A5054531499- Particle physics theoretical and experimental studies
- Dark Matter and Cosmic Phenomena
- HIV Research and Treatment
- Cosmology and Gravitation Theories
- Immune Cell Function and Interaction
- Particle Detector Development and Performance
- High-Energy Particle Collisions Research
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Black Holes and Theoretical Physics
- Neutrino Physics Research
- Quantum Chromodynamics and Particle Interactions
- Atomic and Subatomic Physics Research
- T-cell and B-cell Immunology
- Bartonella species infections research
- Hepatitis C virus research
- Distributed and Parallel Computing Systems
- Rabies epidemiology and control
- Fungal Infections and Studies
- Streptococcal Infections and Treatments
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Glycosylation and Glycoproteins Research
- Computational Physics and Python Applications
- Astrophysics and Cosmic Phenomena
The University of Melbourne
2016-2025
ARC Centre of Excellence for Dark Matter Particle Physics
2020-2025
Brooke Army Medical Center
2008-2022
Joint Base San Antonio
1993-2022
ARC Centre of Excellence for Particle Physics at the Terascale
2015-2021
Belfast Health and Social Care Trust
2019
Yale University
2016
SLAC National Accelerator Laboratory
2014-2015
Menlo School
2014-2015
Rutgers, The State University of New Jersey
2011-2015
Segmental duplications in the human genome are selectively enriched for genes involved immunity, although phenotypic consequences host defense unknown. We show that there significant interindividual and interpopulation differences copy number of a segmental duplication encompassing gene encoding CCL3L1 (MIP-1alphaP), potent immunodeficiency virus-1 (HIV-1)-suppressive chemokine ligand HIV coreceptor CCR5. Possession lower than population average is associated with markedly enhanced...
Peripheral blood mononuclear cells (PBMCs) from many asymptomatic individuals infected with human immunodeficiency virus-type 1 (HIV) are unresponsive as measured by in vitro T cell proliferation and interleukin-2 (IL-2) production to influenza virus synthetic peptides of HIV envelope (Env). Strong virus- Env-stimulated IL-2 responses were restored when cultures stimulated the presence IL-12. Interferon-gamma PBMCs seropositive (HIV+) patients was also Furthermore, antigen-specific HIV-...
Durable control of human immunodeficiency virus (HIV) replication and lack disease progression in the absence antiretroviral therapy were studied a military cohort 4586 subjects. We examined groups elite controllers (ie, subjects with plasma HIV RNA levels <50 copies/mL; prevalence, 0.55% [95% confidence interval {CI}, 0.35%–0.80%]), viremic 50–2000 3.34% CI, 2.83%–3.91%]), long-term nonprogressors [LTNPs]) through 7 years follow-up (LTNP7s; 3.32% 2.70%–4.01%]) or 10 (LTNP10s; 2.04%...
We present the physics program of Belle II experiment, located on intensity frontier SuperKEKB $e^+e^-$ collider. collected its first collisions in 2018, and is expected to operate for next decade. It anticipated collect 50/ab collision data over lifetime. This book outcome a joint effort collaborators theorists through theory interface platform (B2TiP), an that commenced 2014. The aim B2TiP was elucidate potential impacts program, which includes wide scope topics: B physics, charm, tau,...
We show that the new measurement of effective number neutrinos (Neff) by Planck satellite can be used to set a robust lower bound on mass cold thermal dark matter (MeV). Our limit applies if remains in equilibrium coupling electrons and photons or through interactions with neutrinos, regardless whether annihilation cross-section is s-wave p-wave. To illustrate our bounds we apply them model supersymmetric neutralino annihilating via light mixed left-right handed sneutrino mediator. While...
This document a outlines set of simplified models for dark matter and its interactions with Standard Model particles. It is intended to summarize the main characteristics that these have when applied searches at LHC, provide number useful expressions reference. The list includes both s-channel t-channel scenarios. For s-channel, spin-0 spin-1 mediations are discussed, also realizations where Higgs particle provides portal between visible sectors. guiding principles underpinning proposed...
Dark matter interacting via the exchange of a light pseudoscalar can induce observable signals in indirect detection experiments and experience large self-interactions while evading strong bounds from direct dark searches. The mediator will however flavour-changing interactions Standard Model, providing promising alternative way to test these models. We investigate detail constraints arising rare meson decays fixed target for different coupling structures between Model fermions. resulting...
In the original version of this manuscript, an error was introduced on pp352. '2.7nb:1.6nb' has been corrected to '2.4nb:1.3nb' in current online and printed version. doi:10.1093/ptep/ptz106.
Abstract We improve the current upper bound on axion-photon coupling derived from stellar evolution using R 2 parameter, ratio of populations Asymptotic Giant Branch to Horizontal in Globular Clusters. compare this with data simulations code MESA which include effects axion production. Particular attention is given quantifying detail uncertainties and parameters due modelling convective core boundaries. Using a semiconvective mixing scheme we constrain be g aγγ < 0.47 × 10 -10 GeV -1 ....
Objective: To describe a clinical syndrome of cat scratch disease caused by Rochalimaea henselae, including methods for isolation the organism from tissue and identification. Design: Case series. Setting: U.S. Air Force referral hospital infectious diseases clinic. Patients: Two previously healthy patients. Main Measurements Results: immunocompetent patients who had handled cats developed unilateral upper-extremity adenitis associated with distal papular lesion fever. The lesions persisted...
Studies in humans and experimental models of HIV-1 infection indicate an important role for monocyte chemoattractant protein-1 (MCP-1; also known as CC chemokine ligand 2), a potent activator mononuclear phagocytes (MP) the pathogenesis HIV-associated dementia (HAD). We determined influence genetic variation MCP-1 on large cohorts HIV-1-infected adults children. In adults, homozygosity –2578G allele was associated with 50% reduction risk acquiring HIV-1. However, once established, this same...
Genetic variation in CC chemokine receptor 5 ( CCR5 ), the major HIV-1 coreceptor, has been shown to influence transmission and disease progression. However, it is generally assumed that same genotype (or haplotype) similar phenotypic effects different populations. To test this assumption, we used an evolutionary-based classification of haplotypes determine their associated disease-modifying a large well-characterized racially mixed cohort HIV-1-seropositive individuals. We demonstrate...
Journal Article Relapsing Illness Due to Rochalimaea henselae in Immunocompetent Hosts: Implication for Therapy and New Epidemiological Associations Get access Daniel Lucey, Lucey From the Departments of Medicine Pathology, Wilford Hall U.S. Air Force Medical Center, Lackland Base, Texas; Analytical Chemistry Laboratory Special Bacterial Reference Laboratory, Meningitis Pathogens Branch, Division Mycotic Diseases, Center Infectious Centers Disease Control, Atlanta, Georgia; Roche Molecular...
Expression of CC chemokine receptor 5 (CCR5), the major coreceptor for HIV-1 cell entry, and its ligands (e.g., RANTES MIP-1α) is widely regarded as central to pathogenesis infection. By surveying nearly 3,000 HIV+ HIV− individuals from worldwide populations polymorphisms in genes encoding RANTES, MIP-1α, CCR5, we show that evolutionary histories human have had a significant impact on distribution variation these genes, this may be responsible, part, heterogeneous nature epidemiology...
Originally recognized for their role in lipoprotein metabolism and cardiovascular disease, apolipoprotein (apo) E isoforms (apoE2, apoE3, apoE4) have also been implicated to play a key several biological processes not directly related lipid transport function. For example, apoE4 contributes significantly neurodegeneration Alzheimer's disease. However, the of apoE infectious diseases is less well defined. Here, by examining large cohort HIV(+) European African American subjects, we found that...
Loss of CD4+ T cells, the hallmark HIV pathogenesis, was suggested to be partly due apoptosis. We recently reported that IFN-alpha produced by HIV-1-activated plasmacytoid dendritic cells (pDCs) contributes cell apoptosis TNF-related apoptosis-inducing ligand (TRAIL)/death receptor (DR)5 pathway. Here, we show HIV-1-induced intracellular expression in pDCs is coupled increased IFN regulatory factor 7 and MyD88 vivo vitro. Expression lymphoid tonsillar tissue (LT) patients with progressive...
We study the validity of effective field theory (EFT) interpretations monojet searches for dark matter at LHC vector and axial-vector interactions. show that EFT approach is valid when mediator has mass m_med greater than 2.5 TeV. find current limits on contact interaction scale Lambda in apply to theories are perturbative m_DM < 800 GeV. However, all values these theories, width larger mass, so a particle-like interpretation doubtful. Furthermore, consistency with thermal relic density...
We introduce a Minimal Simplified Dark Matter (MSDM) framework to quantitatively characterise dark matter (DM) searches at the LHC. study two MSDM models where DM is Dirac fermion which interacts with vector and axial-vector mediator. The are characterised by four parameters: m , M med g q, mediator masses, couplings quarks respectively. accurately capture full event kinematics, dependence on all masses can be systematically studied. interpretation of mono-jet in this used establish an...