To compare the prognostic performance between different comorbidity assessments of survival in patients with operated lung cancer. A total 4508 cancer treated by surgery 2003 and 2012 were identified through Taiwan's National Health Insurance Research Database. Information on pre-existing comorbidities prior to diagnosis was obtained adapted Charlson index, age-adjusted index (ACCI) Elixhauser scores. The influence analysed using a Cox proportional hazard model. discriminatory ability...

Cancer survival correlates not only with the features of primary malignancy but also degree underlying comorbidities. Of multiple methods used for evaluating impact comorbidities on survival, Charlson and Elixhauser are most common. This study compared these 2 comorbidity measures predicting in oral cancer patients. Using Taiwan National Health Insurance claims data (2008–2011), we acquired regarding patients' characteristics, comorbidities, from 3583 Comorbidity was classified according to...

Abstract Triple‐negative breast cancer (TNBC) exhibits a higher level of glycolytic capacity and are commonly associated with an inflammatory microenvironment, but the regulatory mechanism metabolic crosstalk between tumor microenvironment (TME) largely unresolved. Here, we show that glucose transporter 3 (GLUT3) is particularly elevated in TNBC metastatic progression poor prognosis patients. Expression GLUT3 crucial for promoting epithelial‐to‐mesenchymal transition enhancing invasiveness...

Purpose To characterize the impact of comorbidity on survival outcomes for patients with nasopharyngeal carcinoma (NPC) post radiotherapy (RT). Methods A total 4095 NPC treated by RT or plus chemotherapy (CT) in period from 2007 to 2011 were included through Taiwan's National Health Insurance Research Database. Information present prior diagnosis was obtained and adapted Charlson Comorbidity Index (CCI), Age-Adjusted (ACCI) a revised head neck index (HN-CCI). The prevalence influence...

Stereotactic body radiation therapy (SBRT) has been an emerging non-invasive treatment modality for patients with hepatocellular carcinoma (HCC) when curative treatments cannot be applied. In this study, we report our clinical experience Cyberknife SBRT unresectable HCC and evaluate the efficacy outcomes of highly sophisticated technology. Between 2008 2012, 115 treated were retrospectively analyzed. Doses ranged from 26 Gy to 40 given in 3 5 fractions consecutive days. The cumulative...

The aim of this study was to investigate the relationship between marital status and disease outcome in patients with surgically treated colon cancer. Between June 2010 December 2015, a total 925 newly diagnosed cancer receiving curative resection were enrolled. effect on 5-year disease-specific survival (DSS) calculated using Kaplan-Meier method, compared by log-rank tests. A Cox regression model used find significant independent variables determine whether marriage had benefit cancer,...

To evaluate the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) its effect on survival in patients with unresectable huge hepatocellular carcinoma (HCC) unsuitable other standard treatment option.Between 2009 2011, 22 HCC (≧10 cm) were treated SBRT. dose ranged from 26 Gy to 40 five fractions. Overall (OS) disease-progression free (DPFS) determined by Kaplan-Meier analysis. Tumor response toxicities also assessed.After a median follow-up 11.5 month (range 2-46...

Neoadjuvant concurrent chemoradiotherapy (CCRT), followed by radical proctectomy, is the standard treatment for locally advanced rectal cancer. However, a poor response and therapeutic resistance continue to occur despite this treatment. In study, we analyzed microarray datasets (GSE68204) of cancer from Gene Expression Omnibus database, identified CHD4 as one most significantly up-regulated genes among all subunits nucleosome remodeling histone deacetylation (NuRD) complex, in...

Dysregulated mitochondrial dynamics and metabolism play important roles in tumorigenesis. Metastasizing tumor cells predominantly utilize metabolism, regulators of metabolic reprogramming may provide reliable biomarkers for diagnosing cancer metastasis. Here, we identified a type I arginine methyltransferase-DEAD-box polypeptide 3, X-linked (PRMT1-DDX3) axis that promotes breast metastasis by coordinating biogenesis mitophagy to ensure quality control. Mechanistically, PRMT1 induces...

To compare the prognostic value of 3 different lymph node scoring systems " log odds positive nodes (LODDS), ratio (rN), and yield in an effort to improve staging oral cancer. We identified 3958 cancer patients from Surveillance, Epidemiology, End Results database 2007 2013. In univariate analysis, LODDS, pN, rN, were factors for 5-year disease-specific survival (DSS) overall (OS). Multivariate analysis indicated that with LODDS 4 had worst DSS OS. Stage migration occurred pN1 pN2 4....

The aim of this study was to investigate the relationship between textbook outcome and survival in patients with surgically treated colon cancer. A total 804 surgical cases were enrolled June 1, 2010 December 31, 2014. Textbook defined as who had cancer surgery met six healthcare parameters within 6 weeks, radical resection, lymph node (LN) yield ≥12, no ostomy, adverse colonoscopy before/after months. effect on 5-year disease-specific (DSS) calculated using Kaplan-Meier method. Cox...

Abstract Obesity is a well‐known risk factor for breast cancer formation and associated with elevated mortality poor prognosis. An obesity‐mediated inflammatory microenvironment conducive to the malignant progression of tumors. However, detailed molecular mechanism still needed be clarified. Herein, we identified that cells from mice diet‐induced obesity exhibited increased growth, invasiveness, stemness capacities. A transcriptome analysis revealed expressions interleukin 33 (IL33)...

Bladder preservation therapy is an alternative to radical cystectomy in patients with muscle-invasive bladder cancer (MIBC). The purpose of this study compare survival outcomes between and MIBC using Asian nationwide registry database.

Multimodal treatment involving preoperative chemoradiotherapy (CRT) followed by surgery is the current standard of care for rectal cancer. Despite advancements, risk recurrence, metastasis, and decreased survival remains high. This study aims to evaluate potential biomarkers stratify prognosis in patients with cancer undergoing CRT surgery. Through data mining receptor-binding pathways a published transcriptome cases, ITLN1 was identified as most relevant gene associated poor response...

Background/Aim: This study aimed at evaluating the potential benefit of automatic non-coplanar volumetric arc therapy (VMAT) (hyperarc, HA) technique in treating glioblastoma multiforme (GBM). Patients and Methods: Twenty-seven patients with GBM who received coplanar VMAT (C-VMAT) were selected this study. HA (NC-VMAT) plans generated same prescriptions constraints. The Target coverage, organs risk (OARs) dose, dosimetric indexes compared among three plans. Results: plan demonstrated a...

Radical cystectomy and bladder preservation therapy are effective for muscle-invasive cancer (MIBC); however, many patients over 70 medically unfit these options. For such patients, radiotherapy serves as a viable alternative. This study compares survival outcomes of versus supportive care in MIBC ineligible or with concurrent chemoradiotherapy. Using the Taiwan Cancer Registry National Health Insurance Research Database (2011-2020), we identified cT2-T4N0-1M0 urinary urothelial carcinoma....

Stereotactic body radiation therapy (SBRT) for inoperable hepatocellular carcinoma (HCC) offers excellent local control rates. This study retrospectively analyzed the influence of different tumor size on treatment outcomes after SBRT.Between December 2008 and February 2014, 141 HCC patients were treated with Cyberknife SBRT. Patients divided into 3 groups namely small tumors (≤4 cm), intermediate-sized (>4-<10 large (≥10 cm) tumors. Treatment outcomes, prognoses, safety at each compared...

Abstract Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC) patients. This study aims to determine whether combining radiotherapy with sorafenib administration increases its efficacy. The cohort included 4763 patients diagnosed HCC who received between January 2012 and December 2015, as reported in medical records Taiwan Cancer Registry database. effect of or without on survival was calculated using Kaplan–Meier method compared log-rank test. A Cox proportional...

Abstract Background To evaluate dosimetric differences of salvage irradiations using two commercially available volumetric modulated arc therapy (VMAT) stereotactic body radiation (SBRT) techniques: RapidArc (RA) and HyperArc (HA), for recurrent nasopharyngeal carcinoma (NPC) after initial therapy. Methods Ten patients with NPC status previously treated were considered suitable candidates SBRT VMAT approach. Two separate treatment plans created HA RA techniques each case, outcomes compared...

Background: Colorectal cancer is the third most common in both sex worldwide and it also fourth cause of mortality.For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy gold standard treatment for patients with stage II/III cancer.By data mining a documented database transcriptome (GSE35452) from Gene Expression Omnibus, National Center Biotechnology Information, we recognized that ALDOB was significantly up-regulated transcript among those...