A5043968617- Medicinal Plant Pharmacodynamics Research
- Flavonoids in Medical Research
- Traditional Chinese Medicine Analysis
- Advanced Drug Delivery Systems
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Botanical Studies and Applications
- Pharmacological Effects of Natural Compounds
- Nanoparticle-Based Drug Delivery
- Natural Compounds in Disease Treatment
- Drug Solubulity and Delivery Systems
- Plant-based Medicinal Research
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Synthesis and bioactivity of alkaloids
- Beetle Biology and Toxicology Studies
- Biological Stains and Phytochemicals
- Saffron Plant Research Studies
- Phytochemical and Pharmacological Studies
- Cancer Research and Treatments
- Phytochemistry and biological activity of medicinal plants
- Anesthesia and Neurotoxicity Research
- Synthesis of Organic Compounds
- Airway Management and Intubation Techniques
Zhejiang Chinese Medical University
2012-2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2025
Shaanxi University of Chinese Medicine
2025
Ningxia Medical University
2025
Tongren Hospital
2022
Shanghai Jiao Tong University
2022
Sun Yat-sen University
2020
Fifth Affiliated Hospital of Sun Yat-sen University
2020
Hangzhou Xixi hospital
2014
Hangzhou Cancer Hospital
2013
Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with fast metastasis and high mortality rate. GC cells tumor immune microenvironment exhibit heterogeneity. Multiple pieces evidence suggest that TGFβ1 intervenes in microenvironment, prognosis. The aim this study to comprehensively investigate functional intervention macrophage polarization subtypes on gastric cell lines providing valuable insights into research potential targets for treatment strategies....
To investigate the acute toxicity of Sanghuangporus ethanol extract (SHEE) on ICR mice and underlying mechanism anti-hyperuricemic renal injury. were given a single gavage 1250, 2500, 5000 mg/kg SHEE, general behavior, mortality, body weight, dietary, water intake evaluated within 14 days to determine level. The hyperuricemic kidney injury model in was induced with potassium oxonate (PO) adenine, subsequently treated SHEE (125, 250, 500 mg/kg). HE hexamine silver staining (PASM) used observe...
Two way effects of Tween 80 and soybean lecithin (PL) on the stability cyclodextrin (CD) Pickering emulsions.
As a biopharmaceutics classification system (BCS) class IV drug, breviscapine (Bre) has low solubility in water, poor chemical stability, short biological half-life and rapid removal from plasma. This paper prepared Bre nanosuspension (Bre-NS) by an ultrasound-assisted anti-solvent precipitation method. Characterization of Bre-NS was studied using Box-Behnken design concerning drug concentration DMSO, anti-solvent-to-solvent ratio, sonication time. Under the optimized conditions 170 mg/mL...
The aim of this study was to investigate the protective effect Free and Easy Wanderer (FAEW) on avoidance behavior induced by feeding Heat-Killed Escherichia coli, elucidate underlying mechanisms. Initially, effects FAEW behavior, survival, neuroendocrine signaling gene expression, intestinal bloating were examined. impact gut-germline-neural assessed monitoring H4K8ac expression par-5 RNAi animals glp-1(e2141) mutants. RNA-sequencing conducted analyze potential pathways. Finally, examined...
Introduction There are about 2,300,000 new cases of breast cancer worldwide each year. Breast has become the first most common in world and leading cause death among women. At same time, chemotherapy resistance patients with advanced is still a serious challenge. Alpinia Katsumadai Hayata (AKH), as traditional Chinese herbal medicine, wide range pharmacological activities. Related studies have found that many compounds AKH anti-breast activity. However, it worth exploring which component...
Melanoma is one of the most common malignant tumors. The anti-PD-1 antibody used for treatment metastatic melanoma. Treatment success only 35–40% and a range immune-related adverse reactions can occur. Combination anti-PD1 therapy with other oncology therapies has been attempted. Herein, we assessed whether chlorogenic acid liposomes modified sialic (CA-SAL) combined was efficacious as immunotherapy CA-SAL were prepared characterized. In mouse model B16F10 tumor, mice treated an antibody,...
Objective: To study the extraction process of agarwood active ingredients (AA) and investigate safety effectiveness AA in treatment insomnia rats by nasal administration. Method: A β-cyclodextrin (β-CD) inclusion compound (a-β-CD) was prepared from essential oil (AEO), preparation optimized characterized. The mucosa evaluated through Bufo gargarizans maxillary rat models. Insomnia animal models were replicated injecting p-chlorophenylalanine (PCPA), conducting behavioral tests, detecting...
This research aimed to develop and evaluate a novel multi-ethosome (ME) system for the dermal delivery of terbinafine hydrochloride (TH) as new approach fungal infection treatment. TH-loaded MEs were successfully prepared using cinnamaldehyde penetration enhancer. Mean diameter ME was found ~100 nm with monodispersed size distribution. Drug entrapment efficiency reached up 86% ± 1.4%. exhibited excellent colloid stability no drug leakage after 2 months storage. In contrast commercial...
As a clinical empirical prescription for ophthalmology, compound chrysanthemum has been used gradually and good effect on eye fatigue. However, the detailed mechanisms of antiasthenopia have not studied. In order to clarify in treatment asthenopia, network pharmacology was combined with experimental study this paper. A total 593 genes 39 active chemicals were identified, both considered be essential advancement asthenopia research. The results molecular docking analysis demonstrated certain...
To study rhein's permeative properties of acupoint and non-acupoint different species' transdermal administration in vitro. Cumulative permeation amount steady-state infiltration rate were taken as evaluative indexes to assess the permeability difference. The Valia-Chien diffusion cell method was used conduct test, with fresh skin rat, rabbit swine vitro barriers, blank 20% EtOH saline absorption liquid. HPLC determine rhein. difference observed by confocal laser scanning microscopy. 24-hour...
Tripterygium wilfordii Hook. f. (TW) is a traditional herbal medicine which has been widely used for the treatment of rheumatoid arthritis and other autoimmune diseases. However, adverse reactions TW such as hepatotoxicity nephrotoxicity have frequently reported in clinic. With aim to evaluate potency toxicity TW, we collected eleven batches from different localities across Chinese mainland, investigated inhibition their methanol extracts on proliferation mouse spleen lymphocytes, normal...
The objective of this study was to examine the preparation process DSPE-PEG-C60/NCTD micelles and assess impact fullerenol (C60)-modified on nephrotoxicity antitumor activity NCTD.The containing NCTD were prepared using ultrasonic method subsequently optimized characterized. cytotoxicity loaded with assessed CCK-8 human hepatoma cell lines HepG2 BEL-7402, as well normal HK-2 L02. Acridine orange/ethidium bromide (AO/EB) double staining flow cytometry employed NCTD-loaded apoptosis cells...
Abstract Currently, Akebiae Caulis is being used in clinical practice, but there are few reseaches on its different varieties. To ensure the accuracy and effectiveness of this study distinguished Akebia quinata (Thunb.) Decne. trifoliata Koidz, using organoleptic evaluation, microscopic observation, fluorescence reaction, physicochemical properties, thin‐layer chromatography, IR spectroscopy, HPLC, four machine learning models, vitro antioxidant methods. Analysis powders these two varieties...