A5100678780- Robotic Path Planning Algorithms
- Reinforcement Learning in Robotics
- MicroRNA in disease regulation
- Evolutionary Algorithms and Applications
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Neuropeptides and Animal Physiology
- AI-based Problem Solving and Planning
- Constraint Satisfaction and Optimization
- Robot Manipulation and Learning
- Robotics and Sensor-Based Localization
- Diabetes and associated disorders
- Regulation of Appetite and Obesity
- Data Management and Algorithms
- Optimization and Search Problems
- Antibiotic Use and Resistance
- Molecular Biology Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Sports and Physical Education Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Congenital heart defects research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Maritime Navigation and Safety
- Fish Biology and Ecology Studies
- Guidance and Control Systems
Universidade de Santiago de Compostela
2010-2022
Midatech Pharma (United Kingdom)
2022
Complejo Hospitalario de Jaén
2021
University of Almería
2015
Universidad de Huelva
2010
Carbapenem-resistant Gram-negative bacilli (CR-GNB) are among the most threatening microorganisms worldwide and carbapenem use facilitates their spread. Antimicrobial stewardship programmes (ASPs) can help to optimize of antibiotics. This study evaluates impact a multifaceted educational ASP on epidemiology CR-GNB.We conducted quasi-experimental, time-series in seven hospitals, from January 2014 September 2018. The key intervention was composed interviews promoting appropriate carbapenems....
Radial glial cells (RGCs) are the first cell populations of nature to appear during brain ontogeny. They act as primary progenitor (stem) well a scaffold for neuronal migration. The proliferative capacity these cells, both in development and adulthood, has been subject interest past decades. In contrast with mammals where RGCs restricted specific ventricular areas adult brain, predominant element fishes. However, developmental studies on cartilaginous fishes scant. We have studied expression...
The dorsal part of the developing telencephalon is one brain areas that has suffered most drastic changes throughout vertebrate evolution. Its evolutionary increase in complexity was thought to be partly achieved by appearance a new neurogenic niche embryonic subventricular zone (SVZ). Here, kind amplifying progenitors (basal progenitors) expressing Tbr2, undergo second round divisions, which believed have contributed expansion neocortex. Accordingly, existence pallial SVZ been classically...
Neurogenesis is a multistep process by which progenitor cells become terminally differentiated neurons. Adult neurogenesis has gathered increasing interest with the aim of developing new cell-based treatments for neurodegenerative diseases in humans. Active sites adult exist from fish to mammals, although mammalian brain number and extension neurogenic areas considerably reduced comparison non-mammalian vertebrates they mostly telencephalon. Much our understanding this field based studies on...
Abstract The development of galanin‐like immunoreactive (GAL‐ir) cells and fibers was investigated in the brain brown trout embryos, alevins, juveniles, adults (some spontaneously releasing their gametes). earliest GAL‐ir neurons appeared preoptic region primordial hypothalamic lobe 12‐mm embryos. After hatching, new lateral, anterior, posterior tuberal nuclei, late area postrema. In further populations nucleus subglomerulosus magnocellular nucleus. neuronal groups present juveniles were...
Cyclic arginyl-glycyl-aspartic acid peptide (cRGD) peptides show a high affinity towards αVβ3 integrin, receptor overexpressed in many cancers. We aimed to combine the versatility of ultrasmall gold nanoparticles (usGNP) with target selectivity cRGD for directed delivery cytotoxic payload novel design. usGNPs were synthesized modified Brust-Schiffrin method and functionalized via amide coupling ligand exchange their uptake, intracellular trafficking, toxicity characterized. Our demonstrated...
During development of the olfactory bulb (OB), glial cells play key roles in axonal guiding/targeting, glomerular formation and synaptic plasticity. Studies mammals have shown that radial peripheral glia (olfactory ensheathing cells, OECs) are involved OB. Most studies about OB were carried out mammals, but data lacking most non-mammalian vertebrates. In present work, we studied system cartilaginous fish Scyliorhinus canicula (catshark) using antibodies against markers, such as fibrillary...
Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells by immune system, and CD8+ T lymphocytes are critical actors in this autoimmune response. Pancreatic islets surrounded a mesh nervous cells, peri-insular Schwann which also targeted autoreactive express specific antigens, such as neurotrophic factor S100-β. Previous work has shown increased proliferative responses to whole S100-β both human T1D patients nonobese diabetic (NOD) mouse model. We describe for first time...
Usually, real-world problems involve the optimization of multiple, possibly conflicting, objectives. These may be addressed by Multi-objective Reinforcement learning (MORL) techniques. MORL is a generalization standard Learning (RL) where single reward signal extended to multiple signals, in particular, one for each objective. process policies that optimize objectives simultaneously. In these problems, use directional/gradient information can useful guide exploration better and behaviors....
In mammals, the development of olfactory bulb (OB) relies in part on expression transcription factors involved specifications/differentiation glutamatergic cells. a previous study from our group, high molecular similarity was reported between mammals and cartilaginous fishes regarding neurogenic mechanisms underlying cells telencephalon. However, information about transcriptional program operating system (mainly represented by mitral cells) OB is lacking catshark Scyliorhinus canicula, fish....
In this paper, we propose the multivariable fuzzy temporal profile model (MFTP), which enables projection of expert knowledge on a physical system over computable description. This description may be used to perform automatic abstraction set parameters that represent evolution system. is based constraint satisfaction problem (CSP) formalism, an explicit representation knowledge, and theory, from it inherits ability imprecision uncertainty are characteristics human vagueness. We also present...