A5055401573- Advanced Neuroimaging Techniques and Applications
- Radiation Dose and Imaging
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Peripheral Neuropathies and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Virus-based gene therapy research
- Advanced X-ray and CT Imaging
- Cerebral Venous Sinus Thrombosis
- Parkinson's Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Lysosomal Storage Disorders Research
- Craniofacial Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Radiomics and Machine Learning in Medical Imaging
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
- Hematological disorders and diagnostics
University of Florida
2017-2025
Florida College
2019-2024
University of Florida Health
2023
Texas Medical Association
2022
Columbia University Irving Medical Center
2022
Research Institute of Radiology
2016-2018
Brigham and Women's Hospital
2014-2016
Medical College of Wisconsin
2014-2015
The Bronx Defenders
2015
Harvard University
2014
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available human studies. Here we show dural structures along the venous sinuses dorsal regions and cranial nerves ventral brain. 3D T2-Fluid Attenuated Inversion Recovery magnetic resonance imaging relies on internal signals of protein rich fluid rather than contrast media used present study to visualize major structures. Moreover detect direct connections between channels vascular cervical...
A first-in-human trial of diaphragmatic gene therapy (AAV1-CMV-GAA) to treat respiratory and neural dysfunction in early-onset Pompe disease was conducted. The primary objective this study assess the safety rAAV1-CMV-hGAA vector delivered diaphragm muscle subjects with ventilatory insufficiency. Safety assessed by measurement change serum chemistries hematology, urinalysis, immune response GAA AAV, as well level health. data demonstrate that AAV treatment safe there were no adverse events...
Purpose: The purpose of this work was to evaluate the image quality a commercial CT scanner equipped with novel detector and filtration technology called PureVision Optics (PVO). Methods: number, noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF), noise power spectrum (NPS) were assessed using ACR Accreditation phantom scanned various acquisitions at 80 kV, 100 120 135 each multiple CTDI vol values 20 mGy, 40 65 mGy. Artifacts evaluated in an anthropomorphic head...
Pituitary consequences of chronic head trauma in boxing have not been investigated detail.To investigate the pituitary function retired or active amateur boxers.Cross-sectional, observational study.Turkey.61 actively competing (n = 44) 17) male boxers Turkish National Boxing Team.Body composition variables, volume (in 38 61 boxers), and function.9 (15%) had growth hormone (GH) deficiency 5 (8%) adrenocorticotropic deficiency. All with GH except 1 were from boxing. Of 17 boxers, 8 (47%)...
Traditional targeting methods for thalamic deep brain stimulation (DBS) performed to address tremor have predominantly relied on indirect atlas-based that focus the ventral intermediate nucleus despite known variability in functional anatomy. Improvements preoperative may help maximize outcomes and reduce DBS–related complications. In this study, we evaluated ability of parcellation with structural connectivity–based segmentation (SCBS) predict improvement following DBS. retrospective...
<h3>BACKGROUND AND PURPOSE:</h3> Although globus pallidus internus deep brain stimulation is a widely accepted treatment for Parkinson disease, there persistent variability in outcomes that not yet fully understood. In this pilot study, we aimed to investigate the potential role of segmentation using probabilistic tractography as supplement traditional targeting methods. <h3>MATERIALS METHODS:</h3> Eleven patients undergoing were included retrospective analysis. Using multidirection...
Gene replacement therapy is a rational therapeutic strategy and clinical intervention for neurodegenerative disorders like Canavan disease, leukodystrophy caused by biallelic mutations in the aspartoacylase (
Purpose: This study evaluated beam quality and radiation dosimetry of a CT scanner equipped with novel detector filtration technology called PureVision Optics (PVO). PVO features miniaturized electronics, cut microblade technology, increased in order to increase x-ray detection reduce image noise. Methods: We assessed the performance two similar 320-detector scanners: one without. Beam was measured by determining half-value layer (HVL) effective energy ( E eff ) for both scanners using all...
Traumatic dural arteriovenous fistula (dAVF) formation rarely occurs following calvarial fractures. dAVFs, if untreated, may rupture, causing devastating intracranial hemorrhage, and the presence of cortical venous drainage increases risk rupture mortality. A female in her sixth decade life developed a traumatic dAVF middle meningeal artery (MMA) after being hit by motor vehicle. The MMA drained into superior petrosal sinus vein Labbe consistent with Cognard grade 3 lesion. This was...
Accurate and repeatable measurement of high-grade glioma (HGG) enhancing (Enh.) T2/FLAIR hyperintensity/edema (Ed.) is required for monitoring treatment response. 3D measurements can be used to inform the modified Response Assessment in Neuro-oncology criteria. We aim develop an HGG volumetric visualization AI algorithm that generalizable repeatable.A single 3D-Convoluted Neural Network, NS-HGlio, analyze on MRIs using 5-fold cross validation was developed retrospective (557 MRIs),...
<h3>BACKGROUND AND PURPOSE:</h3> Although it is a potentially powerful presurgical tool, fMRI can be fraught with artifacts, leading to interpretive errors, many of which are not fully accounted for in routinely applied correction methods. The purpose this investigation was evaluate the effects data denoising by independent component analysis patients undergoing preoperative evaluation glioma resection compared more methods such as realignment or motion scrubbing. <h3>MATERIALS METHODS:</h3>...
The presence of pregnancy in a brain-dead woman is rare circumstance. We present case 31-year-old who was 22 weeks pregnant at the time diagnosis brain death after intracranial and subarachnoid hemorrhage. After multidisciplinary approach, decision made to continue somatic support maintain until optimal fetus viability. Cesarean section performed 11 (33 gestational age) brain-death with successful delivery live infant. Management complications during described.