A5019497069- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Gastrointestinal motility and disorders
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Abdominal Surgery and Complications
- Gastrointestinal disorders and treatments
- Intestinal and Peritoneal Adhesions
- Adenosine and Purinergic Signaling
- Body Contouring and Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Peptidase Inhibition and Analysis
- Respiratory and Cough-Related Research
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Phonocardiography and Auscultation Techniques
Feinstein Institute for Medical Research
2014-2024
Northwell Health
2015-2024
Cold Spring Harbor Laboratory
2023-2024
Long Island Jewish Medical Center
2018-2019
Hofstra University
2012-2018
Temple University
2007-2012
Temple University Hospital
2006-2011
Immunovaccine (Canada)
2010
Hy-Line (United States)
2009
Small intestinal bacterial overgrowth (SIBO) has been associated with anatomical and motility-related abnormalities. Specifically, obesity postulated to alter small bowel motility, leading SIBO.(i) Assess the prevalence of SIBO in obesity; (ii) determine relationship SIBO, using transit time (SBTT) pH; (iii) profile gut microbiome obese non-obese patients SIBO.Thirty consecutive participants referred for underwent lactulose breath tests (LBTs) wireless motility capsule (WMC) studies....
It was recently shown that the tonic pressure contribution to high-pressure zone of oesophago-gastric segment (OGS) contains contributions from three distinct components, two which are smooth muscle intrinsic sphincter a proximal and distal component [J Physiol 2007; 580.3: 961]. The aim this study compare sphincteric components in normal subjects with those gastro-oesophageal reflux disease (GORD) patients. A simultaneous endoluminal ultrasound manometry catheter pulled through OGS 15...
Background and study aims After stone removal in endoscopic retrograde cholangiopancreatography (ERCP), an occlusion cholangiogram (OC) is performed to confirm bile duct clearance. OC can miss residual stones that lead recurrent biliary symptoms. The aim of this was assess if digital peroral cholangioscopy (POC) increased the diagnostic yield are missed with OC. Patients methods having ERCP for choledocholithiasis were enrolled into only they had one following criteria: dilated ≥ 12 mm...
The following discussion of the esophagogastric junctions includes commentaries on three component structures sphincteric segment between stomach and esophagus; pressure contributions from components in normal subjects gastroesophageal reflux (GERD) patients; mechanism action endoscopic plication to determine underlying pathophysiology GERD; vitro muscle strip studies defects within potentially leading GERD.
AIM:To study the angle between circular smooth muscle (CSM) and longitudinal (LSM) fibers in distal esophagus. METHODS:In order to identify possible mechanisms for greater shortening compared proximal esophagus during peristalsis, angles LSM CSM layers were measured 9 cadavers.The outer layer of muscularis propria was exposed after stripping serosa.The inner then revealed dissection esophageal mucosa underlying mucosa.Photographs each specimen taken with half open folded back showing both...
Dysregulated transforming growth factor-beta (TGF-β) signaling contributes to fibrotic liver disease and hepatocellular cancer (HCC), both of which are associated with fatty disease. SIRT6 limits fibrosis by inhibiting TGF-β through deacetylating SMAD2 SMAD3 lipogenesis SREBP1 SREBP2 activity. Here, we showed that, compared wild-type mice, high-fat diet-induced is worse in signaling-deficient mice (SPTBN1+/−) the mutant had reduced abundance liver. Therefore, hypothesized that altered...
Abstract Background We sought to determine how the individual components of distal esophagus and proximal stomach form gastroesophageal junction high‐pressure zone (GEJHPZ) antireflux barrier. Methods An endoscopic ultrasound/manometry catheter was pulled through in 20 normal subjects. The axial length width structures on ultrasound were measured. anatomic orientation (GEJ) examined two organ donor specimens using micro‐computed tomography (micro‐CT). Key Results three distinct identified...
Relaxation of gastric clasp and sling muscle fibers is involved the transient lower esophageal sphincter relaxations underlying pathophysiology gastroesophageal reflux disease (GERD). These do not contribute tone to high-pressure zone in GERD patients, indicating their role pathophysiology. This study identifies some mediators nicotine-induced relaxation muscarinic receptor precontracted fibers. Muscle strips from organ donors with bethanechol were relaxed nicotine then rechallenged after...
Although muscarinic receptors are known to mediate tonic contraction of human gastrointestinal tract smooth muscle, the receptor subtypes that contractions not entirely clear. Whole stomachs with attached esophagus were procured from organ transplant donors. Cholinergic contractile responses clasp, sling, lower esophageal circular (LEC), midesophageal (MEC), and longitudinal (MEL) muscle strips determined. Sling fibers contracted greater than other fibers. Total, M<sub>2</sub> M<sub>3</sub>...
Afferent and efferent fibers in the vagus nerve travel inside fascicles form branches to innervate organs regulate organ functions. The spatial organization of fascicles, with respect functions they mediate innervate, is unknown. Accordingly, it unknown whether such can be leveraged by bioelectronic devices for function- organ-specific neurostimulation. To characterize functional microscopic anatomy nerve, we developed a pipeline consisting micro-computed tomography 3D reconstruction...
To compare the gastroesophageal junction of human with pig, M 2 and 3 receptor densities potencies muscarinic subtype selective antagonists were determined in gastric clasp sling smooth muscle fibers. Total receptors are higher pig than compared fibers but lower Clasp have fewer both humans pigs. Similar to fibers, contract significantly less Analysis methoctramine Schild plot suggests that involved mediating contraction Darifenacin potency mediate Taken together, data suggest similar
Abstract Background Proper function of the gastro‐esophageal high pressure zone is essential for integrity antireflux barrier. Mechanisms include tonic contractions and decreased tone during transient lower esophageal sphincter relaxations. Methods We characterized pharmacology nicotinic receptors mediating relaxations human upper gastric (clasp sling fibers) using currently available subtype selective antagonists in tissue from organ transplant donors. Donors with either a history reflux...
Purpose . To determine intragastric pressure threshold for inducing gastroesophageal junction (GEJ) opening in normal control subjects with and without hiatal hernia, patients reflux disease. Methods This study was performed 13 volunteers, 5 volunteers 3 During endoscopy a transducer used to measure baseline gastric pressures. The the stomach measured while air insufflated into until opened on endoscopic view. Results There were two patterns of GEJ volunteers. mean Gastroesophageal...
Volumetric laser endomicroscopy (VLE) is an advanced imaging modality used in Barrett's oesophagus (BE) to help identify dysplasia the oesophagus. VLE criteria exist for oesophageal but not gastric cardia. The aim of this study was determine if there are vivo features that can predict cardia BE.This a single-centre observational cohort from August 2016 2018. Patients were included they had BE, undergoing exam as standard care, and suspicious target marked at following correlated histology...