A5060420633- Hepatitis B Virus Studies
- Protein Interaction Studies and Fluorescence Analysis
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Viral gastroenteritis research and epidemiology
- Nanocomposite Films for Food Packaging
- Hepatitis Viruses Studies and Epidemiology
- Advanced Malware Detection Techniques
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Bacillus and Francisella bacterial research
- Advanced Drug Delivery Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Poverty, Education, and Child Welfare
- Protein purification and stability
- Studies on Chitinases and Chitosanases
- Liver Disease Diagnosis and Treatment
- Bacteriophages and microbial interactions
- Adolescent Sexual and Reproductive Health
- DNA and Nucleic Acid Chemistry
- Metal complexes synthesis and properties
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Polydiacetylene-based materials and applications
Jawaharlal Nehru University
2019-2024
Thapar Institute of Engineering & Technology
2024
Guru Gobind Singh Indraprastha University
2020
In biological systems, the unprompted assembly of DNA molecules by cationic ligands into condensed structures is ubiquitous. The ability to provoke packaging crucial molecular organization and functional control DNA, yet their underlined physical roles have remained elusive. Here, we examined condensation mechanism four ligands, including primary DNA-binding modes through extensive biophysical studies. We observed contrasting changes for these binding poly[dGdC]:poly[dGdC] (GC-DNA)...
The insulin-protamine interaction is at the core of mode action in many insulin formulations (Zn + protamine) and to treat diabetes, which protamine added stable form hexameric (Zn-insulin). However, due unavailability quantitative data a high-resolution structure, binding mechanism complex remains unknown. In this study, it was observed that Zn-insulin experiences destabilization as by loss secondary structure circular dichroism (CD), reduction thermal stability melting upon binding....
Introduction: Aluminum salts, although they have been used as adjuvants in many vaccine formulations since 1926, exclusively induce a Th2-biased immune response, thereby limiting their use against intracellular pathogens like Mycobacterium tuberculosis . Methods and Results: Herein, we synthesized amorphous crystalline forms of aluminum hydroxide nanoparticles (AH nps) 150– 200 nm size range. Using Bacillus anthracis protective antigen domain 4 (D4) model antigen, demonstrated that both AH...
Hepatitis E virus (HEV) is an understudied pathogen that causes infection through fecal contaminated drinking water and prominently found in South Asian countries. The affects ~20 million people annually, leading to ~60,000 infections per year. positive-stranded RNA genome of the HEV genotype 1 has four conserved open reading frames (ORFs), which ORF1 encodes a polyprotein 180 kDa size, processed into non-structural enzymes: methyltransferase (MTase), papain-like cysteine protease,...
Purpose: The objective of this research was to generate a tool for the first-line detection fungal infection in plants. Chitin is one unique cell wall polysaccharide which naturally deacetylated chitosan upon infection. It said be involved modulation and plant-pathogen communication. Therefore, could potentially helpful contamination. Methods: Five different phytopathogenic fungi strains were used study. Polyclonal sera raised mice against Trimethylchitosan nanoparticles an enhanced humoral...
The real motivation in the present work is to tune synthesis variables that can result a highly fluorescent and stable DNA copper nanocluster (CuNC) also understand intricate mechanism behind this process. Here, carefully optimized concentrations of various reactants enabled creation DNA-encapsulated CuNC for AT-DNA, displaying size <1.0 nm as confirmed by transmission electron microscopy dynamic light scattering. extremely small AT-DNACuNC supports discrete electronic transitions,...
Fake news detection is an evolving area of research nowadays. This involves quite a lot due to inadequacy available resources. The problem fake causing detrimental effect on society. Because bad societal effects false information, its has attracted increasing attention.We have presented News Detection Tool (FNDT) using various Natural Language Processing and Machine Learning techniques. Our proposed tool based feature selection approaches: Bag Words TF-IDF. We investigated compared the...
There is a successful use of protamine-insulin formulation (Zn+insulin+protamine) to treat diabetes in which protamine added the stable form hexameric insulin (Zn-insulin). The biophysical characterization Zn-insulin, can dissociate biologically active monomers, well reported. However, its interaction with protamine, at core mode action many pharmaceutical formulations, unresolved. Through characterization, we have tried dissect interactions driving Zn-insulin-protamine complexation. Based...