A5101489296- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Orthopedic Surgery and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Nerve Injury and Rehabilitation
- Retinoids in leukemia and cellular processes
- Ginseng Biological Effects and Applications
- Nerve injury and regeneration
- Spinal Hematomas and Complications
- Chemokine receptors and signaling
- Peripheral Nerve Disorders
- Pharmacological Effects of Natural Compounds
- Pain Management and Opioid Use
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Facial Nerve Paralysis Treatment and Research
- Renal and Vascular Pathologies
- Anesthesia and Pain Management
- Hip disorders and treatments
- Gastrointestinal motility and disorders
- Dental Anxiety and Anesthesia Techniques
- Pregnancy-related medical research
Second Affiliated Hospital of Soochow University
2015-2025
Soochow University
2015-2025
Lanzhou University
2022
First Hospital of Lanzhou University
2022
Yancheng First People's Hospital
2018
Nantong University
2018
Bone cancer pain (BCP) is a type of ongoing or breakthrough caused by primary bone tumor metastasis. BCP impairs patients' quality life. Depending upon clinical observations, the administration centrally acting analgesic has been associated with alleviation symptoms patients. Central nervous system sensitization performs crucial role in pain-regulating perception BCP. Nevertheless, precise neural circuitry and mechanism action remain enigmatic. In present study, we observed activation...
Lumbar disc herniation (LDH) is a common chronic orthopedic condition characterized by the protrusion of nucleus pulposus tissue, leading to low back and leg pain. Its pathophysiology remains poorly understood. The aim this study was investigate whether demethylase Fat mass obesity-associated protein (FTO) mediates local translation P2X3 receptors (P2X3R) in rat model LDH. effect process on excitability dorsal root ganglion (DRG) cells also examined, which may elucidate peripheral molecular...
Osteoporotic fractures typically exhibit delayed healing due to impaired cell recruitment, chronic inflammation, and disrupted neurovascular signaling. Sensory nerve signaling plays a crucial role in fracture repair, its deficiency is significant factor leading healing. Addressing these deficiencies overcoming the challenges associated with bone repair osteoporosis. In this study, smart composite hydrogel (denoted as OCS-MPC) was synthesized by embedding CGRP-functionalized...
Lumbar disc herniation (LDH) is a major cause of discogenic low back pain and sciatica, but the underlying mechanisms remain largely unknown. Hydrogen sulfide (H 2 S) becoming recognized for its involvement in wide variety processes including inflammation nociception. The present study was designed to investigate roles H S signaling pathway regulation expression function purinergic receptors (P2XRs) dorsal root ganglion (DRG) neurons from rats with LDH. LDH induced by implantation autologous...
Abstract The pathogenesis of pain in lumbar disc herniation (LDH) remains poorly understood. We have recently demonstrated that voltage-gated sodium channels (VGSCs) dorsal root ganglion (DRG) neurons were sensitized a rat model LDH. However, the detailed molecular mechanism for sensitization VGSCs largely unknown. This study was designed to examine roles endogenous hydrogen sulfide synthesizing enzyme cystathionine β -synthetase (CBS) previously validated Here we showed inhibition CBS...
Radicular pain, caused by a lesion or autologous nucleus pulposus (NP) implantation, is associated with alteration in gene expression of the pain-signaling pathways. lncRNAs have been shown to play critical roles neuropathic pain. However, mechanistic function lumbar disc herniation (LDH) remains largely unknown. Identifying different lncRNA under sham and NP-implantation conditions spinal cord important for understanding molecular mechanisms radicular pain.LDH was induced implantation (NP),...
This study was conducted to detect the expression of miR-19 and Pax6 (Paired box protein 6) in human osteosarcoma cells effects on biological characteristics cells. Quantitative real-time polymerase chain reaction used normal osteoblasts (hFOB 1.19) cell lines (U2OS, Saos-2, MG-63). Results showed that significantly upregulated compared with hFOB 1.19 cells, while messenger RNA downregulated. defined as target gene which validated by luciferase reporter analysis. indicated had an interaction...
<p>Osteosarcoma shows resistance to chemotherapy and many side effects. The ethyl acetate fraction of ethanolic extract Chrysophyllum cainito was taken in the present work. characterized for its phenolic content, antioxidant capacity (ferric reducing power 2,2-diphenyl-1-picrylhydrazyl assays), ability form reactive oxygen species annexin V assay. contained content 30.1 ± 0.2 mg GAE/g extract. Ferric assay DPPH showed 213.2 12.4 mM Fe<sup>2+</sup> equivalent per gram 85.6...
Smoking is associated with an increased risk of respiratory diseases, including lung cancer and asthma. However, the mechanisms or diagnostic markers for smoking-related diseases remain largely unknown. Here we investigated role cigarette smoke condensate (CSC) in regulation human bronchial epithelial cell (BEAS-2B) behavior. We found that exposure to CSC significantly inhibited BEAS-2B viability, impaired morphology, induced apoptosis, triggered oxidative damage, promoted inflammatory...
Osteoarthritis (OA) is a severe inflammation-related disease which leads to cartilage destruction. The retinoic acid receptor gamma (RARγ) has been indicated be involved in many inflammation processes. However, the role and mechanism of RARγ destruction caused by OA are still unknown. Here, we demonstrated that was highly expressed chondrocytes patients compared with healthy people positively correlated damage degree OA. Cytokine TNF-α promoted transcription expression through activating...
The study showed a case of missed diagnosis Leriche syndrome. Patients with intermittent claudication were diagnosed as lumbar spinal stenosis by local hospital MRI. When conservative treatment was ineffective, the patients treated in our spine clinic. However, MRI no significant stenosis, and arteriovenous ultrasound also abnormality. Vascular surgeons believed that patient’s symptoms had little correlation vascular lesions. After careful reading MRI, we found signal intensity abdominal...
Abstract urpose: This study aimed to compare total blood loss (TBL) and hidden (HBL) in patients undergoing single-level open transforaminal lumbar interbody fusion (O-TLIF) unilateral biportal endoscopic (ULIF). Methods: A of 28 who underwent ULIF 30 O-TLIF from March 2020 October 2021 were retrospectively reviewed. The Nadler’s formula was employed estimate the patient’s volume (PBV), Gross’s TBL, Sehat’s HBL. obtained data then analyzed with independent t test、chi-squared test, analysis...
Abstract Background At present, there are no new method for establishing operative channels the unilateral biportal endoscopic(UBE)system. Objective This paper describes a in UBE surgery. Meanwhile, we assessed preliminary efficacy of endoscopic discectomy (UBED) treating degenerative disc disease. Methods We retrospectively reviewed 52 patients who underwent UBED from February 2020 to August via our method. The Oswestry Disability Index (ODI) and visual analogue scale (VAS) score were...