A5079022612- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Vitamin D Research Studies
- HIV-related health complications and treatments
- Medicinal Plant Research
- Iron Metabolism and Disorders
- Mycobacterium research and diagnosis
- HIV, Drug Use, Sexual Risk
- Inflammatory Biomarkers in Disease Prognosis
- Vaccine Coverage and Hesitancy
- HIV/AIDS drug development and treatment
- Immune responses and vaccinations
- Child Nutrition and Water Access
- Fungal Infections and Studies
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Peptides and Activities
- Long-Term Effects of COVID-19
- Pregnancy and preeclampsia studies
Padjadjaran University
2014-2025
Dr. Hasan Sadikin General Hospital
2013-2025
Institute of Child Health
2023
University of Indonesia
2023
Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
2023
Murdoch Children's Research Institute
2023
London School of Hygiene & Tropical Medicine
2023
A proportion of tuberculosis (TB) case contacts do not become infected, even when heavily exposed. We studied the innate immune responses TB to understand their role in protection against infection with Mycobacterium tuberculosis, termed "early clearance."Indonesian household cases were tested for interferon-γ release assay (IGRA) conversion between baseline and 14 weeks post recruitment. Blood cell populations ex vivo whole blood cytokine measured at and, a subgroup, flow cytometry was...
Early clearance of Mycobacterium tuberculosis is the eradication infection before an adaptive immune response develops. We aimed to identify host factors associated with early clearance.Indonesian household contacts patients smear-positive (TB) had interferon-γ release assay (IGRA) at baseline and 14 weeks later. was defined as a persistently negative IGRA. Contact characteristics, exposure, disease phenotype were assessed for association positive IGRA each time point.Of 1347 462 TB cases,...
Summary Severe dengue is characterised by thrombocytopenia, plasma leakage and bleeding. Platelets are important for preservation of endothelial integrity. We hypothesised that platelet activation with secondary dysfunction contribute to leakage. In adult Indonesian patients acute dengue, we measured status the response agonist TRAP using flow cytometerbased assays. Patients were monitored daily ultrasonography. Acute was associated an increased expression activated fibrinogen receptor...
Introduction Previous studies, mostly from Africa, have shown that serum cryptococcal antigenemia may precede the development of meningitis and early death among patients with advanced HIV infection. We examined as a risk factor for HIV‐associated mortality in Indonesia, which is experiencing rapidly growing epidemic. Methods included ART‐naïve CD4 cell count below 100 cells/μL no signs an outpatient clinic Bandung, West Java, Indonesia. Baseline clinical data follow‐up were retrieved...
Vitamin D deficiency during pregnancy carries potential threat to fetal well being. Natural conversion of vitamin in the skin can be facilitated by direct ultra violet B (UVB) radiation, but effect is reduced wearing umbrellas, clothes, or sunblock cream. Muslim women wear hijab that allows only face and hands seen. With increasing proportion muslim lack fortification fish consumption Indonesia, it poses a problem for among pregnant women. This study aimed at finding best timing UVB exposure...
Abstract Immunopathology contributes to high mortality in tuberculous meningitis (TBM) but little is known about the blood and cerebrospinal fluid (CSF) immune response. We prospectively characterised response of 160 TBM suspects an Indonesian cohort, including 67 HIV-negative probable or definite cases. patients presented with severe disease 38% died 6 months. Blood from analysed by flow cytometry showed lower αβT γδT cells, NK cells MAIT compared 26 pulmonary tuberculosis (2.4-4-fold, all...
The coronavirus disease 2019 (COVID-19) pandemic has put a great burden on countries as result of the demand for laboratory diagnostic testing severe acute respiratory syndrome 2 (SARS-CoV-2). This paper reports our experiences in rapidly assessing Indonesia's COVID-19 capacity early phase response. Through questionnaire-based survey carried out between 23 March and April, we estimated daily tests that could be done by 44 facilities, excluding national referral laboratory, first assigned to...
Approximately 10-35% of people living with HIV (PLHIV) on antiretroviral therapy (ART) fail to restore CD4+ T cell counts, a state known as immunological non-responder (INR) characterized by persistent immune activation and elevated cytokine levels. Objective: This study aimed identify cytokines that can serve biomarkers for inflammation in INR patients. Methods: We conducted cross-sectional comparing two groups: INRs (PLHIV ART viral suppression) responders (IRs). analyzed 40 samples...
COVID-19 infection in high-risk populations is fatal and has a poor prognosis, necessitating test to determine the protectiveness of immune response. Antibody testing necessary body’s response also vaccination strategies. Among various methods available, chemiluminescent immunoassay (CLIA) more widely used accessible antibody levels. This study aimed protection level S-RBD SARS-CoV-2 IgG using CLIA compared Surrogate Virus Neutralization Test (SVNT). The population this comprised all...
Background and Objectives: The prevalence of stunted children under 5 years in Indonesia is relatively high. Stunting a significant risk factor for wheezing disorders. asthma predictive index (API) identifies with recurrent disorder at developing during the first 3 years. However, its associated factors among has not been studied. This study aims to determine via API score factors. Materials Methods: cross-sectional was conducted Bandung District Health Center from October 2021 January 2022....
Tuberculosis (TB) remains a global public health problem. The determination of tuberculosis infection (TBI) using interferon-gamma release assay has now been used widely. We aim to evaluate the positivity rates Standard E TB-Feron enzyme-linked immunosorbent (TB-Feron ELISA) and F fluorescent immunoassay FIA) their agreement with QuantiFERON-TB Gold Plus (QFT-Plus) among TB high-risk populations in Bandung City, Indonesia. conducted cross-sectional study, including people high risk acquiring...
The elderly population is at high risk of severe complications from influenza due to decreased effectiveness the immune response (Immunosenescence). Trivalent vaccines are designed boost immunity and provide protection against some virus strains. research aims evaluate trivalent vaccine in enhancing populations by examining specific immunological parameters. A total 44 participants were vaccinated with one three vaccines: A/Singapore – EFTHA 1835, EFTHAS 1828, B/Maryland EFTTHAC 1822....
The role of vitamin D in placental functions and fetal growth had been addressed many reports with conflicting results. However, such report is limited for Indonesian population. aim this study was to explore the association between maternal level first trimester biometry later stage pregnancy adjusted OR other determinants like hemoglobin ferritin level.From July 2016 a prospective cohort pregnant women begun four cities West Java, Indonesia. Data on D, ferritin, level, demography were...
Studies had shown that iron-cycling was disturbed by inflammatory process through the role of hepcidin. Pregnancy is characterized shifts interleukin. Our objective to determine if 25(OH) vitamin D (colecalciferol) status associated with ferritin, anemia, and its changes during pregnancy. Method. A cohort study done in 4 cities West Java, Indonesia, beginning July 2016. Subjects were followed up until third trimester. Examinations included maternal colecalciferol, haemoglobin level. Result....
Children with stunted growth have an increased risk of wheezing, and studies shown that low levels vitamin D interleukin (IL)-10, along IL-4 CD23+ expression, are present in asthmatic children. To date, it is not known whether these factors related to the incidence asthma This case-control study investigated association between D, IL-4, IL-10 expression bronchial The included 99 children aged 24-59 months, i.e., 37 stunted-sthmatic (cases), 38 without asthma, 24 non-stunted asthma. All were...
Human herpesviruses (HHVs) are frequently linked to an increased risk of acquiring human immunodeficiency virus (HIV), and vice versa. This study aimed detect herpesvirus (HHV) members in the sera saliva asymptomatic HIV-infected individuals. Paired serum samples were obtained from 30 HHVs detected with a multiplex reverse transcription-polymerase chain reaction (RT-PCR) DNA microarray Clart®Entherpex kit. A total subjects enrolled: 23 (76.67%) men 7 (23.33%) women. The present showed that...
Introduction: Laboratory examination is extremely important in handling the COVID-19 pandemic. In first era of pandemic, molecular and antigen tests were limited. Hence, at that time, it was necessary to carry out antibody Rapid Diagnostic Tests (RDT). However, many RDTs yet obtain Food Drug Authorization (FDA)'s approval. Purpose: Therefore, The Indonesian Association Clinical Pathology Medical (PDS PatKLIn) decided conduct a validity test RDT antibodies find quality SARS-CoV-2 diagnosis...
Indonesia has one of the highest HIV infection rates in Southeast Asia. The use dolutegravir, an integrase strand transfer inhibitor (INSTI), as a first-line treatment underscores need for detailed data on INSTI drug resistance mutations (DRMs). Currently, there is lack comprehensive DRMs and other Indonesian patients, both pre- post-treatment. aim this study was to identify subtypes protease, reverse transcriptase, genes treatment-naive ARV-treated patients Bandung, West Java, Indonesia. A...
Background Interferon gamma release assays (IGRAs) are widely used to determine latent tuberculosis infection status. However, its pregnancy-affected performance and cost-expensive nature warrants for different alternatives pregnant women. This study aims evaluate the diagnostic of several alternative cytokines, including interleukin 2 (IL-2), 10 (IL-10), interferon gamma-induced protein (IP-10) identify status in Materials methods 123 womens were recruited this study. The IGRA was...
In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey understand dynamics of antibody titers. The first serosurvey, which was in June 2021, 1-6 months after Sinovac vaccination, showed median level 41.4 BAU/mL (interquartile range (IQR): 10-629.4 BAU/mL). one month (August 2021) Moderna vaccine and 4000 (IQR: 3081-4000 last year 2022) 4000-4000 this survey, only 39 (11.9%) had levels below maximum BAU/mL. Thus, dose,...