A5078598511- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Estrogen and related hormone effects
- Nutrition, Genetics, and Disease
- Cancer Treatment and Pharmacology
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Medical Imaging Techniques and Applications
- Metabolism, Diabetes, and Cancer
- AI in cancer detection
- Bioinformatics and Genomic Networks
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Pain Management and Opioid Use
- Nausea and vomiting management
- Prenatal Screening and Diagnostics
University of Michigan
2022-2025
Michigan Medicine
2024-2025
Memorial Sloan Kettering Cancer Center
2015-2024
Northwestern University
2011-2019
IIT Research Institute
2019
National Institutes of Health
2019
Cedars-Sinai Medical Center
2019
Case Western Reserve University
2019
European Neuroendocrine Tumor Society
2018
American College of Surgeons
2015-2017
Purpose The increased breast cancer risk conferred by a diagnosis of lobular carcinoma in situ (LCIS) is poorly understood. Here, we review our 29-year longitudinal experience with LCIS to evaluate factors associated risk. Patients and Methods participating surveillance after an are observed prospectively maintained database. Comparisons were made among women choosing surveillance, or without chemoprevention, those undergoing bilateral prophylactic mastectomies between 1980 2009. Results One...
Prospective trials have demonstrated sentinel lymph node (SLN) false-negative rates of less than 10% when 3 or more SLNs are retrieved in patients with clinically node-positive breast cancer rendered node-negative neoadjuvant chemotherapy (NAC). However, nodal recurrence such treated SLN biopsy (SLNB) alone unknown because axillary dissection (ALND) was performed all patients, limiting adoption this approach.To evaluate a consecutive cohort (cN1) receiving NAC, followed by negative SLNB...
Abstract Background Racial disparities in breast cancer survival between Black and White women persist across all stages of cancer. The metabolic syndrome (MetS) insulin resistance disproportionately affects more than women. It has not been discerned if mediates the link race poor prognosis We aimed to determine whether part association prognosis, receptor (IR) insulin-like growth factor (IGF-1R) expression differs tumors from Methods conducted a cross-sectional, multi-center study ten...
Abstract Background: In patients with micro- and macrometastases in the sentinel lymph node (SLN) after neoadjuvant chemotherapy (NAC), additional positive nodes are found >60% of cases axillary dissection (ALND) is currently considered standard care. The likelihood finding residual isolated tumor cells (ITCs) unknown, benefit ALND unclear. As a consequence, surgical management axilla these not standardized. We sought to evaluate how often found, determine factors associated ALND,...
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
To investigate the value of contrast-enhanced mammography (CEM) compared to full-field digital (FFDM) in screening breast cancer patients after breast-conserving surgery (BCS), this Health Insurance Portability and Accountability Act-compliant, institutional review board-approved retrospective, single-institution study included 971 CEM exams 541 asymptomatic treated with BCS who underwent between January 2013 November 2018. Histopathology, or at least a one-year follow-up, was used as...
Abstract Background Nipple-sparing mastectomy is associated with a higher risk of skin-flap necrosis than conventional skin-sparing mastectomy. There are limited prospective data examining modifiable intraoperative factors that contribute to after nipple-sparing Methods Data on consecutive patients undergoing between April 2018 and December 2020 were recorded prospectively. Relevant variables documented by both breast plastic surgeons at the time surgery. The presence extent nipple and/or...
Abstract Purpose. We conducted a mouse–human co-clinical trial to evaluate the biological efficacy of exercise therapy in breast cancer prevention. Materials and methods. In phase 1 randomized trial, 75 nonexercising women at high-risk were allocated receive (1:1 ratio): usual care or one three dose regimens: 75, 150, 300 minutes/week for 24 consecutive weeks. Biological was evaluated by changes epithelial cell proliferation (Ki67). Correlative proteomic analysis paired tissue plasma samples...