A5067758353- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Inflammasome and immune disorders
- Analysis of environmental and stochastic processes
- Cancer-related gene regulation
- Neonatal Health and Biochemistry
- Autophagy in Disease and Therapy
- Ruminant Nutrition and Digestive Physiology
- Molecular Biology Techniques and Applications
- Autoimmune and Inflammatory Disorders Research
- Cytomegalovirus and herpesvirus research
- Microtubule and mitosis dynamics
- T-cell and B-cell Immunology
- Science, Research, and Medicine
- Macrophage Migration Inhibitory Factor
- Atherosclerosis and Cardiovascular Diseases
Central South University
2015-2024
Second Xiangya Hospital of Central South University
2023
Tongji Hospital
2020
Huazhong University of Science and Technology
2020
Acquired immune responses mediated by CD4+ T cells contribute to the initiation and progression of acute coronary syndrome (ACS). ACS patients show acquired system abnormalities that resemble characteristics autoimmune dysfunction described in elderly. This study aimed investigate role premature senescence underlying mechanism. We compared immunological status 25 patients, 15 young healthy individuals (C1), 20 elderly with absence (C2). The percentages lymphocyte subsets (including naïve,...
Abstract Background: Screening tumor susceptibility genes will be found powerful biomarkers for hereditary cancer monitoring, prevention and diagnosis, which providing opportunities understanding the potential molecular mechanism biomarker precise treatment of syndromes. Methods: Whole blood exon sequencing bioinformatics analysis uncovers a novel RBBP8 (c.841G>T) germline mutation in this familial syndrome, verified by sanger sequencing. Cell proliferation, clone formation, cell...
Abstract Background: Screening tumor susceptibility genes will be found powerful biomarkers for hereditary cancer monitoring, prevention and diagnosis, which providing opportunities understanding the potential molecular mechanism biomarker precise treatment of syndromes. Methods: Whole blood exon sequencing bioinformatics analysis uncovers a novel RBBP8 (c.841G>T) germline mutation in this familial syndrome, verified by sanger sequencing. Cell proliferation, clone formation, cell...
Abstract #2024 Background and Rational: Ethnic-specific disparities in breast cancer (BC) stage of presentation survival rates are well documented. To further investigate possible ethnic-specific genetic contributions to these disparities, we completing gene expression profiling studies a multi-ethnic cohort consisting thirty “Triple Negative” BC patients [10 each African-American (AA), Hispanic (His) non-Hispanic white (Cauc) women] matched for age diagnosis hormone receptor status. The...
Background: Cytarabine (Ara-C) is the first-line drug for treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing efficacy Ara-C in AML patients. The expression SAMHD1, a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, has been reported to be elevated Ara-C-resistant patients and play crucial role mediating AML. mechanism by which SAMHD1 upregulated resistant remains unknown.Methods: Cell culture transfection, cell proliferation assays,...