A5069170920- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Veterinary medicine and infectious diseases
- Chemical Reactions and Isotopes
- Gastric Cancer Management and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Digestive system and related health
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Respiratory and Cough-Related Research
- Microscopic Colitis
- Esophageal Cancer Research and Treatment
- Galectins and Cancer Biology
- Potassium and Related Disorders
V.I. Vernadsky Crimean Federal University
2017-2025
Research Institute of Agriculture of Crimea
2023-2024
Carol Davila University of Medicine and Pharmacy
2020
Daegu Catholic University Medical Center
2020
Slovak Medical University
2020
Military Medical Academy
2020
The article discusses the relationship between autoimmune gastritis and Helicobacter pylori (H. pylori) infection. prevailing point of view in literature is that Hpylori infection can act as a trigger factor, contributing to development progression due phenomenon antigen mimicry. At same time, there are publications on protective effect H. relation occurrence absence link these diseases. Recent data indicate presence patients with contributes atrophic changes mucous membrane an increased...
The presented article discusses the risk factors for occurrence of large and giant gastric ulcers (in particular, use immunosupressants, nonsteroidal anti-inflammatory drugs, infectious etiology), need differential diagnosis between benign infiltrative ulcerative form cancer, as well its other tumor lesions), features course such (tendency to bleeding, perforation, penetration).
Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, large cohorts not available to understand their efficiency and safety. Therefore, our aims were evaluate the association between administration of ASDs, outcome AP, frequency gastrointestinal (GI) bleeding GI infection patients with AP. We initiated an international survey performed retrospective data analysis on AP hospitalized January 2013 December 2018. Data 17,422 adult collected from 59 centers 23...
Patients with gastroesophageal reflux disease (GERD) are routinely prescribed one of the six FDA approved proton pump inhibitors (PPI). All these PPI CYP2C19 enzyme to varying degrees. The phenotype pantoprazole-13C breath test (Ptz-BT) was used identify patients who poor metabolizers (PM) and extent phenoconversion activity caused by four (omeprazole, esomprazole pantoprazole rabeprazole) in 54 newly diagnosed GERD prior initiating randomly selected therapy 30 d after therapy.
Aim: to evaluate the efficacy and safety of new prokinetic drug acotiamide in treatment functional dyspepsia. Key findings. Acotiamide is an antagonist inhibitory muscarinic receptors type 1 2 a reversible inhibitor acetylcholinesterase activity. In patients with dyspepsia normalizes accommodation fundal part stomach accelerates delayed gastric emptying. The conducted studies have confirmed higher compared placebo reducing severity such symptoms as feeling epigastric postprandial fullness...
Was investigated genetic polymorphism of cytochrome P450 2C19 and studied its effect on out- come PPIs therapy in 136 patients the Crimean population suffering from gastroesophageal reflux disease. Patients were divided into three groups: those with erosive esophagitis - 49, non-erosive disease 60, hypersensitivity 27. It was found that sample introduced *1/*1 *1/*2 genotypes. Carriage genotypes are equally common among male female. genotype more likely to occur a complete response therapy,...
The article discusses the statements of section consensus meeting “Maastricht-VI” (2021), dedicated to role H.pylori infection eradication in prevention development gastric cancer. Experts have confi rmed that this is currently main etiological factor Its leads regression atrophic changes mucosa and reduces risk This makes it necessary implement population program “test treat” for purpose cancer include among priorities healthcare.
Aim : to present the main statements of Kyoto International Consensus report on anatomy, pathophysiology, and clinical significance gastroesophageal junction. Key points. The experts reviewed adopted 28 concerning (1) definition junction (GEJ); (2) GEJ zone, covering area located 1 cm proximal distal in relation junction; (3) assessment chemical bacterial (Helicobacter pylori) factors leading development inflammation, metaplasia neoplasia mucosa GEJ; (4) a new Barrett’s esophagus. Conclusion...
To determine the factors that affect effectiveness of gastroesophageal reflux disease therapy, a correlation analysis was performed included international GERD questionnaire, hospital anxiety and depression score (HADS), data on polymorphism cytochrome P450 2C19 in 136 patients with different variants (GERD): esophagitis (RE), non-erosive (NERD) hypersensitivity (RH). The presence strong negative relationship between favorable outcome PPI therapy demonstrated after 4 weeks RE, NERD RH groups...
The article discusses various measures that may be taken to increase the effectiveness of eradication Helicobacter pylori, taking into account growing resistance this infection antibiotics. These include: refusal use standard triple therapy in an isolated form, 14-day duration course eradication, inclusion bismuth preparations combination with antibiotics schemes therapy, preference for appointment proton pump inhibitors such as rabeprazole and esomeprazole (in double dose, if necessary),...
Modern approaches to the diagnostics and treatment of one most common forms functional bowel disorders, diarrhea (FD), are discussed in article. The clinical features FD considered. It is emphasized that various organic diseases (inflammatory diseases, microscopic colitis, celiac disease, lactase defi ciency, etc.) can occur under mask FD, which makes diagnosis a "diagnosis exclusion" involves thorough laboratory instrumental examination patients. main drugs used for PD characterized.