promising activity select cancers, PD-1 blockade therapy similarly has minimal benefit this setting. Curaxin, CBL0137, is an experimental anti-cancer drug that disrupts binding of DNA to histones, destabilizes chromatin, induces Z-DNA formation which may stimulate anti-tumor immune responses. Methods: Murine cell lines colon (CT26) breast (4T1) cancer were...
Autoantigen-specific immunotherapy using peptides offers a more targeted approach to treat autoimmune diseases, but clinical implementation has been challenging. We previously showed that multivalent delivery of as soluble antigen arrays (SAgAs) efficiently protects against spontaneous diabetes in the non-obese diabetic (NOD) mouse model. Here, we compared efficacy, safety, and mechanisms action SAgAs versus free peptides. SAgAs, not their corresponding at equivalent doses, prevented...
Abstract The success of immunotherapy and, unexpectedly, chemotherapy and radiation hinges on cytotoxic T cells gaining access to tumor targets. These observations have prompted interest in developing strategies improve cell trafficking tumors. Here, we report that the ability vessels respond IL-6-dependent preconditioning regimens boost CD8 effector homing is temporally inversely related expansion myeloid-derived suppressor (MDSC) within microenvironment. Using real-time intravital imaging...