A5041687687- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Probiotics and Fermented Foods
- Vector-Borne Animal Diseases
- Trace Elements in Health
- Viral Infections and Vectors
- Metabolomics and Mass Spectrometry Studies
- Religion, Society, and Development
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Virus Infections Studies
- Vector-borne infectious diseases
- Escherichia coli research studies
- Vitamin C and Antioxidants Research
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Rabbits: Nutrition, Reproduction, Health
- Iron Metabolism and Disorders
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Viral Infections and Outbreaks Research
- Parasites and Host Interactions
- Plant Virus Research Studies
Centers for Disease Control and Prevention
2024
University of California, Davis
2013-2022
University of California, San Francisco
2012
Citrobacter rodentium uses a type III secretion system (T3SS) to induce colonic crypt hyperplasia in mice, thereby gaining an edge during its competition with the gut microbiota through unknown mechanism. Here, we show that by triggering hyperplasia, C. T3SS induced excessive expansion of undifferentiated Ki67-positive epithelial cells, which increased oxygenation mucosal surface and drove aerobic colon. Treatment mice γ-secretase inhibitor dibenzazepine diminish Notch-driven curtailed...
5-Aminosalicylic acid (5-ASA), a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is widely used first-line medication for the treatment of ulcerative colitis, but its anti-inflammatory mechanism not fully resolved. Here, we show that 5-ASA ameliorates colitis in dextran sulfate sodium (DSS)-treated mice by activating PPAR-γ signaling intestinal epithelium. DSS-induced was associated with loss epithelial hypoxia and respiration-dependent luminal expansion Escherichia coli,...
Changes in the microbiota composition are associated with many human diseases, but factors that govern strain abundance remain poorly defined. We show a commensal Escherichia coli and pathogenic Salmonella enterica serovar Typhimurium isolate both utilize nitrate for intestinal growth, each accesses this resource distinct biogeographical niche. Commensal E. utilizes epithelial-derived nitrate, whereas niche occupied by S. is derived from phagocytic infiltrates. Surprisingly, avirulent was...
Abstract Childhood malaria is a risk factor for disseminated infections with non-typhoidal Salmonella (NTS) in sub-Saharan Africa. While hemolytic anemia and an altered cytokine environment have been implicated increased susceptibility to NTS, it not known whether affects resistance intestinal colonization NTS. To address this question, we utilized murine model of co-infection. Infection mice Plasmodium yoelii elicited infiltration inflammatory macrophages T cells into the mucosa expression...
Abstract A colony of domestic rabbits in Tennessee, USA, experienced a high-mortality (~90%) outbreak enterocolitis. The clinical characteristics were one to six days lethargy, bloating, and diarrhea, followed by death. Heavy intestinal coccidial load was consistent finding as mucoid enteropathy with cecal impaction. Preliminary analysis electron microscopy revealed the presence virus-like particles stool affected rabbits. Analysis using Virochip, viral detection microarray, suggested an...
Type of feed is an important consideration in herbivore colony management, yet limited studies report on the effects diet common conditions such as urolithiasis guinea pigs. Urolithiasis a well-documented cause lower urinary tract disease pigs, with calcium carbonate uroliths reported predominant calculi formed pig tract. A calcium-rich has been suggested risk factor for urolithiasis, numerous commercially available diets formulated adults avoiding ingredients that are higher calcium. Due to...
Disseminated disease from non-typhoidal Salmonella enterica strains results in >20% mortality globally. Barriers to effective treatment include emerging multidrug resistance, antibiotic failure, and risk factors such as malnutrition related micronutrient deficiencies. Individuals sub-Saharan Africa are disproportionately affected by S. bloodstream infections. To inform a clinical trial people, we investigated vitamin A the context of failure mouse model deficiency. Vitamin A-deficient (VAD)...
In recent years, many spore-forming commensal Clostridia found in the gut have been discovered to promote host physiology, immune development, and protection against infections. We provide a detailed protocol for rapid enrichment of bacteria from murine intestine. Briefly, contents intestinal cecum are collected aerobically, diluted finally treated with chloroform enrich spores.