Hsin‐Han Lee

ORCID: 0000-0003-3904-8004
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Research Areas
  • Magnetic properties of thin films
  • Plant Pathogens and Fungal Diseases
  • Advanced Memory and Neural Computing
  • Mycorrhizal Fungi and Plant Interactions
  • Ferroelectric and Negative Capacitance Devices
  • Genomics and Phylogenetic Studies
  • Yeasts and Rust Fungi Studies
  • Graphene research and applications
  • Molecular Junctions and Nanostructures
  • Nematode management and characterization studies
  • Mycotoxins in Agriculture and Food
  • Quantum and electron transport phenomena
  • Topological Materials and Phenomena
  • Semiconductor materials and devices
  • Forest Ecology and Biodiversity Studies
  • Environmental DNA in Biodiversity Studies
  • Parasite Biology and Host Interactions
  • Horticultural and Viticultural Research
  • Organic Light-Emitting Diodes Research
  • Fungal Biology and Applications
  • Carbon Nanotubes in Composites
  • Legume Nitrogen Fixing Symbiosis
  • Fermentation and Sensory Analysis
  • Magnetic Field Sensors Techniques
  • Molecular Biology Techniques and Applications

Industrial Technology Research Institute
2017-2025

Biodiversity Research Center, Academia Sinica
2019-2024

National Taiwan University
2012-2023

Institute of Information Science, Academia Sinica
2021-2023

ITRI International
2022

Academia Sinica
2022

National Tsing Hua University
2007-2008

The ecology and genetic diversity of the model yeast Saccharomyces cerevisiae before human domestication remain poorly understood. Taiwan is regarded as part this yeast's geographic birthplace, where most divergent natural lineage was discovered. Here, we extensively sampled broadleaf forests across continental island to probe ancestral species’ diversity. We found that S. distributed ubiquitously at low abundance in forests. Whole-genome sequencing 121 isolates revealed nine distinct...

10.1101/gr.276286.121 article EN cc-by-nc Genome Research 2022-03-31

Obtaining sufficient genetic material from a limited biological source is currently the primary operational bottleneck in studies investigating biodiversity and genome evolution. In this study, we employed multiple displacement amplification (MDA) Smartseq2 to amplify nanograms of genomic DNA mRNA, respectively, individual Caenorhabditis elegans. Although reduced coverage was observed repetitive regions, produced assemblies covering 98% reference using long-read sequences generated with...

10.1093/nar/gkad647 article EN cc-by-nc Nucleic Acids Research 2023-08-01

Significance We present the genomes of five new bonnet mushroom Mycena species, formerly last fungal bioluminescent lineage lacking reference genomes. These genome-scale datasets allowed us to construct an evolutionary model pinpointing all possible changes in luciferase cluster across fungi and additional genes involved bioluminescence. show that clusters were differentially lost different lineages particular a substantial loss was observed mycenoid lineage. This can be attributed genome...

10.1073/pnas.2010761117 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2020-11-23

Since the 1990s, brown root rot caused by Phellinus noxius (Corner) Cunningham has become a major tree disease in Taiwan. This fungal pathogen can infect more than 200 hardwood and softwood species, causing gradual to fast decline of trees. For effective control, we must determine how is disseminated new infection center established. We performed Illumina sequencing de novo assembly single basidiospore isolate Daxi42 obtained draft genome ~40 Mb. By comparing 12,217 simple sequence repeat...

10.1371/journal.pone.0139445 article EN cc-by PLoS ONE 2015-10-20

The order Hymenochaetales of white rot fungi contain some the most aggressive wood decayers causing tree deaths around world. Despite their ecological importance and impact diseases they cause, little is known about evolution transmission patterns these pathogens. Here, we sequenced undertook comparative genomic analyses genomes using brown root fungus Phellinus noxius, wood-decomposing lamaensis, laminated sulphurascens trunk pathogen Porodaedalea pini. Many gene families lignin-degrading...

10.1111/mec.14359 article EN Molecular Ecology 2017-09-19

In this letter, we present a novel step spin-orbit torque magnetic random access memory (SOT-MRAM) cell structure and its switching behavior. A special stop-on-MgO etch etches away the hard mask pinned layer while retaining free (FL) MgO as part of cell. The extended Ta/CoFeB/MgO is proved to be more tolerant etching non-uniformity Ta nanowire improve yield. Although stops on MgO, FL underneath thin has been rendered non-magnetic by process. Recessed Cu pads were added nanowire, which...

10.1109/led.2018.2856518 article EN IEEE Electron Device Letters 2018-07-17

Abstract High-throughput sequencing has enabled genome skimming approaches to produce complete mitochondrial genomes (mitogenomes) for species identification and phylogenomics purposes. In particular, the portable device from Oxford Nanopore Technologies (ONT) potential facilitate hands-on training sampling interpretation of mitogenomes. this study, we present results six gastropod mitogenomes ( Aplysia argus, Cellana orientalis, toreuma, Conus ebraeus, miles Tylothais aculeata ) a graduate...

10.1038/s41598-022-14121-0 article EN cc-by Scientific Reports 2022-06-15

Aphelenchoides besseyi is a plant-parasitic nematode (PPN) in the family Aphelenchoididae capable of infecting more than 200 plant species. A. also species complex with strains exhibiting varying pathogenicity to plants. We present genome and annotations six species, four which belonged complex. Most genomes have size 44.7-47.4 Mb are among smallest clade IV, exception fujianensis, has 143.8 one largest. Phylogenomic analysis successfully delimited into oryzae pseudobesseyi revealed...

10.1111/1755-0998.13752 article EN cc-by-nc Molecular Ecology Resources 2023-01-04

Abstract Unipolar magnetic random‐access memory (U‐MRAM) enables high‐density integration of the ultimate 4F 2 one diode and tunneling junction architecture, essential for future data storage. Compared to conventional bipolar switching, U‐MRAM can improve storage density reduce overhead peripheral circuits. While recent U‐MRAMs show promising properties, their stochastic switching requires complex write‐and‐verify steps write error rate. This paper presents a novel design achieving reliable...

10.1002/adfm.202503318 article EN cc-by-nc-nd Advanced Functional Materials 2025-04-10

Abstract Neuromorphic diffusion models have become one of the major breakthroughs in field generative artificial intelligence. Unlike discriminative that been well developed to tackle classification or regression tasks, aim at creating content based upon contexts learned. However, more complex algorithms these result high computational costs using today’s technologies. Here, we develop a spintronic voltage-controlled magnetoelectric memory hardware for neuromorphic process. The in-memory...

10.1038/s41467-025-58932-x article EN cc-by Nature Communications 2025-05-30

We have developed a manufacturing-friendly spin-orbit torque magnetic random access memory (SOT-MRAM) technology in CMOS compatible 8-inch fab process. The proposed SOT-MRAM process resolves etching non-uniformity and reduction of high resistivity heavy-metal nanowire resistance issues. Besides, we present device size-dependent switching current threshold the cell structure. To realize potential our fabricated SOT-MRAM, wafer-level uniformity, cycling temperature dependence SOT been...

10.1109/jeds.2020.2971892 article EN cc-by IEEE Journal of the Electron Devices Society 2020-01-01

Comparative genomics of fungal mitochondrial genomes (mitogenomes) have revealed a remarkable pattern rearrangement between and within major phyla owing to horizontal gene transfer recombination. The role recombination was exemplified at finer evolutionary time scale in basidiomycetes group fungi as they display diversity DNA inheritance patterns. Here, we assembled mitogenomes six species from the Hymenochaetales order examined 59 2 genetic lineages Phellinus noxius. Gene is largely...

10.1093/gbe/evz181 article EN cc-by-nc Genome Biology and Evolution 2019-08-13

Abstract Background The Fusarium solani species complex (FSSC) comprises fungal pathogens responsible for mortality in a diverse range of animals and plants, but their genome diversity transcriptome responses animal pathogenicity remain to be elucidated. We sequenced, assembled annotated six chromosome-level FSSC clade 3 genomes aquatic plant host origins. established pathosystem investigated the expression data F. falciforme keratoplasticum Chinese softshell turtle ( Pelodiscus sinensis)...

10.1186/s12915-022-01436-7 article EN cc-by BMC Biology 2022-10-20

Influences of impurities on the electron density and transmission a finite HgTe/CdTe quantum well sample are studied numerically in framework Landauer-B\"uttiker formula. In geometry slab with width, electrons helical edge states protected by time-reversal symmetry can tunnel through nonmagnetic at two resonant energy levels. Electrons one side to other quantized conductance be broken down. For small impurity, coefficient even drop zero for crosswalk between sides. The distance is critical...

10.1103/physrevb.88.195149 article EN Physical Review B 2013-11-25

Intrinsic properties of magnetic tunnel junctions (MTJs) are exploited for low-power security electronics. The combination of: 1) fast and nonvolatile storage; 2) stochastic nature subcritical switching; 3) random variation in the anisotropy MTJ make MRAM array ideal implementing physically unclonable function (PUF). We develop two bit-pattern randomization procedures, one which can be exercised at wafer level process line, while other completed in-line tester. procedures generate...

10.1109/ted.2017.2755867 article EN IEEE Transactions on Electron Devices 2017-10-05

We'd built 8kb spin-orbit-torque (SOT) MRAM chips to evaluate our cell design and the process recipes integrate them on CMOS wafer. For SOT cell, switching threshold is well correlated tungsten channel resistivity. We will show design, integration wafers properties array statistics. In this designs, we low current capability for power application good thermal stability.

10.1109/vlsi-tsa51926.2021.9440096 article EN 2021-04-19

The mandarin duck, Aix galericulata, is popular in East Asian cultures and displays exaggerated sexual dimorphism, especially feather traits during breeding seasons. We generated annotated the first duck de novo assembly, which was 1.08 Gb size encoded 16,615 proteins. Using a phylogenomic approach calibrated with fossils molecular divergences, we inferred that last common ancestor of ducks occurred 13.3-26.7 Ma. majority genome repetitive sequences belonged to chicken repeat 1 (CR1)...

10.1093/gbe/evac083 article EN cc-by-nc Genome Biology and Evolution 2022-05-30

A universal MRAM technology is proposed to fulfill versatile applications ranging from quantum computing automotive electronics across a wide operating temperature range of 4K 400K. An ultrathin (1.4 nm) CoFeB composite free layer with an Mg spacer designed enlarge breakdown voltage and write margin, decrease switching current, maintain thermal stability magnetoresistance ratio at all temperatures. High endurance (>10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

10.1109/vlsitechnologyandcir46769.2022.9830503 article EN 2022 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits) 2022-06-12

Brown root rot disease (BRRD), caused by Phellinus noxius, is an important tree in tropical and subtropical areas. To improve chemical control of BRRD deter emergence fungicide resistance P. this study investigated efficacies systemic activities fungicides with different modes action. Fourteen 11 action were tested for inhibitory effects vitro on 39 noxius isolates from Taiwan, Hong Kong, Malaysia, Australia, Pacific Islands. Cyproconazole, epoxiconazole, tebuconazole (Fungicide Resistance...

10.1094/pdis-06-22-1285-re article EN Plant Disease 2022-11-26

Abstract The order Hymenochaetales of white rot fungi contain some the most aggressive wood decayers causing tree deaths around world. Despite their ecological importance and impact diseases they cause, little is known about evolution transmission patterns these pathogens. Here, we sequenced undertook comparative genomics analyses genomes using brown root fungus Phellinus noxius , wood-decomposing lamaensis laminated sulphurascens trunk pathogen Porodaedalea pini . Many gene families...

10.1101/132712 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2017-05-07

The deposition of magnesium on tris(8-hydroxyquinolato) aluminum (Alq3) precovered with thin silver was investigated high resolution synchrotron radiation photoemission. noble-metal deposit first occupies the vicinity pyridyl ring. appearance a Fermi level suggests that incorporated Ag behaves as metallic cluster, consistent results 3d cores, which show nonzero Doniach-Sunjic singularity index 0.061. Upon Mg adsorption Ag∕Alq3 surface, MgAg mixture begins to develop such 4d valence band...

10.1063/1.2511841 article EN Journal of Applied Physics 2007-02-15

We propose an H-shaped two-dimensional topological insulator (2DTI) as a persistent quantum resonance device. The helical edge states of 2DTI are robust against nonmagnetic field. However, the interfere with bound created by impurity. Transmissions between leads shows two kinds in this device, Breit-Wigner and Fano-like resonance. These resonances can be realized device through modulating on-site impurity potential. Resonances because state has no backscattering that is protected...

10.1103/physrevb.93.035405 article EN Physical review. B./Physical review. B 2016-01-05

The zigzag graphene nano-ribbon (ZGNR) has a novel physical property called the quantum spin Hall effect (QSHE). In this paper, we use Landauer method to calculate current and polarization on two types of branching ZGNR (fork-shaped H-shaped). Our results indicate that branch-shape device will enhance polarizing current.

10.1063/1.3684714 article EN Journal of Applied Physics 2012-03-14

Due to the paucity of morphological characters and extensive convergent evolution, bivalve classification is a challenging, two-centuries-old problem (Giribet & Wheeler, 2005; Bieler et al., 2014; Lemer 2016; Giribet Edgecombe, 2020). Consequently, it not surprising that morphology-based phylogenies conflict with sequence-based Tëmkin, 2010; Pearl oysters (superfamily Pterioidea) make critical contributions shellfisheries pearl harvesting. Despite study, their systematic placement...

10.1093/mollus/eyad003 article EN Journal of Molluscan Studies 2023-01-12
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