A5019663881- Infectious Diseases and Mycology
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Actinomycetales infections and treatment
- Prostate Cancer Treatment and Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- DNA Repair Mechanisms
- Vascular Tumors and Angiosarcomas
- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunodeficiency and Autoimmune Disorders
- Molecular Biology Techniques and Applications
- TGF-β signaling in diseases
- Metallurgy and Material Science
- Bone Metabolism and Diseases
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Ruminant Nutrition and Digestive Physiology
- Viral Infections and Immunology Research
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Cancer-related gene regulation
National Institutes of Health
2014-2018
Dicle University
2016-2018
National Cancer Institute
2014-2018
La Ligue Contre le Cancer
2010
Centre National de la Recherche Scientifique
2007-2008
Université Claude Bernard Lyon 1
2006-2008
Institut National de la Recherche Agronomique du Niger
2008
École Pratique des Hautes Études
2006
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2006
Androgen deprivation therapy (ADT) targeting the androgen receptor (AR) is a standard therapeutic regimen for treating prostate cancer. However, most tumors progress to metastatic castration-resistant cancer after ADT. We identified type 1, 2, and 4 collagen-binding protein transforming growth factor-β (TGFβ)-induced (TGFBI) as an important factor in epithelial-to-mesenchymal transition (EMT) malignant progression of In cell lines, AR signaling stimulated activity transcription SPDEF, which...
// Man Kit Siu 1,2,* , Wassim Abou-Kheir 3,* Juan Yin 4,* Yung-Sheng Chang 1 Ben Barrett 4 Florent Suau Orla Casey Wei-Yu Chen 5 Lei Fang Paul Hynes Yao-Yu Hsieh 1,6,9 Yen-Nien Liu 1,7 Jiaoti Huang 8 and Kathleen Kelly Graduate Institute of Cancer Biology Drug Discovery, College Medical Science Technology, Taipei University, Taipei, Taiwan 2 Department Anesthesiology, Wan Hospital, 3 Anatomy, Cell Physiological Sciences Faculty Medicine, American University Beirut, Lebanon Branch, National...
Abstract In prostate cancer, Krüppel-like factor 4 (KLF4) depletion occurs frequently, suggesting a role as suppressor tumor. KLF4 is transcription associated with androgen receptor (AR) expression; however, its cellular functions and signaling regulation mechanism remain largely unknown. this study, we demonstrated that activated AR binds to the promoter enhances expression, which reciprocally targets promoter, thus sustaining activity. Ectopic expression in androgen-independent cancer...
Ovine pulmonary adenocarcinoma (OPA) is a lung cancer strikingly similar to the pneumonic-type mixed invasive with predominant bronchioloalveolar component in humans. Telomerase activity OPA and potential involvement of kinase Akt telomerase activation regulation cell proliferation were investigated. Lung tissues collected from sheep histopathological diagnosis or controls. Epithelial cultures derived vitro tissues. was evaluated using telomeric repeat amplification protocol method....
Abstract Pulmonary neuroendocrine cells (PNECs) which comprise less than 1% of airway epithelium were recently shown to be the cell origin for small lung cancer (SCLC). SCLC is most aggressive form human cancers and characterized by early dissemination or metastases features. We used immunohistochemistry (IHC) animal models in order delineate cellular hierarchy PNEC potentially leading cancer. PNECs first identified development (E12.5) as positive proneural basic helix-loop-helix...
Abstract Metastatic progression in patients with prostate cancer is common despite pharmacologic inhibition of androgen receptor signaling. This drug resistance associated increased signaling through the transforming growth factor-β (TGF-β) pathway. We found type I/II/IV collagen-binding protein (TGF-β)-induced (TGFBI) an important factor epithelial-to-mesenchymal transition (EMT) and malignant cancer. identified that androgen-responsive gene, SPDEF, navigates between AR TGFβ during to...
JSRV (jaagsiekte sheep retrovirus) is a betaretrovirus, infecting small ruminants. This virus responsible for the development of pulmonary adenocarcinoma, by transformation epithelial cells bronchioli and alveoli. animal cancer related to human bronchioloalveolar (BAC), specific form lung which viral etiology has been proposed several decades. In ruminants interacts with through Hyal2 receptor. genome simple does not contain already known oncogene. It now well established that envelope...