A5024280902- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Radiomics and Machine Learning in Medical Imaging
- Musculoskeletal synovial abnormalities and treatments
- Lower Extremity Biomechanics and Pathologies
- Advanced X-ray and CT Imaging
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Sports injuries and prevention
- Pulmonary Hypertension Research and Treatments
- Occupational Health and Performance
- Orthopedic Infections and Treatments
- Pelvic and Acetabular Injuries
- Textile materials and evaluations
- Statistical Methods in Clinical Trials
- Sarcoma Diagnosis and Treatment
Cleveland Clinic
2022-2025
Cleveland Clinic Lerner College of Medicine
2022-2024
Background: Elevated body mass index (BMI) is a primary factor contributing to osteoarthritis of the knee, but data are lacking on relationship between BMI and cartilage properties shortly after traumatic injury. Purpose/Hypothesis: The purpose study was relate patellofemoral patellar dislocation, using magnetic resonance imaging–based T1ρ relaxation times assess cartilage. It hypothesized that high correlated with long times, indicating degradation, in both control knees dislocation. Study...
Background: Adolescents who experience a patellar dislocation have an elevated risk of patellofemoral posttraumatic osteoarthritis. Magnetic resonance imaging (MRI)–based T1ρ relaxation times were measured for adolescents to evaluate cartilage after dislocation. Long are indicator degradation. Hypothesis: The primary hypothesis is that will be in the acute phase secondary higher knees with multiple rather than single dislocations due repeated traumatic injury. Study Design: Cross-sectional...
Objective The study was performed to evaluate cartilage within the knee following a first-time patellar dislocation, using elevated MRI-based T1ρ relaxation times as an indicator of low proteoglycan concentration. hypothesis is that for patellofemoral and tibiofemoral are significantly longer knees being treated dislocation than healthy control knees. Design Twenty-one subjects first-time, unilateral patella 16 controls participated in time mapping. Mean were quantified regions injured...
ACL injury is a major risk factor for post-traumatic osteoarthritis (PTOA), however mechanisms are not fully understood. In this work, we use radiomics from quantitative MRI imaging to associate subvisual changes in the infrapatellar fat pad (IPFP) both symptomatic and radiographic PTOA. was collected 113 patients at least 10 years post-ACLR. 1690 11 clinical features were extracted selected using gradient-boosted decision tree classifier model. A subset of texture-associated IPFP no...
The purpose of this study was to evaluate the associations between radiomic features in knee and thigh quantitative MRI with symptomatic radiographic post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction (ACLR). Radiomic cartilage, menisci (extracted from T1ρ maps), muscles anatomic images fat fraction maps) were extracted patient 10+ years ACLR, selected for or PTOA associations. Symptomatic associated medial cartilage compartments, menisci; only.
Motivation: Intramuscular fat is associated with muscle degeneration. Chemical shift-encoded MRI quantifies proton density fraction (PDFF), but multi-site, multi-vendor reproducibility for intramuscular assessment scarcely reported. Goal(s): To evaluate the of a vendor-independent thigh PDFF quantification approach using data and then assess in patients 10 years post-anterior cruciate ligament reconstruction (ACLR). Approach: Phantoms, traveling controls, ACLR were scanned five scanners...
Dixon-based magnetic resonance imaging (MRI) intramuscular proton density fat fraction (PDFF) is a potentially useful biomarker of muscle quality. However, multi-vendor, multi-site reproducibility PDFF quantification, required for large clinical studies, can be strongly dependent on acquisition and processing. The purpose this study was (I) to develop 6-point Dixon MRI-based processing technique reproducible quantification thigh PDFF; (II) evaluate the ability detect differences in status...