A5052674811- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Infant Development and Preterm Care
- SARS-CoV-2 and COVID-19 Research
- Immune responses and vaccinations
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Ion channel regulation and function
- Advanced Chemical Sensor Technologies
- Facial Nerve Paralysis Treatment and Research
- Delphi Technique in Research
- Immunodeficiency and Autoimmune Disorders
- Blood groups and transfusion
- Adrenal Hormones and Disorders
- Complement system in diseases
- Neonatal and Maternal Infections
- Dermatological and COVID-19 studies
- Vaccine Coverage and Hesitancy
- Breastfeeding Practices and Influences
- Stress Responses and Cortisol
University of Amsterdam
2008-2025
Amsterdam University Medical Centers
2020-2025
Emma Kinderziekenhuis
2020-2025
Vrije Universiteit Amsterdam
2021-2024
Academic Center for Dentistry Amsterdam
2008
Amsterdam UMC Location University of Amsterdam
2008
Background: Since the outbreak of coronavirus disease 2019 (COVID-19), many put their hopes in rapid availability effective immunizations. Human milk, containing antibodies against syndrome 2 (SARS-CoV-2), may serve as means protection through passive immunization. We aimed to determine presence and pseudovirus neutralization capacity SARS-CoV-2 specific IgA human milk mothers who recovered from COVID-19, effect pasteurization on these antibodies. Methods: This prospective case control study...
It has been demonstrated that human milk from mothers who have infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains antibodies against the virus, which could play an important role in protecting recipient infant disease 2019 (COVID-19). Seroconversion is measured frequently around world, but conversion rate unknown.To determine (1) prevalence and (2) dynamics of immunoglobulin A (IgA) SARS-CoV-2 amongst lactating Netherlands.In this large prospective cohort...
Abstract The most abundant immunoglobulin present in the human body is IgA. It has highest concentrations at mucosal lining and biofluids such as milk second class of antibodies serum. We assessed structural diversity clonal repertoire IgA1-containing molecular assemblies longitudinally serum from three donors using a mass spectrometry-based approach. IgA-containing molecules purified or were by release subsequent analysis their Fab fragments. Our data revealed that IgA1 consists two...
Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) following Disease 2019 (COVID-19). These may serve as protection COVID-19 in infants. However, the evolution of these human over time is unclear.To elucidate immunoglobulin A (IgA) SARS-CoV-2 after a infection.This longitudinal follow-up study included lactating mothers (N = 24) who had participated COVID MILK study. To assess antibodies, serum and samples were collected 14-143 days onset...
Human milk is important for antimicrobial defense in infants and has well demonstrated antiviral activity. We evaluated the protective ability of human against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection a fetal intestinal cell culture model. found that, this model, blocks SARS-CoV-2 replication, irrespective presence spike-specific antibodies. Complete inhibition both enveloped Middle East syncytial virus infections was also observed, whereas no non-enveloped...
Machine learning models predicting neurodevelopmental outcome in preterm infants have great potential, but often relied on inaccessible brain magnetic resonance imaging measurements. This study aimed to build using readily available clinical predictors and investigate the potential of vital sign data prediction after birth. Readily from antenatal neonatal period born <30 weeks gestation were combined with first seven days birth predict motor cognitive at two five years corrected age. A...
Abstract Background Since the outbreak of COVID-19, many put their hopes in rapid development effective immunizations. For now patient isolation, physical distancing and good hygiene are sole measures for prevention. Processed breast milk with antibodies against SaRS-CoV-2 may serve as additional protection. We aimed to determine presence neutralization capacity breastmilk mothers who have recovered from COVID-19. Methods This prospective case control study included lactating mothers,...
Background: Chronic stress is often accompanied by alterations in the diurnal rhythm of hypothalamus–pituitary–adrenal activity. However, there are limited data on rhythmicity breast milk glucocorticoids (GCs) among women with psychological distress. We compared mothers who sought consultation at an expertise center for pregnant increased risk distress control GC and saliva obtained same time. Methods: included 19 psychiatry–obstetric–pediatric (POP) outpatient clinic 44 mothers. One month...
Abstract Studies in preterm infants have shown an association between late-onset sepsis (LOS) and the development of bronchopulmonary dysplasia (BPD). It is unknown whether clinical or biochemical characteristics during modulate risk for BPD. This single-center retrospective cohort study included all patients with a gestational age < 30 weeks, born 2009 2015, whom empiric antimicrobial treatment was initiated > 72 h after birth continued at least 5 days, independent on microbiological...
Since the outbreak of coronavirus disease 2019 (COVID-19), many put their hopes in rapid development effective immunizations. As this intervention will not be available on a short notice, patient isolation, physical distancing, protective materials and good hygiene are currently sole measures for prevention. Here we provide multiple lines evidence presence variety antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) present breastmilk from mothers who have recovered COVID-19,...
Sex-specific differences in hypothalamic-pituitary-adrenal axis activity might explain why male preterm infants are at higher risk of neonatal mortality and morbidity than their female counterparts. We examined whether differed cortisol production metabolism 10 days post-partum.This prospective study included 36 born (18 boys) with a very low birth weight (VLBW) (<1.500 g). At postnatal age, urine was collected over 4- to 6-h period. Glucocorticoid metabolites were measured using gas...
Abstract Background Preterm infants, especially those born small for gestational age (SGA), are at risk of short-term and long-term health complications. Characterization changes in circulating proteins postnatally preterm infants may provide valuable fundamental insights into this population. Here, we investigated postnatal developmental patterns explored protein signatures that deviate between SGA appropriate (AGA) using a mass spectrometry (MS)-based proteomics workflow. Methods...
Thyroid storm is a well-known complication of surgical procedures in the lower neck, but rare after blunt neck trauma. The cases described previously have mainly focussed on adults with pre-existent thyroid disease. In this case report, we describe disease course healthy adolescent who had asymptomatic hyperthyroxinemia trauma jaw and neck. Case Presentation. A 17-year-old girl presented at our emergency department she fell her head while roller blading. On physical examination, among other...
Abstract The most abundant immunoglobulin present in the human body is IgA1. It has highest concentrations at mucosal lining and biofluids such as milk second class of antibodies serum. We assessed structural diversity clonal repertoire IgA1-containing molecular assemblies longitudinally serum from three donors using a mass spectrometry-based approach. IgA-containing molecules purified or were by release subsequent analysis their Fab fragments. Our data revealed that IgA1 consists two...