A5022420344- Colorectal Cancer Screening and Detection
- Acute Kidney Injury Research
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Genetic factors in colorectal cancer
- Sepsis Diagnosis and Treatment
- Medical Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Cardiac Arrest and Resuscitation
- Chronic Kidney Disease and Diabetes
- Gastrointestinal motility and disorders
- Viral-associated cancers and disorders
- Esophageal and GI Pathology
- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Cardiac, Anesthesia and Surgical Outcomes
Zunyi Medical University
2025
Chongqing University
2022-2025
Chongqing Emergency Medical Center
2025
Beijing Chao-Yang Hospital
2018-2024
Capital Medical University
2019-2024
Sichuan University
2014-2024
Air Force Medical University
2024
Kunming Medical University
2024
West China Hospital of Sichuan University
2014-2024
Chongqing Medical University
2023-2024
We describe the design, synthesis and application of a sensitive, selective, fast fluorescent probe for H2S detection. A linear relationship between emission intensity sulfide concentration was observed in biological bovine plasma systems. With this probe, we were able to estimate mouse blood brain tissues.
Vitamin D<sub>3</sub> is critical for the regulation of calcium and phosphate homeostasis. In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepileptic drugs antimicrobial agent rifampin, resulting in drug-induced osteomalacia, which attributed to vitamin D deficiency. We now report a novel CYP3A4-dependent pathway, 4-hydroxylation 25-hydroxyvitamin (25OHD<sub>3</sub>), induction may contribute The metabolism 25OHD<sub>3</sub> was fully...
CD44 is a multifunctional transmembrane protein involved in cell proliferation, angiogenesis, invasion, and metastasis. identified as cancer stem marker, the CD44-positive breast cells are enriched residual populations after conventional therapies, suggesting that may be an important target for prevention therapy. Therefore, we investigated inhibitory effect of novel Gemini vitamin D analog,...
This study aimed to investigate the potential association between white blood cell counts and risk of lung cancer, including its subtypes, through Mendelian randomization (MR) analysis. We conducted a two-sample MR analysis using genome-wide (GWAS) summary statistics for both exposure traits (eosinophil count, neutrophil lymphocyte monocyte basophil total count) outcome (lung cancer subtypes). The GWAS dataset included 29,266 cases (11273 adenocarcinoma (LUAD), 7426 squamous carcinoma...
Small intestinal bacterial overgrowth (SIBO) has been associated with anatomical and motility-related abnormalities. Specifically, obesity postulated to alter small bowel motility, leading SIBO.(i) Assess the prevalence of SIBO in obesity; (ii) determine relationship SIBO, using transit time (SBTT) pH; (iii) profile gut microbiome obese non-obese patients SIBO.Thirty consecutive participants referred for underwent lactulose breath tests (LBTs) wireless motility capsule (WMC) studies....
Abstract Background Acute kidney injury (AKI) newly-emerged in intensive care unit (ICU), has not been thoroughly studied previous researches, is likely to differ from AKI developed before ICU admission. This study aimed evaluate the incidence, risk factors, clinical features and outcome of new-onset critically ill patients. Methods The data present derived a multicenter, prospective cohort in17 Chinese ICUs (January 2014 - August 2015). survival analysis were assessed. Results A total 3374...
The lack of early renal function recovery among geriatric patients with acute kidney injury (AKI) in the intensive care unit (ICU) is a commonly observed and acknowledged poor prognostic factor, especially for older adults. However, no reliable biomarker available identifying individuals at risk non-recovery or mortality In this prospective observational cohort study, we enrolled critically ill adults (aged ≥ 60 years) AKI from ICU followed their disease progression. primary endpoint was...
Abstract Numerous preclinical, epidemiologic, and clinical studies have suggested the benefits of vitamin D its analogues for prevention treatment cancer. However, hypercalcemic effects limited use 1α,25(OH)2D3, hormonally active form D. To identify with better efficacy low toxicity, we tested &gt;60 novel Gemini a unique structure two side chains growth inhibition breast cancer cells. Our initial found that some are 5–15 times more than 1α,25(OH)2D3 in assay. In vivo experiments were...
Commensal microbiota dysbiosis is associated with the development of lung cancer. The current studies about composition respiratory in cancer patients yielded inconsistent results. This study aimed to examine association between airway and clinicopathological characteristics.Surgically removed lesion tissues from 75 non-small cell 7 benign pulmonary diseases were analyzed by 16S rRNA sequencing. Taxonomy, relative abundance, diversity compared among different pathology TNM stages. effects...
Acute kidney injury (AKI) is a common disease in the intensive care unit (ICU). AKI patients with nonrecovery of renal function have markedly increased risk death compared recovery. The current study aimed to explore and validate utility urinary cell cycle arrest biomarkers for predicting who developed after ICU admission.We prospectively consecutively enrolled 379 critically ill admission ICU, which were divided into derivation cohort (194 patients) validation (185 patients). tissue...
Both sepsis and AKI are diseases of major concern in intensive care unit (ICU). This study aimed to evaluate the excess mortality attributable for acute kidney injury (AKI).A propensity score-matched analysis on a multicenter prospective cohort 18 Chinese ICUs was performed. Propensity score sequentially conducted match patients with without day 1, 2, 3-5. The primary outcome hospital death patients.A total 2008 (40.9%) were eligible study. Of 1010 sepsis, 619 (61.3%) matched whom did not...
Abstract Objective Chest drainage is a standard procedure in thoracoscopic surgery for lung cancer. However, chest tube placement may deteriorate the ventilation capacity and increase difficulty of postoperative management patients. The study investigated on effects enhanced recovery after (ERAS) program focusing surgical cancer Methods population consisted 60 patients undergoing video-assisted (VATS) implementation ERAS another group VATS before program. Results mean time first food intake...
Purpose: Sepsis-associated acute kidney injury (S-AKI) contributes to high mortality, but it is lack of specific treatments. We aimed investigate the underlying mechanism S-AKI and identify target drugs alleviate AKI. Methods: establish a stable mouse model by Pseudomonas aeruginosa incision infection. Based on high-throughput sequencing bioinformatics analysis, we investigated selected drug (VX-702) for S-AKI. An in vitro established co-cultured tubular epithelial cell line (TCMK-1) cells...
Antifungal therapy is a common treatment option for pulmonary aspergillosis, but its use to prevent recurrence and relieve symptoms in patients with aspergillosis remains controversial. This study aimed explore the short-term efficacy cost of itraconazole vs. voriconazole during perioperative period. We retrospectively collected clinical data 55 who underwent surgery received or as antifungal between January 1, 2016, October 31, 2022, at Department Thoracic Surgery, Affiliated Hospital Zunyi...