Changxian Yi

ORCID: 0000-0003-3504-7274
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About
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Research Areas
  • Ocular Diseases and Behçet’s Syndrome
  • Retinal and Optic Conditions
  • Retinal Diseases and Treatments
  • Drug-Induced Ocular Toxicity
  • Retinal Imaging and Analysis
  • Receptor Mechanisms and Signaling
  • Retinal and Macular Surgery
  • Regulation of Appetite and Obesity
  • Traumatic Ocular and Foreign Body Injuries
  • Retinal Development and Disorders
  • Intraocular Surgery and Lenses
  • Chaos control and synchronization
  • Antioxidant Activity and Oxidative Stress
  • Hemoglobinopathies and Related Disorders
  • Facial Trauma and Fracture Management
  • Nonlinear Photonic Systems
  • Syphilis Diagnosis and Treatment
  • Cellular transport and secretion
  • Genomic variations and chromosomal abnormalities
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Ocular and Laser Science Research
  • Cerebral Venous Sinus Thrombosis
  • Biochemical Analysis and Sensing Techniques
  • Corneal Surgery and Treatments
  • Glaucoma and retinal disorders

Sun Yat-sen University
2003-2016

Qilu Hospital of Shandong University
2016

Zhongshan Ophthalmic Center, Sun Yat-sen University
2001-2011

National Yang Ming Chiao Tung University
2006

Age-related macular degeneration (AMD) is the leading cause of severe visual loss in aged people. Melatonin has been shown to have capacity control eye pigmentation and thereby regulate amount light reaching photoreceptors, scavenge hydroxyradicals protect retinal pigment epithelium (RPE) cells from oxidative damage. Therefore, it reasonable think that physiological decrease melatonin people may be an important factor RPE dysfunction, which a well known for initiation AMD. Our purpose...

10.1196/annals.1356.029 article EN Annals of the New York Academy of Sciences 2005-12-01

Reports of terminal and interstitial deletions the long arm chromosome 2 are rare in literature.Here, we present a case report concerning Chinese boy with 47,XYY karyotype de novo deletion comprising approximately 5 Mb between 2q35 q36.1, along syndactyly, type III Waardenburg syndrome, congenital heart disease.High-resolution analysis D. Wang et al. Genetics Molecular Research 15 (4): gmr15049060to detect copy number variations was carried out using an Affymetrix microarray platform, genes...

10.4238/gmr15049060 article EN Genetics and Molecular Research 2016-01-01

To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma (JOAG) caused by Pro370Leu myocilin (MYOC) mutation.Fifteen members three-generation JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected have got an assessment visual field optical coherence tomography. Intraocular pressures (IOPs) four patients measured at 8, 10, 12, 14, 17 o'clock respectively after using drugs....

10.3980/j.issn.2222-3959.2014.01.08 article EN DOAJ (DOAJ: Directory of Open Access Journals) 2014-01-01

Click to increase image sizeClick decrease sizeKey Words: agingepiphysismelatoninthyrotropin releasing hormone

10.3109/00207459008999737 article EN International Journal of Neuroscience 1990-01-01

From the Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Science, Guangzhou, China. Reprint requests: Changxian Yi, MD, 510060 PR China; e-mail: [email protected] The authors have no proprietary interest in contents this article.

10.1097/00006982-200110000-00017 article EN Retina 2001-10-01

X-linked juvenile retinoschisis (XLRS) is a major cause of macular degeneration in young men. In this study we analyzed all six exons the XLRS1 gene four sporadic XLRS patients and an affected family China who were recently diagnosed. We found there are five different mutations with containing missense point one having frame-shift deletion. Among these both c.644A > T c.520delC novel have not been previously reported. Moreover second-generation offsprings most third-generation ones to carry...

10.1080/02713680701486410 article EN Current Eye Research 2007-01-01

Uveal effusion syndrome is a rare disease characterized by exudative detachments of the choroid, ciliary body, and retina. Various surgical procedures nonsurgical strategies have been described to treat uveal with limited success. The treatment for remains serious challenge clinicians. To best our knowledge, no previous report has severe patient nanophthalmos treated using an anti-vascular endothelial growth factor agent alone. We here one such case unexpected positive results.A 30-year-old...

10.1186/s13256-021-03101-z article EN cc-by Journal of Medical Case Reports 2021-10-18

With the increasingly extensive application of erectile dysfunction (ED) drugs , it is importance for an ophthalmologist to understand association between these and human eyes. In this study, we retrospectively studied effects ED on eyes, including visual symptoms, ophthalmological electrophysiology, ocular blood flow, intraocular pressure, field, retina, cerebral hemodynamics nervous system retinal vessels, particularly focusing relationship agents nonarteritic ischemic optic neuropathy...

10.3969/j.issn.1000-4432.2011.02.024 article EN Yanke xuebao 2011-06-01

Objective To investigate the impact of detachment and edema acute macular retinal nerve fiber layer on visual prognosis in patients with Vogt-Koyanagi-Harada syndrome(VKHs).Methods A retrospective analysis was performed lesions,visual distribution before after treatment 74 VKHs first attack (108 eyes) whom visited Zhongshan Ophthalmic Center,Sun Yat-sen University from December 2006 to January 2009.The post-treatment vision or without were compared.Results There 53 (71.62%),and 21 (28.38%)...

10.3760/cma.j.issn.1674-1927.2014.01.014 article EN Chin J Biomed Eng 2014-02-15

Objective To evaluate the efficacy and security of therapeutic scheme to patients Vogt-Koyanagi-Harada syndrome.Methods A retrospective analysis was given 108 with syndrome dated from Dec.2006 Jan.2009 on recurrence,medication,visual prognosis course treatment.The visual recurrence first-visit cases transfer-visit were compared.Results Cyclosporin applied in 49.07% patients.38.27% 81.48% first attack recurrent respectively; ≥1.0 better than (P <0.05); rate (5.41%) lower (17.65%)...

10.3760/cma.j.issn.1006-4443.2014.02.011 article EN Chinese Journal of Practical Ophthalmology 2014-02-10

Objective To analyze the causes of misdiagnosis acute retinal necrosis syndrome (ARN),and possible critical points in preventing misdiagnosis.Methods Clinical data 81 cases (93 eyes) in-patients with ARN from May 2006 to 2012 Zhongshan Ophthalmic Center,Sun Yat-sen University were retrospectively analyzed.Results The average time first visit after appearance ocular symptoms was 7.03 days (1 21 days),86 eyes (91.36%) misdiagnosed total.There only 7 that correctly diagnosed at initial...

10.3760/cma.j.issn.1006-4443.2013.12.039 article EN Chinese Journal of Practical Ophthalmology 2013-12-10

Objective To determine the effect of total vitrectomy treating acute retinal necrosis syn-drome (ARNS).Methods A consecutive 17 eyes human immunodeficiency virus-negative patients with ARNS were surgeried technique between March 2003 and October 2006.There reti-nal detachment (RD)in 13 no RD in 4 eyes.The surgical techniques included vitrectomy, mere-bran-peeling epiretinal membranes necrosing retina relaxing retinotomies/retinectomies,injecting per-flurocarbon liquid, endolaser...

10.3760/cma.j.issn.1006-4443.2009.01.033 article EN Chinese Journal of Practical Ophthalmology 2009-01-10
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