A5018536388- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Genetic Associations and Epidemiology
- IL-33, ST2, and ILC Pathways
- Health disparities and outcomes
- Air Quality Monitoring and Forecasting
- Healthcare Policy and Management
- Gene expression and cancer classification
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Food Security and Health in Diverse Populations
- COVID-19 and healthcare impacts
- Genetics, Bioinformatics, and Biomedical Research
- Noise Effects and Management
- Respiratory Support and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoparticles: synthesis and applications
- Climate Change and Health Impacts
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Pharmaceutical studies and practices
- Infection Control and Ventilation
- Inflammatory Myopathies and Dermatomyositis
- Biomedical and Engineering Education
Pennsylvania State University
2024-2025
Penn State Milton S. Hershey Medical Center
2025
University of Pennsylvania
2018-2023
Misgav Ladach
2022
Universidad de Salamanca
2022
The coronavirus disease 2019 (COVID-19) pandemic caused dramatic changes in daily routines and health care utilization delivery patterns the United States. Understanding influence of these associated public interventions on asthma is important to determine effects patient outcomes identify measures that will ensure optimal future delivery.We sought pediatric asthma-related utilization, respiratory viral testing, air pollution during COVID-19 pandemic.For time period January 17 May 17, 2015...
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated validated gene expression prediction models for the purpose transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP which 399 were prioritised as contributors to regulation. Imputation proteome microRNAome uncovered 97 renal proteins 11 miRNAs BP. Integration plasma...
Respiratory viruses, air pollutants, and aeroallergens are all implicated in worsening pediatric asthma symptoms, but their relative contributions to exacerbations poorly understood. A significant decrease has been observed during the coronavirus disease 2019 pandemic, providing a unique opportunity study how major triggers correlate with activity.To determine whether changes respiratory and/or pandemic were concomitant decreased exacerbations.Health care utilization viral testing data...
Autoimmune diseases often exhibit a preclinical stage before diagnosis. Electronic health record (EHR) based-biobanks contain genetic data and diagnostic information, which can identify individuals at risk for progression. Biobanks typically have small numbers of cases, are not sufficient to construct accurate polygenic scores (PRS). Importantly, progression case-control phenotypes may shared basis, we exploit improve prediction accuracy. We propose novel method Genetic Progression Score...
CCAAT/Enhancer Binding Protein D (CEBPD), a pleiotropic glucocorticoid-responsive transcription factor, modulates inflammatory responses. Of relevance to asthma, expression of CEBPD in airway smooth muscle (ASM) increases with glucocorticoid exposure. We sought characterize CEBPD-mediated transcriptomic responses exposure ASM by measuring changes observed after knockdown and its impact on asthma-related function. Primary cells derived from four donors were transfected or non-targeting (NT)...
Abstract Motivation In the post genome-wide association study (GWAS) era, omics techniques have characterized information beyond genomic variants to include cell and tissue type-specific gene transcription, transcription factor binding sites, expression quantitative trait loci (eQTL) many other biological layers. Analysis of data its integration has in turn improved functional interpretation disease-associated genetic variants. Over 170 000 transcriptomic epigenomic datasets corresponding...
Alveolar type 2 epithelial (AT2) cells are a key progenitor population critical to lung homeostasis whose dysfunction is implicated in pulmonary fibrosis (PF) pathogenesis. In proof of concept study utilizing murine model with inducible expression PF related missense mutation 218T>C (= Ile->Thr at position 73 [I73T]) the Surfactant Protein C [SP-C] gene we showed that proSP-C<sup>I73T</sup> was sufficient cause early injury and late fibrotic remodeling. this study, RNA-Seq profiling...
Rationale: Cigarette smoking has been associated with worse COVID-19 outcomes, while inhaled corticosteroids (ICS) use may be protective against COVID-19. Previous studies have suggested that gene expression levels of key cellular mediators SARS-CoV-2 infectivity, such as ACE2 and TMPRSS2, are increased in response to cigarette exposure decreased glucocorticoids. We sought determine whether the entry factor genes ACE2, TMPRSS2 FURIN had changed according publicly available cigarette-,...
Rationale: The COVID-19 pandemic dramatically changed daily routines as well healthcare utilization and delivery patterns in the United States. We sought to identify changes pediatric asthma-related levels of air pollution i.e. particulate matter (PM2.5, PM10) gaseous chemicals (NO2, O3) during Philadelphia. hypothesized that declining asthma care early stages rebounded after relaxation COVID-19-related public health measures. Methods: For time period Mar 17 Dec years 2015-2020,...
Rationale: Inhaled corticosteroids (ICS) exert anti-inflammatory effects via modulation of gene transcription following their binding to glucocorticoid receptor (GR) factors.The largest ICS response genome-wide association study (GWAS) date, based on 2672 subjects from GSK clinical trials fluticasone furoate and propionate, found little evidence that common genetic variants underlie differences in lung function observed after 8-12 weeks use.Given some the nominally significant loci this GWAS...