Subacute poisoning of 1,2-dichloroethane (1,2-DCE) has become a serious occupational problem in China, and brain edema is its main pathological consequence, but little known about the underlying mechanisms. As metabolite 1,2-DCE, 2-chloroethanol (2-CE) more reactive, might play an important role toxic effects 1,2-DCE. In our previous studies, we found that matrix metalloproteinases-9 (MMP-9) expression was enhanced mouse brains upon treatment with rat astrocytes exposed to 2-CE. present...

Saposhnikovia divaricata is an important economic medicinal plant in eastern Asia. It the National Grade III Key Protected Wild Medicinal Plants China. However, little known about effects of projected climate change on its adaptability and future distribution. In this study, we simulated suitable area S. under current (1970–2000) four scenarios (i.e., SSP1-2.6, SSP2-4.5, SSP3-7.0 SSP5-8.5) 2050s (2041–2060), 2070s (2061–2080) 2090s (2081–2100) using maximum entropy model (MaxEnt). The...

Plaque accumulation and microbial community changes are important causes of periodontal disease. Cleaned plaque microorganisms will reattach to form biofilms, but the recovery outcome communities in different health states remain unknown. In this study, we tracked biofilm remodeling process 206 dental samples from 40 healthy periodontal, gingivitis periodontitis volunteers at 6 time points before after supragingival scaling. We found that changed asynchronously during process, more severe...

The maturation of magnetic cell separation technology places increasing demands on performance. While a number factors can cause sub-optimal performance, one the major challenges be non-specific binding nano- or microparticles to non-targeted cells. Depending type separation, this have negative effect final purity, recovery targeted cells, both. In work, we quantitatively demonstrate that nanoparticles impart magnetization cells such these retained in column and thus negatively impact purity...

Superoxide dismutase (SOD) proteins, as one kind of the antioxidant enzymes, play critical roles in plant response to various environment stresses. Even though its functions oxidative stress were very well characterized, SOD family genes regulating alkaline are not fully reported.We identified potential members by using Hidden Markov model and soybean genome database. The neighbor-joining phylogenetic tree exon-intron structures generated software MEGA 5.0 GSDS online server, respectively....

Strigolactones (SLs) are the major plant hormones that play important roles in regulating organ development and environmental stress tolerance plants. Even though SL-related genes have been identified well characterized some plants, information of soybean is not fully established yet, especially response to salt alkaline stresses. In this study, we nine SL biosynthetic include two D27, CCD7, CCD8, three MAX1, as seven signaling comprised D14, MAX2, D53 genome. We found evolutionary conserved...

Abstract The June‐July Yangtze flooding in 1998 and 2020 drew incredible attention owing to the extreme precipitation events devastating societal/economic damages. However, quantitative estimation of moisture transport mechanism is intensely discussed but still unresolved. Here we investigated two from a unique perspective Eulerian atmospheric water tracers that tries explain model physics. results showed supplies Northwest Pacific decreased despite different inducements, whereas southwest...

Magnetic separation in biomedical applications is based on differential magnetophoretic mobility (MM) of microparticulate matter viscous media. Typically, the difference MM obtained by selectively labeling target cells with superparamagnetic iron oxide nanoparticles (SPIONs). We have measured monodisperse, polystyrene microspheres (PSMs), and without attached SPIONs as a model cell motion induced nanoparticle magnetization, using variable H field tracking velocimetry (CTV). As paramagnetic...

The magnetic characteristics of hemoglobin (Hb) changes with the binding dioxygen (O

Neospora caninum, an obligate intracellular protozoan parasite, can infect a large variety of vertebrate hosts including the most economically important cattle. Infection with N. caninum is main cause abortion in both dairy and beef cattle, which causes great economic losses worldwide. However, mechanism host cell infection by has not been fully elucidated, especially terms inflammatory responses. In this study, effect TLR-ERK signaling pathway on synthesis pro-inflammatory interleukin-12p40...

Using novel media formulations, it has been demonstrated that human placenta and umbilical cord blood-derived CD34+ cells can be expanded differentiated into erythroid with high efficiency. However, obtaining mature functional erythrocytes from the immature cell cultures purity in an efficient manner remains a significant challenge. A distinguishing feature of reticulocyte maturing erythrocyte is increasing concentration hemoglobin decreasing volume results increased magnetophoretic mobility...

The plant hormone strigolactones (SLs) play crucial roles in regulating development and adaptations to abiotic stresses. Even though the functional of SLs have been identified response stresses, function, mechanism are not fully established under alkaline stress. In this study, we that exogenous SL could improve tolerance soybean seedlings, especially when treated with 0.5 μM SL. application remarkably reduced malondialdehyde content, hydrogen peroxide increased activity antioxidant enzymes...

NDR1/HIN1-like (NHL) family genes are known to be involved in pathogen induced plant responses biotic stress. Even though the NHL have been identified and characterized defense some plants, roles of these associated with abiotic stress tolerance wild soybean is not fully established yet, especially response alkaline stress.We potential by using Hidden Markov model genome. The maximum-likelihood phylogenetic tree conserved motifs were generated MEME online server MEGA 7.0 software,...

The Apicomplexan parasite Neospora caninum, an obligate intracellular protozoan, causes serious diseases in a number of mammalian species, especially cattle. Infection with N. caninum is associated abortions both dairy and beef cattle worldwide which have major economic impact on the industry. However, mechanism by proliferates within host cells poorly understood. Epidermal growth factor receptor (EGFR) protein kinase ubiquitously expressed, present cell surfaces numerous has been confirmed...

Abstract Recent studies have demonstrated the crucial role of Cytochrome P450 enzymes (CYPs) in production secondary metabolites, phytohormones and antioxidants plants. However, their functional characterization specifically under alkaline stress remains elusive. CYP82C4 was key gene screened from a family wild soybean CYPs our previous studies. The aim this present study to clone Glycine soja GsCYP82C4 characterize its functions Arabidopsis max. results showed that displayed high expression...