A5103187309- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Bowel Disease
- Spondyloarthritis Studies and Treatments
- Lower Extremity Biomechanics and Pathologies
- Pharmaceutical studies and practices
- Psoriasis: Treatment and Pathogenesis
- Microscopic Colitis
- Musculoskeletal synovial abnormalities and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related molecular mechanisms research
- Laser Applications in Dentistry and Medicine
- Inflammatory mediators and NSAID effects
- Chronic Disease Management Strategies
- Asymmetric Hydrogenation and Catalysis
- Infrared Thermography in Medicine
- Knee injuries and reconstruction techniques
- Liver Disease Diagnosis and Treatment
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Nutrition, Genetics, and Disease
- Radiomics and Machine Learning in Medical Imaging
- Biosimilars and Bioanalytical Methods
- Hip disorders and treatments
- Bone Metabolism and Diseases
Gansu University of Traditional Chinese Medicine
2025
Southern Medical University
2021-2024
Hong Kong Polytechnic University
2023-2024
Zhujiang Hospital
2020-2024
East China Normal University
2022-2024
Clinical Research Management
2023
Takeda (United States)
2020-2021
Jiangxi Normal University
2018
Merck & Co., Inc., Rahway, NJ, USA (United States)
2011-2015
Spital Uster
2012
Objectives To develop and validate a nomogram to detect improved knee pain in osteoarthritis (OA) by integrating magnetic resonance imaging (MRI) radiomics signature of subchondral bone clinical characteristics. Methods Participants were selected from the Vitamin D Effects on Osteoarthritis (VIDEO) study. The primary outcome was 20% improvement score over 2 years participants administrated either vitamin or placebo. Radiomics features characteristics 216 extracted analyzed. randomly split...
Abstract Objective To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design. Methods Two-sample bi-directional MR analyses were performed summary-level information on OA traits from UK Biobank arcOGEN. Sensitivity including MR-Egger, simple median, weighted pleiotropy residual sum, outlier approaches utilized in conjunction with inverse variance weighting (IVW). Gene ontology (GO) enrichment expression...
An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters <italic>via</italic> benzylic C–N bond cleavage.
Objectives: We aimed to examine whether metformin (MET) use is associated with a reduced risk of total knee arthroplasty (TKA) and low severity pain in patients osteoarthritis (OA) diabetes and/or obesity. Methods: Participants diagnosed OA obesity from June 2000 July 2019 were selected the information system local hospital. Regular MET users defined as those recorded prescriptions or self-reported regular for at least 6 months. TKA was extracted patients’ surgical records. Knee assessed...
BackgroundLarge adulthood body size was associated with increased risk of osteoarthritis. We aimed to examine the association between trajectories from childhood and potential interactions genetic susceptibility on osteoarthritis risk.MethodsWe included participants UK Biobank aged 38–73 years in 2006–10. Childhood information collected by questionnaire. Adulthood BMI assessed transformed into three categories (<25 kg/m2 for normal, 25–29·9 overweight, >30 obesity). A Cox proportional...
This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA).BMLs were assessed by MRI Osteoarthritis Knee Score (MOAKS)≥2. Bulk RNA-sequencing (bulk-seq) BML-specific differentially expressed genes (DEGs) analysis performed among samples (including OA-BML=3, paired OA-NBML=3; non-OA=3). The hub BMLs identified verifying independent datasets multiple bioinformatic analyses. To further estimate...
ObjectivesTo investigate the longitudinal association between MRI-detected osteophyte scores and progression of knee symptoms, whether was modified in presence bone marrow lesions (BMLs) or effusion-synovitis.MethodsData from Vitamin D Effects on Osteoarthritis (VIDEO) study, a randomized, double-blinded placebo-controlled clinical trial symptomatic osteoarthritis (OA) patients, were analyzed as an exploratory study. Western Ontario McMaster Universities Index (WOMAC) used to assess...
To investigate whether the associations between cartilage defects and volumes with changes in knee symptoms were mediated by osteophytes.Data from Vitamin D Effects on Osteoarthritis (VIDEO) study analyzed as a cohort. The Western Ontario McMaster Universities Index was used to assess at baseline follow-up. Osteophytes, defects, measured using magnetic resonance imaging baseline. Associations morphology assessed linear regression models, mediation analysis test these osteophytes.A total of...
<h3>Background</h3> Ankylosing Spondylitis (AS) is a chronic, systemic disease that predominantly affects the axial skeleton with sacroiliac joints involvement as its hallmark, causing characteristic inflammatory back pain and resulting in varying degree of structural functional impairments. Subcutaneous biologic therapies are usually prescribed to patients active severe AS, who have responded inadequately conventional therapy. <h3>Objectives</h3> This study was conducted describe treatment...