A5103124637- Antibiotic Resistance in Bacteria
- Cancer therapeutics and mechanisms
- Reproductive tract infections research
- Hereditary Neurological Disorders
- T-cell and Retrovirus Studies
- Antibiotics Pharmacokinetics and Efficacy
- Urinary Tract Infections Management
- Animal Disease Management and Epidemiology
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Vector-Borne Animal Diseases
- Bacterial Infections and Vaccines
- Enterobacteriaceae and Cronobacter Research
- Aquaculture disease management and microbiota
- Infectious Disease Case Reports and Treatments
- Neutropenia and Cancer Infections
- Nuclear Structure and Function
- Biological Research and Disease Studies
- ECG Monitoring and Analysis
- Bioactive Compounds and Antitumor Agents
- Bladder and Urothelial Cancer Treatments
- Parasitic Infections and Diagnostics
- Pediatric Urology and Nephrology Studies
- Amyotrophic Lateral Sclerosis Research
- Agriculture and Farm Safety
University of the Ryukyus
2013-2024
Kagoshima University
2016-2020
National Hospital Organization
2016-2017
Memorial Hospital of South Bend
2010
Gifu University
1997-2000
Kyorin University
2000
Of 150 clinical isolates of Neisseria gonorrhoeae recovered in 2001, we examined 55 N. for which cefixime MICs were > or=0.125 microg/ml and randomly selected 15 < or =0.06 analysis alterations the penicillin-binding protein 2 (PBP 2) gene. We found insertion an extra codon (Asp-345a) transpeptidase domain PBP 2, this occurred alone conjunction with other amino acid substitutions. also a mosaic that was composed fragments proteins from cinera perflava. This significantly associated decreased...
Objective The objective of this study was to identify new causes Charcot–Marie–Tooth (CMT) disease in patients with autosomal‐recessive (AR) CMT. Methods To efficiently novel causative genes for AR‐CMT, we analyzed 303 unrelated Japanese CMT using whole‐exome sequencing and extracted recessive variants/genes shared among multiple patients. We performed mutation screening the newly identified membrane metalloendopeptidase ( MME ) gene 354 additional clinically, genetically, pathologically,...
We determined a partial sequence of the Klebsiella pneumoniae parC gene, including region analogous to quinolone resistance-determining Escherichia coli gyrA and examined 26 clinical strains K. for an association alterations in GyrA ParC with susceptibilities quinolones. The study suggests that DNA gyrase is primary target quinolones play complementary role development higher-level fluoroquinolone resistance.
Abstract Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neurodegenerative disease. This multicenter, randomized phase 3 study evaluated the efficacy and safety of 0.3 mg/kg intravenous mogamulizumab, monoclonal antibody targeting-CC chemokine receptor 4, every 12 weeks in HAM/TSP patients. comprised 24-week double-blind, placebo-controlled period, open-label extension treatment period. The primary endpoint was proportion...
Several genes related to mitochondrial functions have been identified as causative of neuropathy or ataxia. Cytochrome c oxidase assembly factor 7 (COA7) may a role in assembling respiratory chain complexes that function oxidative phosphorylation. Here we four unrelated patients with recessive mutations COA7 among Japanese case series 1396 Charcot-Marie-Tooth disease (CMT) other inherited peripheral neuropathies, including complex forms CMT. We also found all had characteristic neurological...
Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized trials. This controlled trial included 8 and 30 HAM patients with rapidly slowly progressing walking disabilities, respectively. Rapid progressors were assigned (1:1) receive or a 3-day course of intravenous methylprednisolone addition oral prednisolone therapy. Meanwhile, slow placebo. The primary outcomes composite ≥1-grade improvement the...
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder that causes motor symptoms and autonomic dysfunction. However, function tests commonly performed in PD can only evaluate either the sympathetic or parasympathetic nervous system. Therefore, purpose of this pilot study to investigate whether power spectral analysis heart rate variability could detect both dysfunctions patients with PD. Methods Seventeen 11 healthy control subjects underwent...
Mutations in small heat shock protein beta-1 (HspB1) have been linked to Charcot-Marie-Tooth (CMT) disease type 2F and distal hereditary motor neuropathy 2B. Only four cases with HSPB1 mutations reported date Japan. In this study between April 2007 October 2014, we conducted gene panel sequencing a case series of 1,030 patients inherited peripheral neuropathies (IPNs) using DNA microarray, targeted resequencing, whole-exome sequencing. We identified variants 1.3% (13 1,030) the IPNs, who...
ABSTRACT We examined 22 clinical isolates of Staphylococcus epidermidis to analyze the association alterations in GyrA and ParC with fluoroquinolone resistance. The simultaneous presence was associated a high level resistance S. .
Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) gene have been reported with different clinical phenotypes including Silver syndrome (SS)/spastic paraplegia 17 (SPG17), distal hereditary motor neuropathy type V (dHMN-V), and Charcot-Marie-Tooth (CMT) disease 2. We screened 407 Japanese patients who were clinically suspected of having CMT by exome sequencing searched BSCL2. As a result, we identified five heterozygous confirmed three cases known (p.N88S...
OX40 is a member of the tumor necrosis factor receptor family that expressed primarily on activated CD4+ T cells and promotes development effector memory cells. Although has been reported to be target gene human T-cell leukemia virus type-1 (HTLV-1) viral transactivator Tax overexpressed in vivo adult (ATL) cells, an association between HTLV-1-associated inflammatory disorders, such as myelopathy/tropical spastic paraparesis (HAM/TSP), not yet established. Moreover, because abrogation...
The in-vitro antimicrobial activity of DU-6859a, a new fluoroquinolone, was tested against 55 clinical isolates Neisseria gonorrhoeae. MIC DU-6859a inhibiting 90% (MIC90) the with genetic alterations both GyrA subunit DNA gyrase and ParC topoisomerase IV 0.125 mg/L. MIC90 for alone or without 0.03 mg/L 0.004 mg/L, respectively. potency bearing associated quinolone resistance significantly greater than that currently available fluoroquinolones.
Urinary dysfunction is one of the main features human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, a comprehensive assessment severity difficult because standardized measure unavailable. Therefore, this study aimed to develop novel symptom score for urinary in HAM/TSP. We interviewed 449 patients with HAM/TSP using four internationally validated questionnaires symptoms (27 question items total): International Prostate Symptom Score;...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2000IN VITRO SELECTION OF FLUOROQUINOLONE-RESISTANT NEISSERIA GONORRHOEAE HARBORING ALTERATIONS IN DNA GYRASE AND TOPOISOMERASE IV MITSURU YASUDA, HIDEYUKI FUKUDA, SHIGEAKI YOKOI, SATOSHI ISHIHARA, YUKIMICHI KAWADA, and TAKASHI DEGUCHI YASUDAMITSURU YASUDA More articles by this author , FUKUDAHIDEYUKI FUKUDA YOKOISHIGEAKI YOKOI ISHIHARASATOSHI ISHIHARA KAWADAYUKIMICHI KAWADA DEGUCHITAKASHI View All Author...
A 65-year-old man was referred to our hospital with dyspnoea due acute heart failure. He presented swelling in the left clavicle and pustulosis on both soles. An antihypertensive drug non-invasive positive pressure ventilation improved his condition rapidly. Since all physical symptoms were compatible criteria of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteomyelitis) syndrome, we suspected that syndrome might cause The aetiology between failure is unclear. Further studies are...
Acute progressive weakness in bulbar, neck and limbs is included several differential diagnoses, including the pharyngeal-cervical-brachial (PCB) variant of Guillain-Barré syndrome (GBS). Patients with PCB GBS are reported to have localized diagnostic cervical spinal nerve abnormalities that can be examined by ultrasonography (NUS) magnetic resonance neurography (MRN). We herein report case a 77-year-old man GBS. Although conduction study (NCS) findings were indirect indicators for an early...
舌における針筋電図検査（electromyography; EMG）と超音波検査（ultrasonography; US）を施行した当科入院連続20例の筋萎縮性側索硬化症（amyotrophic lateral sclerosis; ALS）において，両検査結果と臨床症状を後ろ向きに検討した．EMG・US・視診にてfasciculationあるいはfibrillation potentials/positive sharp waveの異常が検出されたのは，それぞれEMG 12例，US 6例，視診9例であった．EMGがUSより先行して異常所見を捉えたのは12例中7例，USがEMGより先行して異常所見を捉えたのは1例であった．以上よりEMGをUSで代替することは，少なくとも当院の現在の方法論においては困難であり，併用が有用であると考えられた．
We attempted to select increasingly fluoroquinolone-resistant strains of Neisseria gonorrhoeae in vitro and assess whether selected mutants harbored alterations the GyrA subunit DNA gyrase ParC topoisomerase IV, which were analogous those clinical isolates.A fluoroquinolone-susceptible strain was exposed norfloxacin vitro. Selected sequentially norfloxacin, this procedure repeated. For 11 mutants, minimum inhibitory concentrations (MICs) antimicrobial agents determined, mutations region...
Paroxysmal kinesigenic choreoathetosis (PKC) is a rare disorder characterized by recurrent and brief attacks of choreoathetoid and/or dystonic movements in trunk limbs triggered initiation voluntary movement. Of 5 patients with idiopathic PKC our hospital, four were men one was family history. Age onset ranged from 8 to 15 years old. They consistent previous reports the characteristics involuntary movements, normal neurological findings, laboratory data, no abnormal findings standard imaging...