A5068790637- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Bioinformatics and Genomic Networks
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Hair Growth and Disorders
- Fungal Biology and Applications
- Hypothalamic control of reproductive hormones
- Drug-Induced Hepatotoxicity and Protection
- Healthcare and Venom Research
- Liver Disease Diagnosis and Treatment
- Protein Structure and Dynamics
- Ziziphus Jujuba Studies and Applications
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Free Radicals and Antioxidants
- Estrogen and related hormone effects
- PI3K/AKT/mTOR signaling in cancer
Wonkwang University
2023-2025
Woosuk University
2024-2025
Dongguk University
2022-2024
Gachon University
2019-2023
Samsung Medical Center
2016
Sungkyunkwan University
2016
Daejeon University
2013
Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods decipher the potential mechanisms of THM. To conduct THM-network (THM-NP) studies, different tools and databases for constructing analyzing herb–compound–target networks. In this study, we attempted capture methodological trends in THM-NP research. We identified studies visualized combinatorial...
Network pharmacology has emerged as a powerful tool to understand the therapeutic effects and mechanisms of natural products. However, there is lack comprehensive evaluations network-based approaches for products on identifying key mechanisms.
Cordyceps militaris is a well-known medicinal mushroom. It non-toxic and has clinical health benefits including cancer inhibition. However, the anticancer effects of C. cultured in brown rice on breast have not yet been reported. In this study, we simultaneously investigated cordycepin an extract MCF-7 human cells using cell viability assay, staining with Hoechst 33342, image-based cytometric assay. The concentrate exhibited significant inhibitory effects, its IC50 value was 73.48 µg/mL....
Acute and chronic liver disease are global problems with high morbidity mortality. Bupleuri Radix (BR) is an herbal medicine that has been prescribed empirically in traditional Asian to modulate metabolism. However, its active compounds therapeutic mechanisms remain unclear. Here, we integrated a network-based approach experimental validation elucidate BR's potential treating oxidative injury. Our incorporated data collection network construction utilizing bioinformatics tools, identified...
Centipeda minima (L.) A. Braun & Asch is a well-studied plant in Chinese medicine that used for the treatment of several diseases. A recent study has revealed effects extract Cetipeda (CMX) standardized by brevilin inducing hair growth. However, mechanism action CMX human follicle dermal papilla cells (HFDPCs) not yet been identified. We aimed to investigate molecular basis underlying effect on growth HFDPCs. induced proliferation HFDPCs, and transcript-level expression Wnt family member...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of intestinal barrier. The barrier maintained tight junctions (TJs), which sustain homeostasis and prevent pathogens from entering microbiome mucosal tissues. Ziziphus jujuba Miller (Z. jujuba) natural substance that has been used in traditional medicine as therapy for variety diseases. However, IBD, efficacy Z. unknown. Therefore, we evaluated ZJB Caco2 cells dextran sodium sulfate (DSS)-induced...
A computational approach to identifying drug–target interactions (DTIs) is a credible strategy for accelerating drug development and understanding the mechanisms of action small molecules. However, current methods predict DTIs have mainly focused on simple interactions, requiring further experiments understand mechanism drug. Here, we propose AI-DTI, novel method that predicts activatory inhibitory by combining mol2vec genetically perturbed transcriptomes. We trained model large-scale with...
Syndrome differentiation and disease diagnosis are central to Traditional Asian Medicine (TAM) because they guide personalized treatment. Yet, most TAM courses give students few structured opportunities practise these paired skills. We developed Gen-SynDi, a knowledge-guided generative-AI framework that links syndrome with improve training. Using standardized patient files from the National Institute for Korean Development, we built fatigue-focused dataset covering five Western-defined...
Tacrine, an FDA-approved acetylcholinesterase inhibitor, has shown efficacy in treating Alzheimer's disease, but its clinical use is limited by hepatotoxicity. This study investigates the protective effects of red ginseng against tacrine-induced hepatotoxicity, focusing on oxidative stress.
Network pharmacology has gained significant traction as a tool for identifying the mechanisms and therapeutic effects of herbal medicines. However, despite usefulness these approaches, their diversity underscores critical need systematic evaluation to ensure consistency reliability.
Isoquercitrin, a flavonoid glycoside found in various plants, has demonstrated antioxidant, anti-inflammatory, and anticancer properties. However, its hepatoprotective effects underlying mechanisms against oxidative liver injury remain unclear. In this study, we evaluated the antioxidant of isoquercitrin using integrated silico, vitro, vivo approaches. HepG2 cells exposed to arachidonic acid (AA) iron exhibited stress-induced apoptosis, which was significantly attenuated by treatment, as...
Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic and lacks guaranteed pharmacological therapeutic options. In this study, we applied a network-based framework for comprehensively identifying candidate flavonoids prevention and/or treatment NAFLD. Flavonoid-target interaction information was obtained from combining experimentally validated data results using recently developed machine-learning model, AI-DTI. Flavonoids were then prioritized by calculating network...
Chung-Sang-Bo-Ha-Hwan (CSBHH) is an herbal prescription widely used to treat various chronic respiratory diseases. To investigate the system-level treatment mechanisms of CSBHH in tract diseases, we identified 56 active ingredients and evaluated degree overlap between their targets disease-associated proteins. We then investigated disease-related signaling pathways associated with targets. Enrichment analysis showed that were significantly related inflammation, alveolar structure, tissue...
Forsythiaside A (FA) is an active constituent isolated from Forsythia suspensa, a beneficial herb used in traditional medicine known for its antioxidant and anti-inflammatory properties. Although various studies have suggested that FA has the protective effects, impacts on arachidonic acid (AA) plus iron vitro models carbon tetrachloride (CCl₄)-induced mouse liver damage vivo not been explored. In this study, HepG2 cells were subjected to AA + treatment induce apoptosis mitochondrial...
Janus kinase 3 (JAK3) inhibitors have been used effectively in the treatment of several cases alopecia universalis and its variants. Our study aims to evaluate whether emulsion extract brevilin A from Centipeda minima (CMX) stimulates hair regrowth a clinical trial, as JAK3 inhibitor, combined with network pharmacology-based analysis. CMX showed potent inhibition concentration-dependent manner. Significant differences total count, terminal anagen count baseline 24 weeks were observed between...
This study was conducted to evaluate the biological activities of Pueraria lobata (PL) on menopause-related metabolic diseases and explore underlying mechanism PL by network pharmacological analyses. We used ovariectomized (OVX) rats as a postmenopausal model administered at different doses (50, 100, 200 mg/kg). In OVX rats, decreased uterine weights PPAR-γ (peroxisome proliferator-activated receptor-gamma) mRNA expression in thigh muscle were significantly recovered after administration....
This study aimed at determining the effect of herbal mixture estrogen inhibition formula (EIF) and its possible mechanisms by precocious puberty animal models network pharmacology-based analysis.Precocious were established a single injection 300 μg danazol, then female rats administered EIF, vaginal openings monitored, uterus pituitary indices determined. The levels ALP, E2, LH, FSH measured using ELISA kits. Real-time PCR was performed to evaluate mRNA expression GnRH, UNC5C, netrin-1 in...
Hepatocellular carcinoma (HCC) has a high incidence and is one of the highest mortality cancers when advanced stage proceeded. However, Anti-cancer drugs available for treatment are limited new anti-cancer ways to treat them minimal. We examined that effects possibility Red Ginseng (RG, Panax ginseng Meyer) as drug on HCC by combining network pharmacology molecular biology. Network pharmacological analysis was employed investigate systems-level mechanism RG focusing HCC. Cytotoxicity...
Postmenopausal osteoporosis is a major global health concern, particularly affecting aging women, and necessitates innovative treatment options. Herbal medicine, with its multi-compound, multi-target characteristics, offers promising approach for complex diseases. In this study, we applied multiscale network random walk-based analyses to identify candidate herbs their active ingredients postmenopausal osteoporosis, focusing on underlying mechanisms. A dataset of medicinal herbs, ingredients,...
Despite the importance of accurate Sasang type diagnosis, a unique form Korean medicine, there have been concerns about consistency among diagnoses. We investigate data-driven integrative diagnostic model by applying machine learning to multicenter clinical dataset with comprehensive features.Extremely randomized trees (ERT), support vector machines, multinomial logistic regression, and K-nearest neighbor were applied, performances evaluated cross-validation. The feature classifier was...
Alzheimer's disease (AD) is a representative cause of dementia and caused by neuronal loss, leading to the accumulation aberrant neuritic plaques formation neurofibrillary tangles. Oxidative stress involved in impaired clearance amyloid beta (Aβ), Aβ-induced oxidative causes AD inducing Hwangryunhaedok-tang (HHT, Kracie K-09