A5070009738- Malaria Research and Control
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Microbial Natural Products and Biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- 14-3-3 protein interactions
- Chemical Thermodynamics and Molecular Structure
- Genomics and Phylogenetic Studies
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Diverse Scientific Research Studies
- RNA Interference and Gene Delivery
- GABA and Rice Research
- Radioactive element chemistry and processing
- Metal complexes synthesis and properties
- Parkinson's Disease Mechanisms and Treatments
- Nanocluster Synthesis and Applications
- vaccines and immunoinformatics approaches
- Diet and metabolism studies
- Protease and Inhibitor Mechanisms
- Photosynthetic Processes and Mechanisms
- Venomous Animal Envenomation and Studies
- Synthesis and Characterization of Heterocyclic Compounds
Jawaharlal Nehru University
2018-2023
National Institute of Immunology
2016-2023
The NorthCap University
2023
University of Nebraska–Lincoln
2015
Rates of nucleotide substitution were previously shown to be several times slower in the plastid inverted repeat (IR) compared with single-copy (SC) regions, suggesting that IR provides enhanced copy-correction activity. To examine generality this synonymous rate dependence on IR, we plastomes from 69 pairs closely related species representing 52 families angiosperms, gymnosperms, and ferns. We explored breadth boundary shifts land plants demonstrate rates are, average, 3.7 genes than SC...
Abstract DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored mechanism of through protamine-DNA interaction, and by examining on influence binding drugs. We observed that accompanied B to Ψ-DNA transition as result base pair distortions due protamine binding, bringing about formation toroidal structure coil-globule transition. The energetics suggested electrostatic energy, bending energy hydration must play...
Recent advanced studies in neurodegenerative diseases have revealed several links connecting autophagy and neurodegeneration. Autophagy is the major cellular degradation process for removal of toxic protein aggregates responsible diseases. More than 30 autophagy-related proteins been identified as directly participating process. Proteins regulating are much more numerous unknown. To address this, our present study, we a novel regulator (ARL6IP5) neuronal showed that level ARL6IP5 decreases...
In biological systems, the unprompted assembly of DNA molecules by cationic ligands into condensed structures is ubiquitous. The ability to provoke packaging crucial molecular organization and functional control DNA, yet their underlined physical roles have remained elusive. Here, we examined condensation mechanism four ligands, including primary DNA-binding modes through extensive biophysical studies. We observed contrasting changes for these binding poly[dGdC]:poly[dGdC] (GC-DNA)...
Upon Plasmodium falciparum merozoites exposure to low [K+] environment in blood plasma, there is escalation of cytosolic [Ca2+] which activates Ca2+-Dependent Protein Kinase 1 (CDPK1), a signaling hub intra-erythrocytic proliferative stages parasite. Given its high abundance and multidimensional attributes parasite life-cycle, this lucrative target for designing antimalarials. Towards this, we have virtually screened MyriaScreenII diversity collection 10,000 drug-like molecules, resulted 18...
Misfolding and aggregation of cellular prion protein is associated with a large array neurological disorders commonly called the transmissible spongiform encephalopathies. Designing inhibitors against prions has remained daunting task owing to limited information about mechanism(s) their pathogenic self-assembly. Here, we explore anti-prion properties combinatorial library bispidine-based peptidomimetics (BPMs) that conjugate amino acids hydrophobic aromatic side chains. Keeping bispidine...
Aminoacyl tRNA synthetases are central enzymes required for protein synthesis. These the known drug targets in bacteria and fungi. Here, we first time report functional characterization of threonyl synthetase (LdThrRS) Leishmania donovani, a protozoan parasite, primary causative agent visceral leishmaniasis.Recombinant LdThrRS (rLdThrRS) was expressed E. coli purified. The kinetic parameters rLdThrRS were determined. subcellular localization done by immunofluorescence analysis. Heterozygous...
Scaffold proteins play pivotal role as modulators of cellular processes by operating multipurpose conformation clamps. 14-3-3 are gold-standard scaffold modules that recognize phosphoSer/Thr (pS/pT) containing conserved motifs, and confer conformational changes leading to modulation functional parameters their target proteins. Modulation in activity kinases has been attributed interaction with Herein, we have annotated characterized PF3D7_0818200 isoform I Plasmodium falciparum 3D7, its one...
The HEP II (Heparin-binding site II) region of fibronectin (FN) containing domain III14 plays a crucial role in cell adhesion and migration through heparin-binding on the surface. There are two such heparin interacting peptide (FHIP I FHIP sequences present II. However, molecular principles by which these sites orchestrate processes poorly understood. Such knowledge would have great implications therapeutic targeting FN. With this aim, we explored binding studies with using various...
Apicomplexan parasites, through their motor machinery, produce the required propulsive force critical for host cell-entry. The conserved components of this so-called glideosome machinery are myosin A and Tail Interacting Protein (MTIP). MTIP tethers to inner membrane complex parasite 20 amino acid-long C-terminal end that makes direct contacts with MTIP, allowing invasion Plasmodium falciparum in erythrocytes. Here, we discovered screening a peptide library, de-novo ZA1 binds tail domain. We...
Abstract Upon Plasmodium falciparum merozoites exposure to low [K + ] environment in blood plasma, there is escalation of cytosolic [Ca 2+ which activates Ca -Dependent Protein Kinase 1 (CDPK1), a signaling hub intra-erythrocytic proliferative stages parasite. Given its high abundance and multidimensional attributes parasite life-cycle, this lucrative target for desiging antimalarials. Towards this, we have virtually screened MyriaScreenII diversity collection 10,000 drug-like molecules,...
ABSTRACT Scaffold proteins play pivotal role as modulators of cellular processes by operating multipurpose conformation clamps. 14-3-3 are gold-standard scaffold modules that recognize phosphoSer/Thr ( p S/ T) containing conserved motifs target and confer conformational changes leading to modulation their functional parameters. Modulation in activity kinases has been attributed interaction with proteins. Herein, we have characterized Plasmodium falciparum its key kinase the parasite,...
The real motivation in the present work is to tune synthesis variables that can result a highly fluorescent and stable DNA copper nanocluster (CuNC) also understand intricate mechanism behind this process. Here, carefully optimized concentrations of various reactants enabled creation DNA-encapsulated CuNC for AT-DNA, displaying size <1.0 nm as confirmed by transmission electron microscopy dynamic light scattering. extremely small AT-DNACuNC supports discrete electronic transitions,...
ABSTRACT Background During the intra-erythrocytic proliferation of Plasmodium falciparum , host erythrocyte invasion is regarded as a complex and tightly regulated process comprising multiple receptor-ligand interactions, numerous secretory molecules. Proteins secreted sequentially from apical organelles merozoites serve adhesins that play crucial role in RBC can vaccine therapeutic targets. Methods Purified were triggered to discharge organelle contents by exposure ionic conditions...
Glutamic acid is an alpha amino that used by almost all living beings. It non–essential acidic acid. MSG (Mono Sodium Glutamate) a food additive. flavour enhancer. traded under the name Aji–no–moto. elicits unique taste known as UMAMI 5th basic different from other tastes(bitter, salty, sour, sweet). generally in treatment of hepatic coma. causes various health hazards. A higher dose Aji–no–moto associated with increased risk obesity. Excessive consumption it promotes cancer growth.