A5079683986- Prostate Cancer Treatment and Research
- Cancer, Stress, Anesthesia, and Immune Response
- Connective Tissue Growth Factor Research
- Fibroblast Growth Factor Research
- FOXO transcription factor regulation
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone health and treatments
Taipei Medical University
2017-2024
Institute of Biomedical Sciences, Academia Sinica
2001
Androgen deprivation therapy (ADT) targeting the androgen receptor (AR) is a standard therapeutic regimen for treating prostate cancer. However, most tumors progress to metastatic castration-resistant cancer after ADT. We identified type 1, 2, and 4 collagen-binding protein transforming growth factor-β (TGFβ)-induced (TGFBI) as an important factor in epithelial-to-mesenchymal transition (EMT) malignant progression of In cell lines, AR signaling stimulated activity transcription SPDEF, which...
Abstract Nerve growth factor (NGF) contributes to the progression of malignancy. However, functional role and regulatory mechanisms NGF in development neuroendocrine prostate cancer (NEPC) are unclear. Here, we show that an androgen-deprivation therapy (ADT)-stimulated transcription factor, ZBTB46, upregulated via ZBTB46 mediated-transcriptional activation . regulates NEPC differentiation by physically interacting with a G-protein-coupled receptor, cholinergic receptor muscarinic 4 (CHRM4),...
Neuroendocrine prostate cancer (PCa) (NEPC), an aggressive subtype that is associated with poor prognosis, may arise after androgen deprivation therapy (ADT). We investigated the molecular mechanisms by which ADT induces neuroendocrine differentiation in advanced PCa. found transmembrane protein 1 (MCTP1), has putative Ca 2+ sensing function and multiple -binding C2 domains, was abundant samples from patients MCTP1 expression of EMT-associated transcription factors ZBTB46, FOXA2, HIF1A. The...
Microsatellite instability (MSI) has been described in many human carcinomas, including gastric carcinomas (GCs). There are inconsistent findings regarding the association of MSI with various subsets GC specific clinicopathologic features. The objective this study was to define advanced at a genome-wide level and evaluate clinical relevance these patients.Forty-one adenocarcinomas serosa invasion (T3) were analyzed 59 loci that detected least one site per arm each autosome genome. expression...
The interaction between prostate cancer (PCa) cells and stromal fosters an immunosuppressive tumor microenvironment (TME) that promotes growth immune evasion. However, the specific signaling pathways involved remain unclear. We identified a key mechanism involving CXCL5/CXCR2 LIF/LIFR pathways, which create feedforward loop enhances neuroendocrine differentiation (NED) in PCa upregulates WNT1-inducible pathway protein 1 (WISP1) both cell types. WISP1 upregulation is essential for inducing...