A5103262401- Education and Learning Interventions
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Educational Systems and Policies
- Food Quality and Safety Studies
- Educational Research and Pedagogy
- Genomics and Phylogenetic Studies
- Digital Rights Management and Security
- Diverse Approaches in Healthcare and Education Studies
- Gene expression and cancer classification
- Technology and Data Analysis
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Education, Safety, and Science Studies
- Molecular Biology Techniques and Applications
- Innovation in Digital Healthcare Systems
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Genomics and Diagnostics
- Chinese history and philosophy
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Image Retrieval and Classification Techniques
- Nutrition, Health and Food Behavior
Korea Research Institute of Bioscience and Biotechnology
2016-2025
Dongguk University
2014-2025
Inje University
2022-2023
Pohang University of Science and Technology
2016
Hanyang University
2008-2016
Seoul National University
2014
Ewha Womans University
2014
Pusan National University
2011-2013
Gachon University
2013
Pukyong National University
2011
Abstract Plant leaves, harvesting light energy and fixing CO2, are a major source of foods on the earth. Leaves undergo developmental physiological shifts during their lifespan, ending with senescence death. We characterized key regulatory features leaf transcriptome aging by analyzing total- small-RNA transcriptomes throughout lifespan Arabidopsis (Arabidopsis thaliana) leaves at multidimensions, including age, RNA-type, organelle. Intriguingly, senescing showed more coordinated temporal...
Three-dimensional (3D) chromatin structure is an emerging paradigm for understanding gene regulation mechanisms. Hi-C (high-throughput conformation capture), a method to detect long-range interactions, allows extensive genome-wide investigation of 3D structure. However, broad application data have been hindered by the level complexity in processing and large size raw sequencing data. In order overcome these limitations, we constructed database named 3DIV (a 3D-genome Interaction Viewer...
We propose a novel, efficient and intuitive approach of estimating mRNA abundances from the whole transcriptome shotgun sequencing (RNA-Seq) data. Our method, NEUMA (Normalization by Expected Uniquely Mappable Area), is based on effective length normalization using uniquely mappable areas gene isoform models. Using known sequence model such as RefSeq, pre-computes numbers all possible gene-wise isoform-wise informative reads: former being sequences mapped to isoforms single exclusively...
Deep sequencing techniques provide a remarkable opportunity for comprehensive understanding of tumorigenesis at the molecular level. As omics studies become popular, integrative approaches need to be developed move from simple cataloguing mutations and changes in gene expression dissecting nature carcinogenesis systemic level complex networks that lead cancer development.Here, we describe high-throughput, multi-dimensional study primary lung adenocarcinoma tumors adjacent normal tissues six...
Chaeyoung Lee, Man-Soo Choi, Hyun-Tae Kim, Hong-Tai Yun, Byungwook Young-Soo Chung, Ryan W. and Hong-Kyu Choi. Plant Breeding Biotechnology -0001;3:179-96. https://doi.org/10.9787/PBB.2015.3.3.179
Abstract Despite substantial advances in disease genetics, studies to date have largely focused on individuals of European descent. This limits further discoveries novel functional genetic variants other ethnic groups. To alleviate the paucity East Asian population genome resources, we established Korean Variant Archive 2 (KOVA 2), which is composed 1896 whole-genome sequences and 3409 whole-exome from healthy ethnicity. largest database date, surpassing 1909 deposited gnomAD. The KOVA...
Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic expression. However, unraveling pathogenicity cancer remains a challenge since closer examinations have been greatly limited due lack appropriate tools specialized for disorganized higher-order chromatin structure. Here, we updated 3D-genome Interaction Viewer...
A wave of new technologies has created opportunities for the cost-effective generation high-throughput profiles biological systems, foreshadowing a "data-driven science" era. The large variety data available from research is also rich resource that can be used innovative endeavors. However, we are facing considerable challenges in big deposition, integration, and translation due to complexity its production at unprecedented exponential rates. To address these problems, 2020, Korean...
이 연구는 2022 개정 교육과정에서 전문 공통과목으로 신설되는 '노동 인권과 산업 안전 보건' 과목의 인식과 각론의 학습 영역 및 요소를 기반으로 지원 확산을 위한 기초자료를 BR/제공하고자 한다. 연구 목적 달성을 위해 과목을 가르칠 예정인 교사 588명을 대상으로 조사를 실시하였고, 중 492부를 분석하였다.BR/ 구체적인 결과는 다음과 같다. 첫째, 교사들은 노동 보건과 관련된 연수를 이수하지 않거나 정부부처 중심으로 제한적으로만 이수하고 있었다. 둘째, 과목이 확산될 수 있는 공감대가 조성되었지만, 관련 운영하기 교육과정 운영상의 논의가 필요하다. 셋째, 확산 방법으로 교사의 전문성을 제고하기 교과서 교수・학습 보조자료 개발 지원과 연수의 개설 확대가 시급하다. 넷째, 교육요구도 The Locus for Focus Model을 활용하여 분석한 결과, 실천적 지식을 제공하는 학습영역 요소에 대한 교육요구도와 우선순위가 높은 것으로 조사되었다. BR/ 이상의 내용을...
The purpose of this study is to identify the relationship between career preparation behavior types Meister High School students and their labor market outcomes after graduation, thereby illuminating characteristics transition effectiveness education. Career factors were identified, latent profile derived based on level each factor's implementation. Differences in across these then analyzed. main findings are as follows: First, behaviors categorized into three components: exploration, skill...
Spatial transcriptomics holds great promise for revolutionizing biology and medicine by providing gene expression profiles with spatial information. Until recently, resolution has been limited, but advances in high-throughput situ imaging technologies now offer new opportunities covering thousands of genes at a single-cell or even subcellular resolution, necessitating databases dedicated to comprehensive coverage analysis user-friendly intefaces. We introduce the HISSTA database, which...
Syndrome differentiation and disease diagnosis are central to Traditional Asian Medicine (TAM) because they guide personalized treatment. Yet, most TAM courses give students few structured opportunities practise these paired skills. We developed Gen-SynDi, a knowledge-guided generative-AI framework that links syndrome with improve training. Using standardized patient files from the National Institute for Korean Development, we built fatigue-focused dataset covering five Western-defined...
Abstract During the last decade, generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges, including access to human data, as well transfer, storage, sharing enormous amounts data. To promote data-driven biological research, Korean government announced that all generated from government-funded research projects should be deposited at Korea BioData Station (K-BDS), which consists multiple databases for individual types. Here, we introduce...
The general method used to determine the function of newly discovered proteins is transfer annotations from well-characterized homologous proteins. process selecting can largely be classified into sequence-based and domain-based approaches. Domain-based methods have several advantages for identifying distant homology among with multiple domains, as compared methods. However, these are challenged by large families defined 'promiscuous' (or 'mobile') domains.Here we present a measure, called...
Recently, thread-embedding therapy (TET) has been widely applied in Korean medicine for cosmetic purposes such as reducing skin wrinkles. An inserted thread was reported to have induced continuous stimulation, followed by support connective tissue regeneration. However, the potential role of TET hairgrowth not yet reported.We designed this study evaluate whether a hair-growth-promoting effect. C57 black 6 (C57BL/6) mice were divided into three groups: normal saline-treated,...
While next-generation sequencing (NGS) costs have fallen in recent years, the cost and complexity of computation remain substantial obstacles to use NGS bio-medical care genomic research. The rapidly increasing amounts data available from new high-throughput methods made processing infeasible without automated pipelines. integration analytic resources into workflow systems provides a solution problem by simplifying task analysis. To address this challenge, we developed cloud-based management...
Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform quantitative genetic analysis chromatin accessibility, we obtained open profiles across 96 genetically different yeast strains by FAIRE (formaldehyde-assisted isolation regulatory elements) assay followed sequencing. While 5∼10% region (OCRs) were significantly affected variations in their underlying sequences, subtelomeric areas as well gene-rich...
Abstract High-throughput screening based on CRISPR-Cas9 libraries has become an attractive and powerful technique to identify target genes for functional studies. However, accessibility of public data is limited due the lack user-friendly utilities up-to-date resources covering experiments from third parties. Here, we describe iCSDB, integrated database CRISPR using human cell lines. We compiled two major sources screening: DepMap portal BioGRID ORCS. itself that includes three large-scale...
Abstract Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs tissues. Thus, in vitro serve as a superior alternative conventional lines animal models drug development regenerative medicine. For simple reproducible analysis of the quality compensate for shortcomings existing experimental validation studies, quantitative evaluation method should be developed. Here, using GTEx database, we construct calculation system assess similarity...
[Purpose] The purpose of the present study was to investigate effect magnetic infrared laser (MIL) radiation on xylene-induced acute inflammation. [Subjects] subject animals were male ICR mice. [Methods] Mice once irradiated (60s) by MIL at 1.33, 2.66 or 6.65 J/cm2 MIL, treated with indomethacin dexamethasone. Then xylene (0.03 ml) topically applied anterior surface right ear induced inflammation 1 h after irradiation MIL. changes in weights, histological profiles and histomorphometrical...
Numerous genetic variations have been found to be related human diseases. Significant portion of those affect the drug response as well by changing protein structure and function. Therefore, it is crucial understand trilateral relationship among genomic variations, diseases drugs. We present drugs (VnD), a consolidated database containing information on diseases, genes structures information. VnD was built in three steps. First, we integrated various resources systematically deduce catalogs...
Aging is a complex and challenging phenomenon that requires interdisciplinary efforts to unravel its mystery. Insight into genes relevant the aging process would offer chance delay avoid some of deteriorative aspects through use preventive methods. To assist basic research on aging, comprehensive database analysis platform for aging-related required.We developed web-based server, called Gerontome contains gene information user-friendly pipelines. construct database, we integrated their...
Cancer cell lines are essential components for biomedical research. However, proper choice of experimental purposes is often difficult because genotype and/or expression data missing or scattered in diverse resources. Here, we report Gene Expression and Mutations Cell Lines (GEMiCCL), an online database human cancer that provides information. We have collected mutation, gene copy number variation (CNV) from three representative databases on lines—Cancer Line Encyclopedia , Catalogue Somatic...