A5083044227- Neuroendocrine Tumor Research Advances
- Vasculitis and related conditions
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Thyroid Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Pancreatic and Hepatic Oncology Research
- Sarcoidosis and Beryllium Toxicity Research
- Peptidase Inhibition and Analysis
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- IgG4-Related and Inflammatory Diseases
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Thyroid and Parathyroid Surgery
- Brain Metastases and Treatment
- Alzheimer's disease research and treatments
- Medical Imaging and Pathology Studies
University Hospital of Basel
2015-2024
University College London
2018-2021
Hospital Base
2019-2021
University of Basel
2015-2020
University Medical Center Freiburg
2009-2020
Klinik und Poliklinik für Nuklearmedizin
2007-2020
Ryhov Hospital Jönköping
2018
University College London Hospitals NHS Foundation Trust
2018
County Hospital
2018
The Royal Free Hospital
2018
<sup>111</sup>In-DOTA-exendin-4 SPECT/CT has been shown to be highly efficient in the detection of insulinomas. We aimed at determining whether novel PET/CT imaging with [Nle<sup>14</sup>,Lys<sup>40</sup>(Ahx-DOTA-<sup>68</sup>Ga)NH<sub>2</sub>]exendin-4 (<sup>68</sup>Ga-DOTA-exendin-4) is feasible and sensitive detecting benign <b>Methods:</b><sup>68</sup>Ga-DOTA-exendin-4 were performed a randomized cross-over order on 5 patients endogenous hyperinsulinemic hypoglycemia. The gold standard...
PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the early diagnosis dementia follow-up patients dementia. We investigated validity relative CBF estimates (R(1)) gained from pharmacokinetic analyses (11)C-labeled Pittsburgh compound B ((11)C-PIB) as a marker neurodegeneration.Twenty-two cognitive impairment (16 Alzheimer disease) underwent (18)F-FDG (11)C-PIB...
Treatment of patients with advanced medullary thyroid carcinoma (MTC) is still a challenge. For more than 2 decades, it has been known that the cholecystokinin receptor promising target for treatment MTC radiolabeled minigastrin analogs. Unfortunately, kidney toxicity precluded their therapeutic application so far. In 6 consecutive patients, we evaluated 3-dimensional dosimetry whether improved analog <sup>177</sup>Lu-DOTA-(d-Glu)<sub>6</sub>-Ala-Tyr-Gly-Trp-Nle-Asp-PheNH<sub>2</sub>...
Abstract Objectives To assess changes of arterial vessel wall morphology in large GCA patients (LV-GCA) by repeated US. Methods Patients with LV-GCA on US examination were followed up 6, 12 and 24 months after diagnosis the temporal, vertebral, carotid (common, internal, external), subclavian, axillary, femoral (deep, superficial common) popliteal arteries. Clinical laboratory data assessed at each visit. Vessel thickening was classified as moderate, marked or arteriosclerotic. Results A...
Patients with metastatic medullary thyroid cancer (MTC) have limited systemic treatment options. The use of radiolabeled gastrin analogs targeting the cholecystokinin-2 receptor (CCK2R) is an attractive approach. However, their therapeutic efficacy presumably decreased by enzymatic degradation in vivo. We aimed to investigate whether chemically stabilized analog <sup>177</sup>Lu-DOTA-PP-F11N (<sup>177</sup>Lu-DOTA-(dGlu)<sub>6</sub>-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH<sub>2</sub>) performs better...
Abstract Objectives [18F]Fluorodeoxyglucose (FDG)-PET/CT and US are both well established for diagnosing GCA. The present study investigates their accuracy whether they provide overlapping or complementary information in a cohort of patients presenting with suspicion Methods We selected consecutive from our suspected GCA cases that underwent extended vascular PET/CT diagnostic work-up between December 2006 August 2012. Results A total 102 were included. Diagnosis was confirmed 68 excluded 34...
Surgery with curative intent can be offered to congenital hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled exendin-4 specifically binds glucagonlike peptide 1 receptor on pancreatic β-cells. In this study, we compared performance of 18F-DOPA PET/CT, current standard imaging method for CHI, and PET/CT new tracer 68Ga-NODAGA-exendin-4 in preoperative detection focal CHI. Methods: Nineteen CHI patients underwent both before surgery. The images were evaluated 3...
The usefulness of [18F] fluorodeoxyglucose-positron emission tomography/computed tomography ([18F]FDG-PET/CT) for diagnosing giant cell arteritis (GCA) has been previously reported. Yet, the interpretation PET scans is not clear-cut. present study aimed at determining best method to analyse PET/CT in a large, real-life cohort patients presenting with suspicion GCA.One hundred and three clinical GCA undergoing between 2006 2012 were included. Clinical data retrieved from patients' charts. was...
Abstract Background A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due less enzymatic degradation. Nevertheless, tumor in patients indicate limited stability humans. We aimed at evaluating the effect sacubitril, an inhibitor neutral endopeptidase 1, on absorbed tumors organs by cholecystokinin-2 receptor agonist [ 177 Lu]Lu-PP-F11N patients. In this prospective phase 0 study eight consecutive with advanced...
The aim of the study was comparison C-11 methionine (MET) and choline (CHO) in positron emission tomography (PET) imaging brain metastases correlation to histopathology findings stereotactic biopsy.In all, 8 patients underwent MET CHO PET magnetic resonance imaging, 7 these, were previously treated by radiation therapy. Histopathologic diagnosis made for each patient frame-based serial biopsy. Standardized uptake values tumor lesion-to-normal tissue ratios (LNRs) lesions determined. LNRs...
Purpose Physiological pancreaticoduodenal uptake of radiolabeled exendin-4 in Brunner glands the proximal duodenum is most common pitfall for false interpretation glucagon-like peptide-1 receptor (GLP-1R) imaging. The aim this study was to analyze GLP-1R PET/CT and SPECT/CT images identify additional potential reading pitfalls patients with suspected insulinoma. Methods A post hoc analysis a prospective study, including 52 consecutive patients, performed. All underwent 1 68 Ga-exendin-4 2...
To describe the feasibility and diagnostic accuracy of 18F-FDG positron emission tomography-computed tomography (PET/CT) temporal artery compared with ultrasound histology in patients suspicion having giant cell arteritis (GCA).Patients suspected GCA were included. PET/CT standard uptake value ratios compression sign on assessed for trunk, parietal frontal branches artery. Temporal biopsies systematically re-assessed, if available.In 17/34 patients, was confirmed. confirmed vasculitis 9/17...
The number of circulating clonotypic B cells in patients with multiple myeloma (MM) after high‐dose therapy (HDT) peripheral blood stem cell transplantation (PBSCT) was investigated. Peripheral CD19 + have been reported to persist throughout conventional and HDT might resemble a source relapse MM. We assessed the proportion malignant CD20 fractions 14 (PB) samples from 12 PBSCT. Nine were obtained continuous remission, five progressive disease or beginning relapse. had mean purity 96.8%....
A long-acting somatostatin analogue (lanreotide) is used in the management of a diazoxide-unresponsive diffuse form congenital hyperinsulinism (CHI). However, no reports its use patients with focal CHI exist. Case 1: 1-month-old boy diagnosed due to paternal heterozygous ABCC8 gene mutation showed partial response octreotide. 18F-DOPA-PET/CT scan revealed lesion pancreatic head. Surgical removal was unsuccessful. He switched monthly lanreotide treatment at age 11 months, which stabilised his...
To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas.F-18 DOPA examinations were performed 9 patients with 7 4 head neck paragangliomas using a dedicated scanner. The acquisition started dynamic single-bed tumor region over first 60 minutes after tracer injection followed by late whole-body at approximately 130 minutes. Standard uptake values (SUVs) calculated tumors, surrounding...
Radio-iodinated metaiodobenzylguanidine ((123)I-MIBG) is used for the detection and staging of neuroblastoma, pheochromcytoma other neuroendocrine tumours in diagnostic nuclear medicine. A specific uptake storage mechanism provides basis imaging with (123)I-MIBG. Nevertheless, cases false-positive (123)I-MIBG scintigraphy accumulation non-chromaffin have been described. Here, we present a case scan mast-cell infiltrated infantile haemangioma discuss possible mechanism.
Chediak-Higashi syndrome (CHS) is a rare autosomal-recessive lysosomal storage disorder caused by mutations of the trafficking regulator gene ( LYST ) on chromosome 1q42. The disease characterized partial oculocutaneous albinism, immunodeficiency, peroxidase-positive granules in leukocytes and giant other tissues (e.g., neurons, astrocytes), neurologic disturbances. There are two distinct clinical patterns. In childhood form, hematologic system affected with frequent bacterial infections, an...