A5001665110- Fungal Biology and Applications
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Pneumonia and Respiratory Infections
- Asthma and respiratory diseases
- Education and Learning Interventions
- Blood Coagulation and Thrombosis Mechanisms
- Liver Diseases and Immunity
- Antibiotics Pharmacokinetics and Efficacy
- Immune Cell Function and Interaction
- Plant Reproductive Biology
- Cardiovascular Health and Disease Prevention
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Analytical Chemistry and Chromatography
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Vasculitis and related conditions
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Phytochemical compounds biological activities
- Immunodeficiency and Autoimmune Disorders
- Sarcoidosis and Beryllium Toxicity Research
Hokkaido University
2022-2024
Nihon University
2007-2024
Azabu University
2021-2024
Kobe College
2024
Nagoya City University
2024
Aichi Gakuin University
2024
University of Technology Sydney
2023
Ohta Nishinouchi Hospital
2006-2022
Kyorin University
1989-2022
Fujita Health University Hospital
2021
To study the relation between diurnal blood pressure variations and silent cerebrovascular damage, we performed both 24-hour ambulatory monitoring brain magnetic resonance imaging in 131 elderly asymptomatic hypertensive patients. Silent damage was identified by findings of lacunae (low intensity T1-weighted images high T2-weighted images) advanced periventricular hyperintense lesions (on images). The frequency 100 patients with sustained hypertension greater than that 31 white coat...
In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Oral medication demands not only high activity but also target specificity, favorable bioavailability, and metabolic stability. Although a large number compounds have been identified potential inhibitors SARS-CoV-2 infection in vitro, few proven be effective vivo....
We aimed to define the clinical features of liver dysfunction in patients with systemic lupus erythematosus (SLE).The frequency and causes were examined 206 SLE.Liver was evident 123 (59.7%) patients. Liver SLE can be drug-induced (30.9%) or caused by itself (28.5%), fatty (17.9%), autoimmune hepatitis (AIH) (4.9%), primary biliary cirrhosis (2.4%), cholangitis (1.6%), alcohol (1.6%) viral (0.8%), it tends mild except when AIH. Values for aminotransferase significantly increased AIH cause,...
Objectives To collect clinical information and NOD2 mutation data on patients with Blau syndrome to evaluate their prognosis. Methods Fifty mutations were analysed. The activity of each mutant was evaluated in HEK293 cells by reporter assay. Clinical collected from medical records through the attending physicians. Results study population comprised 26 males 24 females aged 0–61 years. Thirty-two cases sporadic, 18 familial 9 unrelated families. Fifteen different identified, including 2 novel...
Bacterial genomic DNA, plasmid DNA (pDNA) and synthetic oligodeoxynucleotides (ODN) containing immunostimulatory sequences (ISS) have been proposed to foster a Th1 response via the release of type 1 cytokines from macrophages, dendritic cells, NK cells B cells. In this study, we show that ISS-enriched up-regulates distinct profile cell surface molecules on macrophages in vitro vivo. ISS-ODN ISS-containing pDNA enhanced expression antigen presentation (MHC class I II), co-stimulatory (B7-1,...
Theiler's murine encephalomyelitis virus (TMEV) infection and relapsing‐remitting experimental allergic (R‐EAE) have been used to investigate the viral autoimmune etiology of multiple sclerosis (MS), a possibleTh1‐type mediated disease. DNA immunization is novel vaccination strategy in which few harmful effects reported. Bacterial oligodeoxynucleotides, contain CpG motifs, reported enhance immunostimulation. Our objectives were two‐fold: first, ascertain whether plasmid DNA, pCMV, widely as...
Pulmonary infection with SARS-CoV-2 stimulates host immune responses and can also result in the progression of dysregulated critical inflammation. Throughout pandemic, management treatment COVID-19 has been continuously updated a range antiviral drugs immunomodulators. Monotherapy oral antivirals proven to be effective COVID-19. However, should initiated early stages ensure beneficial therapeutic outcomes, there is still room for further consideration on strategies using antivirals.
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae ), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for better understanding of the pathogenesis these validation antiviral agents Yezo (YEZV), novel orthonairovirus causing febrile illnesses associated with tick...
Introduction Food questionnaire surveys are often used to evaluate masticatory function. In daily clinical practice in Japan, a survey is performed using list of food groups suitable for the Japanese diet. The foods on were categorized into five based their mastication index. patient's function determined by that can be eaten. index, which indicates chewability, was defined percentage 110 denture wearers who responded they could eat normally. A with this useful because its simplicity;...
SummaryBackground and aimsThe Enhanced Recovery after Surgery (ERAS) program has been proposed as a postoperative recovery-enhancing strategy. We frequently apply the Modified-ERAS following oesophagectomy. This study aims to elucidate impact of goal-directed fluid therapy (GDT) for perioperative management oesophageal cancer on recovery patients undergoing oesophagectomy.MethodsThis is an interventional before-after comparative observational conducted at Kanagawa Cancer Centre, Japan....
Most members of the genus Gammacoronavirus infect avian hosts, but far fewer viruses have been characterized than in other coronavirus genera, leaving their diversity largely unclear. Pigeon gammacoronaviruses were previously detected by consensus PCR, only partial sequences determined. In this study, we comprehensively analyzed public RNA-seq datasets and reconstructed two nearly complete genomes pigeon gammacoronaviruses. Molecular evolutionary analyses showed belong to subgenus...
A guanine nucleotide-specific RNase (RNase Po1) was isolated from caps of the fruit bodies Pleurotus ostreatus. Po1 is most active towards RNA at pH 8.0. The effect heating on molar ellipticity 210 nm showed that more stable than T1. primary structure determined to be < ETGVRSCNCAGRSFTGTDVTNAIRSARAGGSGNYPHVYNNFEGFSFSCTPTFFEFPVFRGSVYSGGSPG ADRVIYD- QSGRFCACLTHTGAPSTNGFVECRF. It consisted 101 amino acid residues, with a molecular weight 10,760. has relatively higher sequence homology T1 family...
The complete primary structure of a base non-specific and adenylic acid preferential RNase (RNase Le2) from the fruit bodies Lentinus edodes was analyzed. sequence mostly determined by analysis peptides generated V8 protease digestion BrCN cleavage (including α-chymotryptic, digest fragments). It consists 239 amino residues. molecular weight is 25831. location 10 half cystine residues were almost superimposable on those known fungal RNases T2 family. homologies between Le2 four family, T2,...
Hepatitis B virus (HBV) reactivation has been increasingly recognized in patients receiving chemotherapy and immunosuppressive therapy; however, the prevalence of HBV infection rate screening with rheumatic diseases remains unclear. In this study, we aimed to assess fulminant hepatitis diseases. We also investigated before therapy A retrospective questionnaire survey was conducted North-east area (Tohoku) Japan. Questionnaires, comprising 6 questions, were sent 318 rheumatologists May 2010,...
Abstract In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Oral medication demands not only high activity but also target specificity, favorable bioavailability, and metabolic stability. Although a large number compounds have been identified potential inhibitors SARS-CoV-2 infection in vitro , few proven...
The aim of this study was to determine the frequency heparin/platelet factor (PF) 4 complex antibodies in 305 uremic patients treated with chronic intermittent hemodialysis using unfractionated heparin or low-molecular-weight for 3 months. Heparin-induced thrombocytopenia (HIT) were detected by ELISA 7 (2.3%) who had no history HIT. Two abruptly developed HIT associated formation clots extracorporeal circuit after they found be carrying antibodies. These suspected have a similar trigger: an...
Abstract Background Breast augmentation has been linked to various complications, including cancerous tumors. The majority type of breast cancer associated with is adenocarcinoma. Primary squamous cell carcinoma (SCC) the extremely rare in both augmented and non-augmented women. Due low incidence, possible origin mechanism carcinogenesis SCC are not well understood. Here, we report a case pure 16 years after liquid silicone injection. Case presentation A 51-year-old Japanese woman was...
We investigated the imbalance between thrombin and plasmin activity in vivo with various grades of severity disseminated intravascular coagulation (DIC) relation to underlying diseases. Plasma thrombin-antithrombin-III complex (TAT) plasmin- &#913;<sub>2</sub>-antiplasmin (PAP) levels were measured 133 blood samples obtained from patients DIC. The TAT/PAP ratio was higher sepsis or solid cancer than those hematologic malignancies. In acute promyelocytic leukemia (APL), TAT...
The applicability of monitoring concentrations serum KL-6 and surfactant protein-D (SP-D) in the detection methotrexate-associated lung injury (MTX pneumonitis) patients with rheumatoid arthritis (RA) was investigated. these markers, sequentially measured two RA complicated MTX pneumonitis, were increased accordance severity pneumonitis. Conversely, markers decreased improvement suggesting that could be applicable not only for detecting onset but also therapeutic response...