A5072459165- Poetry Analysis and Criticism
- Wittgensteinian philosophy and applications
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Samuel Beckett and Modernism
- Breast Cancer Treatment Studies
- Art, Politics, and Modernism
- Modernist Literature and Criticism
- French Literature and Poetry
- Antioxidant Activity and Oxidative Stress
- Translation Studies and Practices
- Oral Health Pathology and Treatment
- Genetic factors in colorectal cancer
- Philosophy, Ethics, and Existentialism
- Oral and gingival health research
- Cancer Treatment and Pharmacology
- American and British Literature Analysis
- Biotin and Related Studies
- Sirtuins and Resveratrol in Medicine
- Philosophy, Science, and History
- Contemporary Literature and Criticism
- HER2/EGFR in Cancer Research
- Digital Humanities and Scholarship
- Philosophy and History of Science
- Historical and Literary Studies
National Cancer Institute
2016-2025
Stanford University
2011-2024
National Cancer Institute
2015-2024
University of Southern California
1979-2019
Northwestern University
2011-2019
Southern California University for Professional Studies
1979-2019
National Institutes of Health
1993-2019
The University of Texas MD Anderson Cancer Center
2019
IIT Research Institute
2019
Cedars-Sinai Medical Center
2019
Abstract The red grape constituent resveratrol possesses cancer chemopreventive properties in rodents. hypothesis was tested that, healthy humans, p.o. administration of is safe and results measurable plasma levels resveratrol. A phase I study oral (single doses 0.5, 1, 2.5, or 5 g) conducted 10 volunteers per dose level. Resveratrol its metabolites were identified urine by high-performance liquid chromatography-tandem mass spectrometry quantitated chromatography-UV. Consumption did not...
Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in preclinical models. It been shown to downregulate the levels of insulin-like growth factor-1 (IGF-I) rodents. The purpose study was assess its safety, pharmacokinetics, and effects on circulating IGF-I IGF-binding protein-3 (IGFBP-3) after repeated dosing. Forty healthy volunteers ingested resveratrol at 0.5, 1.0, 2.5, or 5.0 g daily for 29 days. Levels metabolites were measured by high performance liquid...
Resveratrol is a phytochemical with chemopreventive activity in preclinical rodent models of colorectal carcinogenesis. Antiproliferation one the many modes action it has been shown to engage in. Concentrations resveratrol, which can be achieved human tissues after p.o. administration, have not yet defined. The purpose this study was measure concentrations resveratrol and its metabolites tissue humans who ingested resveratrol. Twenty patients histologically confirmed cancer consumed eight...
BACKGROUND: Fenretinide, a vitamin A analogue, has been shown to inhibit breast carcinogenesis in preclinical studies. We determined the efficacy of fenretinide preventing second malignancy women with cancer. METHODS: randomly assigned 2972 women, aged 30-70 years, surgically removed stage I cancer or ductal carcinoma situ receive for 5 years either orally (200 mg/day) no treatment. The primary end point was incidence contralateral ipsilateral 7 after randomization. Other points considered...
Abstract Resveratrol has been shown to exhibit cancer-preventive activities in preclinical studies. We conducted a clinical study determine the effect of pharmacologic doses resveratrol on drug- and carcinogen-metabolizing enzymes. Forty-two healthy volunteers underwent baseline assessment cytochrome P450 (CYP) phase II detoxification CYP1A2, CYP2D6, CYP2C9, CYP3A4 enzyme were measured by metabolism caffeine, dextromethorphan, losartan, buspirone, respectively. Blood lymphocyte glutathione...
List of Plates.Acknowledgments.Introduction.1 Avant-Garde Eliot.2 Gertrude Stein's Differential Syntx.3 The Conceptual Poetics Marcel Duchamp.4 Khlebnikov's Soundscapes: Letter, Number, and the Zaum.5 Modernism at Millennium.Notes.Bibliography.Index.
Journal Article Columbia Literary History of the United States. Ed. by Emory Elliott, Martha Banta, Terence Martin, David Minter, Marjorie Perloff, and Daniel B. Shea. (New York: University Press, 1988. xxviii + 1263 pp. $59.95.) Get access James W. Tuttleton New York Search for other works this author on: Oxford Academic Google Scholar American History, Volume 75, Issue 3, December 1988, Pages 907–908, https://doi.org/10.2307/1901574 Published: 01 1988
Drawing extensively upon the poet's unpublished manuscripts - poems, journals, essays, and letters as well all his published works, Marjorie Perloff presents Frank O'Hara one of central poets postwar period an important critic visual arts. traces development through early years at Harvard interest in French Dadaism Surrealism to later poems that fuse literary influence with elements from Abstract Expressionist painting, atonal music, contemporary film. This edition contains a new...
Patients with Lynch syndrome (LS) are at markedly increased risk for colorectal cancer. It is being increasingly recognised that the immune system plays an essential role in LS tumour development, thus making ideal target cancer prevention. Our objective was to evaluate safety, assess activity and discover novel molecular pathways involved of naproxen as primary secondary chemoprevention patients LS.
Oral premalignancy serves as an ideal model for study of chemopreventive agents. Although 13-cis-retinoic acid showed reversal oral premalignancy, toxicity, and clinical response after cessation therapy obviated its widespread use. A search nontoxic agents with cancer preventive activity led us to evaluate Bowman Birk Inhibitor (BBI) formulated BBI Concentrate (BBIC). We previously reported encouraging results in a phase IIa trial BBIC patients leukoplakia measurable responses favorable...
The possible link between psychological factors and length of cancer survival has generated a literature contradictory findings. Associations usually have not been found when general symptoms are assessed. for predictors related to expressive versus repressive emotional coping (e.g., depression, “fighting spirit,” hostility, type C personality); however, even these associations relatively small, compared with those medical factors. Yet few studies adequately controlled treatment-related...
Marjorie Perloff, among our foremost critics of twentieth-century poetry, argues that Ludwig Wittgenstein provided writers with a radical new aesthetic, key to recognizing the inescapable strangeness ordinary language. Taking seriously Wittgenstein's remark philosophy ought really be written only as form Perloff begins by discussing poet. What we learn is poetics everyday life anything but banal.This book has lucidity and intelligence have come expect from Perloff.--Linda Munk, American...
Abstract Meta-analyses have reported a decrease in overall cancer incidence of approximately 10-40% with metformin use among individuals diabetes. Lifestyle change could potentially reduce incidence. The objective was to determine whether or intensive lifestyle intervention (ILS) reduces the risk adults at high Diabetes Prevention Program (DPP, 1996-2001) randomized 3234 participants ILS, (850 mg twice daily), blinded placebo. During follow-up through DPP Outcomes Study (DPPOS), all were...
This study was conducted to determine the safety and efficacy of green tea-derived Polyphenon E (Poly E) in patients with Barrett's Esophagus (BE). Subjects were randomized a 6-month, twice daily (BID) oral treatment placebo or Poly (200, 400, 600 mg). Endoscopic evaluation, including biopsies, performed before after treatment. The primary objective demonstrate safety; secondary objectives investigated catechin accumulation effects clinical specimens. Of 44 enrolled subjects, 11 received...
Breast cancer prevention only requires local exposure of the breast to active drug. However, oral preventive agents entail systemic exposure, causing adverse effects that limit acceptance by high-risk women. Drug-delivery through skin is an attractive option, but demonstration dermal safety and drug distribution throughout breast. We formulated tamoxifen metabolite (E/Z)-endoxifen for transdermal delivery tested it in a placebo-controlled, double-blinded Phase I trial with dose escalation...
Why Pyrenees? Surely Gogo is longing for more than a pleasant mountain idyll. In the original French version, Beckett specifies fully: Nous irons, tells Didi, dans l'Ari?ge, and he adds, J'ai toujours voulu me balader l'Ari?ge. The joke here that Ari?ge was hardly place suitable wandering. Also known asLe Chemin de la Libert? (later title of Sartre's trilogy novels), it chief World War II escape route from