A5025784529- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- COVID-19 Clinical Research Studies
- Infectious Diseases and Tuberculosis
- Emergency and Acute Care Studies
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Family and Patient Care in Intensive Care Units
- Child and Adolescent Health
37 Military Hospital
2016-2024
Mycobacterium africanum comprises two phylogenetic lineages within the M. tuberculosis complex (MTBC) and is an important cause of human (TB) in West Africa. The reasons for this geographic restriction remain unclear. Here, we performed a prospective study to explore associations between characteristics TB patients MTBC circulating Ghana.We genotyped 1,211 isolates recovered from pulmonary recruited 2012 2014 using single nucleotide polymorphism typing spoligotyping. Associations patient...
Abstract Mycobacterium africanum ( Maf) causes a substantial proportion of human tuberculosis in some countries West Africa, but little is known on this pathogen. We compared the genomes 253 Maf clinical isolates from Ghana, including N = 175 Lineage 5 (L5) and 78 6 (L6). found that genomic diversity L6 was higher than L5 despite smaller sample size. Regulatory proteins appeared to evolve neutrally under purifying selection L6. Even though over 90% T cell epitopes were conserved both...
Background Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. strains with hyper-virulence, MDR-TB disseminated disease makes it imperative to understand the biology pathogen. Methods (15) among 1755 complex (MTBC) isolated between 2012 2014 were characterized analyzed for associated patient demography other risk factors. Five isolates whole-genome sequenced comparatively against global collection...
Background Resistance to tuberculosis (TB) drugs has become a major threat global control efforts. Early case detection and drug susceptibility profiling of the infecting bacteria are essential for appropriate management. The objective this study was determine profiles difficult-to-treat (DTT) TB patients in Ghana. Methods Sputum samples obtained from DTT-TB cases health facilities across Ghana were processed rapid diagnosis resistance using Genotype MTBDR plus sl . v2 Hain Life science....
Background: Consistency among clinical symptoms, laboratory results and autopsy findings can be a quality measure in the diagnosis of coronavirus disease 2019 (COVID-19). There have been classic cases that met case definition COVID-19 but real-time reverse-transcription polymerase chain reaction (rRT-PCR) tests nasopharyngeal swabs were negative. Objectives: This study aimed to share pathological observations autopsies performed at 37 Military Hospital's Department Anatomical Pathology on...
The respiratory therapy (RT) profession in Ghana is a new and emerging field. Therefore, the purpose of this study was to assess evaluate RT as needs assessment help policymakers key stakeholders shape Ghana.
Background Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M. strains with hyper-virulence, MDR-TB disseminated disease makes it imperative to understand the biology pathogen. Methods (15) among 1755 complex (MTBC) isolated between 2012 2014 were characterized analyzed for associated patient demography other risk factors. Five whole-genome sequenced comparatively against global collection published...
Abstract Mycobacterium africanum ( Maf ) causes up to half of human tuberculosis in West Africa, but little is known on this pathogen. We compared the genomes 253 clinical isolates from Ghana, including both L5 and L6. found that genomic diversity L6 was higher than L5, selection pressures differed between groups. Regulatory proteins appeared evolve neutrally under purifying Conversely, T cell epitopes were positive Although only 10% variable, mutations mostly lineage-specific. Our findings...
Causes of death during the coronavirus disease 2019 (COVID-19) pandemic ranhttp://crossmark.crossref.org/dialog/?doi=10.4102/ajlm.v11i1.1766=pdf&date_stamp=2022-11-23ge from direct consequences severe acute respiratory syndrome 2 (SARS-CoV-2) infection to deaths unrelated SARS-CoV-2. Another feature is post-mortem testing for Understanding these aspects COVID-19 are essential in planning and limiting impact SARS-CoV-2 virus on healthcare systems.This study investigated underlying causes...