A5005831187- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Acute Myeloid Leukemia Research
- interferon and immune responses
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Glaucoma and retinal disorders
- Bioinformatics and Genomic Networks
- Retinal Imaging and Analysis
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Congenital Heart Disease Studies
- Genomics and Phylogenetic Studies
- Heart Rate Variability and Autonomic Control
- Cervical Cancer and HPV Research
- Cardiovascular Function and Risk Factors
- Mosquito-borne diseases and control
- Asthma and respiratory diseases
- Gene expression and cancer classification
Minneapolis Heart Institute Foundation
2023-2025
The University of Texas MD Anderson Cancer Center
2021-2025
MSB Medical School Berlin
2024
Children's Mercy Hospital
2019-2021
Stanford University
2017-2019
Stanford Medicine
2019
Universität Hamburg
1995-2018
University Medical Center Hamburg-Eppendorf
1995-2018
University of California, San Francisco
2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2016
For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) CTLA4 inhibitors and PD-1 or PD-L1 (hereafter, PD-(L)1 inhibitors) is associated higher rates of anti-tumour activity immune-related toxicities, when compared treatment alone. However, there are currently no validated biomarkers to identify which will benefit from ICB1,2. Here we show that NSCLC who have mutations in the STK11 and/or KEAP1 tumour suppressor genes derived clinical ICB...
Lineage tracing by the determination and mapping of progeny arising from single cells is an important approach enabling elucidation mechanisms underlying diverse biological processes ranging development to disease. We developed a dynamic sequence-based barcode system for synthetic lineage have demonstrated its performance in C. elegans, model organism whose tree well established. The strategy we use creates trees based upon introduction synthetically controlled mutations into propagation...
Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations allergic diseases. Neurotrophin levels are up-regulated endobronchially after allergen challenge. This coincides with an influx of activated eosinophils into the bronchial lumen. These increased viability CD69 expression 18 h segmental provocation (SAP) which is not present peripheral blood. To investigate whether these observations related...
Non-small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are immunologically warm tumors with partial responsiveness to anti-PD-(L)1 blockade; however, most patients observe little or no durable clinical benefit. To identify novel tumor-driven resistance mechanisms, we developed a panel of KP murine cancer models intrinsic anti-PD-1 queried differential gene expression between these anti-PD-1-sensitive tumors. We found the enzyme autotaxin (ATX), metabolite it...
Patients with diabetes mellitus are at increased risk for microvascular complications. Early changes in microcirculation characterized by hyperperfusion (e.g. the retina and kidney) pulse wave reflection leading to aortic pressure. We investigated effects of DPP-4-inhibitor saxagliptin on early retinal changes. In this double-blind, controlled, cross-over trial 50 patients (without clinical signs alterations) type-2 (mean duration 4 years) were randomized receive placebo or 5 mg 6 weeks....
Abstract Purpose: Ataxia-telangiectasia mutated (ATM) is the most frequently DNA damage repair gene in non–small cell lung cancer (NSCLC). However, molecular correlates of ATM mutations and their clinical implications have not been fully elucidated. Experimental Design: Clinicopathologic genomic data from 26,587 patients with NSCLC MD Anderson, public databases, a de-identified nationwide (US-based) clinicogenomic database (CGDB) were used to assess co-mutation landscape, protein expression,...
Summary Background The interaction of chemokines with their receptors strongly influences the migration leucocytes. Objective In order to assess contribution these molecules local recruitment T cells in bronchial asthma, we analysed expression 14 chemokine on lung‐derived cells. Methods Chemokine‐receptor by derived from peripheral blood, bronchoalveolar lavage fluid and mucosa was flow cytometry immunohistochemistry. Expression profiles healthy mildly asthmatic individuals were compared,...
The long-term relationship between 24-hour ambulatory blood pressure (ABP) and office BP in patients on therapy is not well documented. From a registry we included all whom antihypertensive needed to be uptitrated. Drug treatment the direct renin inhibitor aliskiren or an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker drugs blocking renin-angiotensin system, alone top of existing drug regimen. In patients, ABP were obtained at baseline after 1 year with validated...
Abstract Despite advances in understanding and treating Prostate Cancer (PCa), there has been little effort to systematically map the biology distinguishing Early-(EOPCa) Late-(LOPCa) onset PCa. Around 25% of EOPCa cases present with metastatic spread or aggressive disease earlier development. Some available lines therapy are extending treatment trajectories prolonging lives. However, remains a critical clinical need identify new therapeutic targets for where life expectancy necessitates...
In patients with diabetic maculopathy, evaluation of visual acuity alone may not represent central retinal function sufficiently. Despite good acuity, suffer from disturbances like waviness, relative scotoma, loss fixation and decrease contrast sensitivity. The aim the study was to assess localized light sensitivity in field determine stability maculopathy moderate comparison healthy controls.Twenty-seven (mean age: 54 +/- 15; range 17-81 years) 61 controls 45 22; 18-85 were included study....
Asthma has been linked to a chronic, T-cell-mediated bronchial inflammation. Because other T-lymphocyte-mediated, chronic inflammatory disorders have associated with elevated granzyme B (grB) expression we tested the hypothesis that atopic asthma might be grB levels in bronchoalveolar compartment. Therefore performed intracellular staining lymphocytes from lavage (BAL) collected 42 h after segmental allergen provocation (SAP) allergic patients asthma. There was significant increase CD3(+),...
Renal denervation (DNX) is a treatment for resistant arterial hypertension. Efferent sympathetic nerves regrow, but reinnervation by renal afferent has only recently been shown in the pelvis of rats after unilateral DNX. We examined intrarenal perivascular and efferent surgical Tyrosine hydroxylase (TH), CGRP, smooth muscle actin were identified kidney sections from 12 Sprague-Dawley rats, to distinguish afferents, efferents, vasculature. DNX kidneys nondenervated 1, 4, wk Tissue levels CGRP...
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 (Cas9) systems have been effectively harnessed to engineer the genomes of organisms from across tree life. Nearly all currently characterized Cas9 proteins are derived mesophilic bacteria, and canonical challenged by applications requiring enhanced stability or elevated temperatures. We discovered IgnaviCas9, a protein hyperthermophilic Ignavibacterium identified through mini-metagenomic sequencing samples hot...
Experimental studies have shown that glucose releases endothelial nitric oxide (NO) and NO contributes to renal hyperperfusion in models of diabetes. To examine whether this translates into the human condition, we studied relationship between glycemic control activity patients with type 2 diabetes.A total 113 diabetes a wide range HbA1c concentrations were included. Renal plasma flow (RPF) glomerular filtration rate (GFR) determined by constant infusion input clearance. Functional...
In hypertension, changes in small arterial structure are characterized by an increased wall-to-lumen ratio (WLR). These adaptive processes modulated the rennin-angiotensin system. It is unclear whether direct renin inhibitors exert protective effects on arteries hypertensive patients.In this double-blind, randomized, placebo-controlled study (http://www.clinicaltrials.gov: NCT01318395), 114 patients with primary hypertension were randomized to additional therapy either placebo or aliskiren...
<title>Abstract</title> Integrative multi-omics analysis provides deeper insight and enables better more realistic modeling of the underlying biology causes diseases than does single omics analysis. Although several integrative methods have been proposed demonstrated promising results in integrating distinct datasets, inconsistent distribution different data, which is caused by technology variations, poses a challenge for paired methods. In addition, existing discriminant analysis–based do...