A5023068003- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Chromatography in Natural Products
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Molecular spectroscopy and chirality
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- Pharmacological Effects of Natural Compounds
- Chemical Reaction Mechanisms
- Analytical chemistry methods development
- Antibiotics Pharmacokinetics and Efficacy
- Microbial bioremediation and biosurfactants
- Phytochemistry and biological activity of medicinal plants
- Advanced Chemical Sensor Technologies
- Enzyme Catalysis and Immobilization
- Synthetic Organic Chemistry Methods
- Synthesis of heterocyclic compounds
- Pesticide Residue Analysis and Safety
- Probiotics and Fermented Foods
- Medical research and treatments
- Coordination Chemistry and Organometallics
- Chemical Synthesis and Reactions
- Mesoporous Materials and Catalysis
Universitat de Barcelona
2009-2024
University of Genoa
2023
Institute for Research in Biomedicine
2005-2013
Barcelona Biomedical Research Park
2009
University of Vienna
2002-2004
John Wiley & Sons (Germany)
2001
Centre National de la Recherche Scientifique
1991-1992
Conservatoire National des Arts et Métiers
1991-1992
Laboratoire de Chimie
1992
Clínica Diagonal
1988
Mycobacterium sp. strain AP1 grew with pyrene as a sole source of carbon and energy. The identification metabolites accumulating during growth suggests that this initiates its attack on by either monooxygenation or dioxygenation at C-4, C-5 positions to give trans- cis-4,5-dihydroxy-4,5-dihydropyrene, respectively. Dehydrogenation the latter, ortho cleavage resulting diol form phenanthrene 4,5-dicarboxylic acid, subsequent decarboxylation 4-carboxylic acid lead degradation via phthalate. A...
A family of huprine-tacrine heterodimers has been developed to simultaneously block the active and peripheral sites acetylcholinesterase (AChE). Their dual site binding for AChE, supported by kinetic molecular modeling studies, results in a highly potent inhibition catalytic activity human AChE and, more importantly, vitro neutralization pathological chaperoning effect toward aggregation both β-amyloid peptide (Aβ) prion with key role protein. Huprine-tacrine take on added value that they...
Abstract The properties as chiral selector in HPLC stationary phases (CSPs) of a cellulose derivative bearing simultaneously 3,5-dimethylphenylamino carbonyl and 10-undecenoyl groups are described. This polysaccharide is reticulated (or bonded) on chromatographic supports such silica gel, previously treated or not, graphite alumina. thus obtained resistant to the usual solvents used liquid chromatography can be normal reversed phase conditions. results resolution racemic compounds with these...
A countercurrent chromatography protocol for support-free preparative enantiomer separation of the herbicidal agent 2-(2,4-dichlorphenoxy)propionic acid (dichlorprop) was developed utilizing a purposefully designed, highly enantioselective chiral stationary-phase additive (CSPA) derived from bis-1,4-(dihydroquinidinyl)phthalazine. Guided by liquid−liquid extraction experiments, solvent system consisting 10 mM CSPA in methyl tert-butyl ether and 100 sodium phosphate buffer (pH 8.0) identified...
Polar biotransformation products have been identified as causative agents for the eventual increase in genotoxicity observed after bioremediation of PAH-contaminated soils. Their further biodegradation has described under certain biostimulation conditions; however, underlying microorganisms and mechanisms remain to be elucidated. 9,10-Anthraquinone (ANTQ), a transformation product from anthracene (ANT), is most commonly detected oxygenated PAH (oxy-PAH) contaminated Sand-in-liquid microcosms...
Cinchona-derived anion-exchange-type chiral selectors have been adapted and employed in countercurrent chromatography (CCC) for the separation of enantiomers N-derivatized amino acids 2-aryloxypropionic acids. The accurate optimization enantioseparation terms solvent system composition, pH values, ionic strength, CCC operating conditions was performed. A wide range mixtures evaluated. Successful resolutions were achieved systems such as ammonium acetate buffer/tert-amyl...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic applications of 2-cyano-1,2,3,6-tetrahydropyridines. 2. Synthesis isodasycarpidone and related systems, the ervitsine skeleton its benzo analogJoan Bosch, Mario Rubiralta, Antonio Domingo, Jordi Bolos, Ana Linares, Cristina Minguillon, Mercedes Amat, Josep BonjochCite this: J. Org. Chem. 1985, 50, 9, 1516–1522Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1...
Abstract A structure‐guided redesign of D ‐fructose‐6‐phosphate aldolase from Escherichia coli (FSA) was devised for improving the acceptor tolerance towards α‐substituted and conformationally constrained aldehydes. FSA A129S/ R134X /A165G/S166G L107Y/A129G/ variants, where X R , V P or S were most suited biocatalysts dihydroxyacetone, hydroxyacetone glycolaldehyde additions to 20 N ‐Cbz‐aminoaldehydes (Cbz=benzyloxycarbonyl) including pyrrolidine piperidine derivatives. Full kinetic...
The aim of the present study is to develop selective extracting materials applicable a diversity fluoroquinolones. A series Molecularly Imprinted Materials (MIPs) were prepared in order choose nature monomer and that porogen together with its ratio cross-linker. non-regulated quinolone, Levofloxacin, was used as template avoid false positive results application. resulting MIPs evaluated MISPE experiments for Enrofloxacin. polymer using methyl acrylate (MA) MeOH/CHCl3 (1:1, v/v) provided...