A5103088535- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Immune cells in cancer
- Plant Molecular Biology Research
- Pancreatic and Hepatic Oncology Research
- Spinal Cord Injury Research
- Botulinum Toxin and Related Neurological Disorders
- Autophagy in Disease and Therapy
- Phagocytosis and Immune Regulation
- Colorectal Cancer Surgical Treatments
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- 14-3-3 protein interactions
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
- Connexins and lens biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytoplasmas and Hemiptera pathogens
- Luminescence and Fluorescent Materials
- Neurological disorders and treatments
- Plant tissue culture and regeneration
Qilu Hospital of Shandong University
2016-2025
Shandong University
2022-2023
Peking University Shenzhen Hospital
2023
Shandong First Medical University
2022
Shandong Tumor Hospital
2022
State Key Laboratory of Pharmaceutical Biotechnology
2019
Pharmaceutical Biotechnology (Czechia)
2019
Nanjing University
2019
Wuhan General Hospital of Guangzhou
2011-2015
General Hospital of Guangzhou Military Command
2011-2015
Auxin and brassinosteroids (BRs) are two major growth-promoting phytohormones that shape hypocotyl elongation; however, the cross-talk between auxin BR in this process is not fully understood. In study, we found auxin-induced elongation dependent on brassinazole-resistant 1 (BZR1), a core signaling component. promotes BZR1 nuclear accumulation cells, mitogen-activated protein kinase 3 (MPK3) MPK6, which both activated by whose encoding genes highly expressed hypocotyls. We determined...
Type A Botulinum neurotoxin (BoNT/A), the most potent poison known to mankind, is produced by Clostridium botulinum type as a complex with neurotoxin-associated proteins (NAPs). Currently BoNT/A in purified and forms are both available therapeutic cosmetic applications treat neuromuscular disorders. Whereas Xeomin® (incobotulinumtoxin A, Merz Pharmaceuticals, Germany) free from complexing proteins, Botox® (onabotulinumtoxin Allergan, USA) contains NAPs, which themselves have no role...
A novel donor-acceptor-donor (D-A-D) polymer, named PTPAS, incorporating triphenylamine group as the donor and sulfone acceptor, has been designed synthesized. PTPAS was efficiently prepared using readily...
In plant roots, the identity of stem cell niche (SCN) is maintained by an auxin gradient with its maximum in quiescent center (QC). Optimal levels signaling are essential for root SCN identity, but regulatory mechanisms that control this pathway largely unknown. Here, we find zinc finger transcription factor sensitive to proton rhizotoxicity 1 (STOP1) regulates negative feedback tips. Mutation and overexpression STOP1 both affect QC division distal differentiation root. We treatment...
Silver nanoparticles (AgNPs) possess anti-inflammatory activities and have been widely deployed for promoting tissue repair. Here we explored the efficacy of AgNPs on functional recovery after spinal cord injury (SCI). Our data indicated that, in a SCI rat model, local delivery could significantly recover locomotor function exert neuroprotection through reducing pro-inflammatory M1 survival. Furthermore, comparison with Raw 264.7-derived M0 M2, higher level uptake more pronounced...
We aimed to investigate clinical implications of specific soluble immune checkpoint molecules (sICMs) in locally advanced rectal cancer (LARC) patients treated with neoadjuvant chemoradiotherapy (nCRT).We prospectively enrolled 30 LARC nCRT and collected blood samples from them before, during, after for prospective studies. Immune checkpoints often refer T cell surface influencing the response. checkpoints, form a monomeric form, is widely present blood. In study, eight checkpoint-related...
Objective To compare the performances, tolerability and acceptability of mannitol polyethylene glycol (PEG) as oral contrast agents in patients undergoing computed tomography enterography (CTE). Methods Patients aged 18‐75 years indicated for CTE were randomized to receive either or PEG agents. The coronal reconstructed images each abdominal quadrant assessed maximum distention, proportion distended bowel loops, presence inhomogeneous contents visibility small wall. Overall subjective...
Macrophage-mediated inflammation has a significant bursting period and restoring period, which suggests the presence of intrinsic anti-inflammatory mechanisms. Here, we reported dynamic regulator, cytoplasmic deoxyguanosine kinase (dGK), in process macrophage polarization homeostasis. Firstly, confirmed positive correlation between dGK procedure classically activated macrophages polarization. Moreover, was proved to maintain STAT1 phosphorylation via binding C-terminal domain STAT1,...