A5028948207- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Ocular Oncology and Treatments
- Radiation Detection and Scintillator Technologies
- Glioma Diagnosis and Treatment
- Boron Compounds in Chemistry
- Nuclear Physics and Applications
- Bone Tumor Diagnosis and Treatments
- Retinal and Macular Surgery
- Ocular Infections and Treatments
- Head and Neck Surgical Oncology
- Glaucoma and retinal disorders
- Oral and Maxillofacial Pathology
- Medical Imaging Techniques and Applications
- Radiation Effects and Dosimetry
- Radiation Effects in Electronics
- Cancer and Skin Lesions
- Bladder and Urothelial Cancer Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Retinal Diseases and Treatments
- Sarcoma Diagnosis and Treatment
- Laser-Plasma Interactions and Diagnostics
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Particle accelerators and beam dynamics
Institut Curie
2011-2024
Université Paris Sciences et Lettres
2018-2024
Inserm
2024
Centre Hospitalier d'Orsay
1995-2007
To define the prognostic factors for local control and overall survival among 100 consecutive patients with chordoma of base skull or upper cervical spine treated by fractionated irradiation combining proton photon beams. Between December 1993 August 2002, (median age: 53 years [8 - 85], M/F sex ratio: 3/2) were a combination high-energy photons protons. The component was delivered at Centre de Protonthérapie d'Orsay (CPO) 201 MeV beam. median total dose to tumor volume 67 GyECo. With...
Abstract Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue damage resulting from radiotherapy treatments. This partners the inherent advantages of protons with gain in preservation observed upon irradiation narrow, spatially fractionated beams. In this study, whole brains (excluding olfactory bulb) Fischer 344 rats (n = 16) were irradiated at Orsay Therapy Center. Half animals received standard proton irradiation, while other half pMBRT same average...
Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness glioma bearing rats highly spatially modulated beams. Whole brains (excluding olfactory bulb) Fischer 344 were irradiated. Four groups animals considered: group (RG2 rats), second RG2 tumor-bearing and third normal that received pMBRT (70 Gy peak dose one...
Purpose: Proton minibeam radiation therapy (pMBRT) is a new radiotherapy (RT) approach that allies the inherent physical advantages of protons with normal tissue preservation observed when irradiated submillimetric spatially fractionated beams. This dosimetry work aims at demonstrating feasibility technical implementation pMBRT. has been performed Institut Curie ‐ Therapy Center in Orsay. Methods: minibeams (400 and 700 μm‐width) were generated by means brass multislit collimator....
Abstract Radiotherapy (RT) is one of the most frequently used methods for cancer treatment. Despite remarkable advancements in RT techniquesthe treatment radioresistant tumours (i.e. high-grade gliomas) not yet satisfactory. Finding novel approaches less damaging normal tissues utmost importance. This would make it possible to increase dose applied tumours, resulting an improvement cure rate. Along this line, proton minibeam radiation therapy (pMBRT) a strategy that allows spatial modulation...
Abstract Proton minibeam radiation therapy (pMBRT) is a novel dose delivery method based on spatial fractionation. pMBRT has been shown to be promising in terms of reduced side effects and superior tumour control high-grade glioma-bearing rats compared standard irradiation. These findings, together with the recent optimized implementation clinical pencil beam scanning system, have triggered reflection possible application patient treatments. In this context, present study was designed...
The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms peak current and duration irradiation. In this paper we present implementation a beam transport system shape proton generated by laser-target interaction for vitro biological samples. A set four permanent magnet quadrupoles used focus beam, efficiently shaping spectrum providing large relatively uniform surface. Real time, absolutely calibrated,...
Proton minibeam radiation therapy (pMBRT) is an innovative approach that combines the advantages of with more precise ballistics protons to further reduce side effects radiation. One main challenges this generation very narrow proton pencil beams adequate dose-rate treat patients within a reasonable treatment time (several minutes) in existing clinical facilities. The aim study was demonstrate feasibility implementing pMBRT by combining beam scanning (PBS) technique use multislit...
Monte Carlo calculations are increasingly used to assess stray radiation dose healthy organs of proton therapy patients and estimate the risk secondary cancer. Among particles, neutrons primary concern due their high relative biological effectiveness. The validation simulations for out-of-field neutron doses remains however a major challenge community. Therefore this work focused on developing global experimental approach test reliability MCNPX models two installations operating at 75 178...
This paper presents the main results of a Monte Carlo simulation describing Orsay Proton Therapy Center (CPO) beam line. The project aimed to obtain prediction dose distribution in water phantom within 2% accuracy value and 2 mm range. tool used was MCNPX, version 2.5.0, included all elements CPO A new algorithm multiple Coulomb scattering has been incorporated resulting better spatial absolute values deposited energy. simulations 3D profiles show very good agreement with measured data 2%....
Responses of Fuji Imaging Plates (IPs) to proton have been measured in the range 1-200 MeV. Mono-energetic protons were produced with 15 MV ALTO-Tandem accelerator Institute Nuclear Physics (Orsay, France) and, at higher energies, 200-MeV isochronous cyclotron Institut Curie—Centre de Protonthérapie d’Orsay France). The experimental setups are described and photo-stimulated luminescence responses for MS, SR, TR IPs presented compared existing data. For interpretation results, a sensitivity...
We present an experimental procedure for the determination and verification under practical conditions of physical computational parameters used in our proton pencil beam algorithm. The calculation dose delivered by a single relies on measured spread‐out Bragg peak, description its radial spread at depth features simple specific accounting individually influence line as whole, energy modulation, compensator, patient medium. For determining values related to scattering, we utilized relation...
<i>Introduction:</i> Exudation from the tumour scar and glaucoma can be major problems after proton beam irradiation of uveal melanoma sometimes lead to secondary enucleation. We conducted a randomized study determine whether systematic transpupillary thermotherapy (TTT) radiotherapy could have beneficial effect. <i>Patients Method:</i>Between February 1999 April 2003, all patients treated by for melanomas ≧7 mm thick or ≧15 in diameter were included this giving their...
Small diamond detectors are useful for the dosimetry of high-energy proton beams. However, linear energy transfer (LET) dependence has been observed in literature with such solid state detectors. A novel synthetic detector recently become commercially available from manufacturer PTW-Freiburg (PTW microDiamond type 60019). This study was designed to thoroughly characterize four clinical beams, order investigate their response and reproducibility high LET regions. Very good dosimetric...
Abstract The biology underlying proton minibeam radiation therapy (pMBRT) is not fully understood. Here we aim to elucidate the biological effects of pMBRT using Fourier Transform Infrared Microspectroscopy (FTIRM). In vitro (CTX-TNA2 astrocytes and F98 glioma rat cell lines) in vivo (healthy F98-bearing Fischer rats) irradiations were conducted, with conventional radiotherapy pMBRT. FTIRM measurements performed at ALBA Synchrotron, multivariate data analysis methods employed assess spectral...