A5013167915- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Inflammatory Bowel Disease
- Microscopic Colitis
- Salivary Gland Disorders and Functions
- Clostridium difficile and Clostridium perfringens research
- Adolescent and Pediatric Healthcare
Charité - Universitätsmedizin Berlin
2024-2025
German Rheumatism Research Centre
2021-2025
Leibniz Association
2021-2023
IgA-coated fractions of the intestinal microbiota Crohn's disease (CD) patients have been shown to contain taxa that hallmark compositional dysbiosis in CD microbiomes. However, correlation between other cellular properties bacteria and has not explored further, especially for features are directly driven by host immune-system, e.g. expression surface sugars bacteria. By sorting sequencing lectin-stained from healthy controls, we found were distinct bacteria, but still displayed specific...
The commensal microflora provides a repertoire of antigens that illicit mucosal antibodies. In some cases, these antibodies can cross-react with host proteins, inducing autoimmunity, or other microbial antigens. We demonstrate the oral microbiota induce salivary anti-SARS-CoV-2 Spike IgG via molecular mimicry. Anti-Spike in saliva correlated enhanced abundance Streptococcus salivarius 1 month after vaccination. Several human bacteria, including S. salivarius, were recognized by...
ABSTRACT In Brandenburg, Germany, 8% of households rely on single-household cesspits for wastewater collection. This study analysed the chemical and microbial characteristcs wastewaters from 12 pit lorry samples to assess their suitability water reuse. The analyses include physico-chemical parameters (pH, electrical conductivity, biochemical oxygen demand, total nitrogen, ammonium, phosphorus), 11 heavy metals, 67 organic trace substances, bacteria concentrations. Measurements showed strong...
Juvenile Idiopathic Arthritis (JIA) comprises diverse chronic inflammatory conditions driven by malfunction of the immune system. The intestinal microbiota is considered a crucial environmental factor correlating with diseases, and for JIA certain alterations in have already been described.
Abstract The commensal microflora is a source for multiple antigens that may induce cross-reactive antibodies against host proteins and pathogens. However, whether bacteria can SARS-CoV-2 remains unknown. Here we report several contribute to the generation of IgA receptor-binding domain (RBD) Spike protein. We identified unexposed individuals with RBD-binding at their mucosal surfaces. Conversely, neutralising monoclonal anti-RBD recognised distinct bacterial species. Some these bacteria,...