A5032499291- Asymmetric Hydrogenation and Catalysis
- Surface Chemistry and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Wheat and Barley Genetics and Pathology
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Catalysis for Biomass Conversion
- Carbohydrate Chemistry and Synthesis
- Protist diversity and phylogeny
- Food composition and properties
- RNA and protein synthesis mechanisms
- Organometallic Complex Synthesis and Catalysis
- HIV/AIDS drug development and treatment
- Advanced Fiber Laser Technologies
- Agricultural Productivity and Crop Improvement
- Click Chemistry and Applications
- Silicon Effects in Agriculture
- Cancer, Hypoxia, and Metabolism
- Advanced Synthetic Organic Chemistry
- Axial and Atropisomeric Chirality Synthesis
Fuzhou University
2024-2025
Nanjing Foreign Language School
2025
State Key Laboratory of Medicinal Chemical Biology
2016-2024
Nankai University
2012-2024
Guangdong University of Technology
2021-2022
Shanghai Customs College
2022
Northwestern Polytechnical University
2021
Ministry of Industry and Information Technology
2021
Tianjin Institute of Pharmaceutical Research (China)
2021
Nanjing University of Science and Technology
2020
To further meet the application needs of lithium-ion batteries, developing cathodes with higher voltage and operating temperatures has become a primary goal. However, LiCoO2 encounter structural issues, particle fracture, side reactions during high-voltage high-temperature cycling. Thus, this work designs novel interface engineering approach involving near-surface Li layer regulation enhances stability R3̄m layered structure, suppressing intergranular cracking. An undistorted surface reduced...
We report the first high-resolution structural data for β/γ-peptide 13-helix (i,i+3 C═O···H—N H-bonds), a secondary structure that is formed by oligomers with 1:1 alternation of β- and γ-amino acid residues. Our characterization includes both crystallophaphic 2D NMR data. Previous studies suggested β/γ-peptides constructed from conformationally flexible residues adopt different helical in solution. design features preorganized γ-residues, which strongly promote 13-helical folding β/γ backbone.
In recent years, polymer films containing deep color and near-infrared (NIR)-reflective pigments have received much attention for their potential applications in energy-saving fields. However, practical environments, dust present the air is easily adsorbed adheres to surface of these films, thus gradually reducing NIR reflectance. this work, black or deep-red infrared-reflective were firstly mixed with melted low-density polyethylene (LDPE) then resulting composite was thermally pressed on a...
Direct condensation of β-arylketones with acetamide afforded both Z and E enamides. The Z-configured substrates underwent hydrogenation excellent enantioselectivity by using the Rh/tangphos catalytic system (see scheme; tangphos=1,1′-di-tert-butyl-[2,2′]-diphospholanyl). product β-arylisopropylamines are important precursors to several drugs.
Valuable chiral building blocks were synthesized with excellent enantioselectivity and diastereoselectivity through tandem hydrogenation of (Z)-β-ketoenamides, which in turn prepared by the direct condensation 1,3-diketones acetamide (see scheme). The amino alcohol products can be converted into useful γ-aryl isobutylamines hydrogenolysis Pd/C. R1=aryl, heteroaryl, methyl; R2=alkyl.
New couple: A novel combination of phosphine and phosphoramidite groups is applied to the preparation pseudo-C2-symmetric triphosphorous bidentate phosphine–phosphoramidite ligands 1. Unprecedented enantioselectivities toward ortho-substituted aryl enamides a 1-naphthylenamide in Rh-catalyzed hydrogenation reactions are obtained.
All wound up: Crystallographic data for a set of homologous peptides constructed from gabapentin and two to six preorganized γ-amino acid residues (see crystal structure the longest peptide) allow derivation characteristic parameters γ-peptide 14-helix establish guidelines characterizing 14-helical folding. The results suggest that substitution pattern γ-residue has profound effect on propensity Detailed facts importance specialist readers are published as "Supporting Information". Such...
An asymmetric synthesis of two new diastereomeric γ-amino acids is described. Both molecules contain a cyclohexyl ring to limit conformational flexibility about the Cα–Cβ bond; they differ in having cis vs trans stereochemistry on ring. Residues derived from γ isomer are shown support helical secondary structures α/γ-peptide oligomers.
Recently, infrared reflective pigments possessing deep colors have attracted much attention. However, in polluted air, the coatings consisting of such are easily contaminated which abates reflectivity. In this work, black and pigments, fluorine silicon sol a small number SiO2 nanoparticles were introduced into waterborne epoxy resin emulsion then coated on an aluminum plate. After drying, with superhydrophobic (SH) properties obtained. The average near-infrared (NIR) reflectivity coating...
Nannocystin A is a 21-membered cyclodepsipeptide showing remarkable anticancer properties. Described the total synthesis of nannocystin A, which features an asymmetric vinylogous Mukaiyama aldol reaction for efficient assembly penultimate open-chain precursor and pivotal intramolecular Heck cross-coupling final macrocyclization.
Eukaryotic elongation factor 1A (eEF1A) is among the most abundant proteins in eukaryotic cells. Evolutionarily conserved across species, eEF1A charge of translation for protein biosynthesis as well a plethora non-translational moonlighting functions cellular homeostasis. In malignant cells, however, becomes pleiotropic driver cancer progression via broad diversity pathways, which are not limited to hyperactive translational output. past decades, mounting studies have demonstrated causal...
A new spirocyclic diol, 9,9'-spirobixanthene-1,1'-diol, was synthesized in two steps from readily available starting material m-phenoxyanisole. Resolution of the racemic diol achieved by cocrystallization with N-benzylcinchonidinium chloride and N-benzylquininium acetonitrile. The corresponding spiro monodentate phosphoramidite ligand has been prepared for Rh-catalyzed asymmetric hydrogenation α-dehydroamino acid derivatives itaconic excellent enantioselectivities (up to >99% ee).
Tough reprocessable and self-healable acrylonitrile-butadiene rubber (NBR) is developed by grafting 2-ureido-4[1<italic>H</italic>]-pyrimidinone groups onto the backbone of amidoxime NBR, representing a big step in recyclable high-performance NBR.
In recent years, CRC has gradually become one of the most common and deadliest types cancer worldwide. Numerous studies in modern biology have explored gut microbiota, revealing an inseparable relationship between microbial composition development. Currently, multiple articles suggest that products can help promote or inhibit formation tumor microenvironment, while different dietary reshape distribution microbiota. This retrospective article aims to summarize previous experimental findings...
An X-ray diffraction experiment revealed an interesting triphosphorous bidentate coordination in a Pd(II) complex of phosphine-phosphoramidite ligand 1, which showed excellent enantioselectivity (up to 99.4% ee) Rh-catalyzed hydrogenation α-dehydroamino esters acetone. A dramatic solvent effect was found the itaconates, induces opposite chiralities product with same catalytic system by use different solvents (e.g., 99.6% ee (R) TFE vs 71.2% (S) methyl ethyl ketone).
Abstract Asymmetric total synthesis of the cyclic depsipeptide BE‐43547A 2 was achieved in 15 linear steps on a 350 mg scale one batch. The features highly diastereoselective construction an α‐hydroxy‐β‐ketoamide through α‐hydroxylation with d.r. up to 86:1. significantly reduces percentage pancreatic cancer stem cells (PCSCs) Panc‐1 cell cultures, and dramatically tumorsphere‐forming capability cells. An vivo tumor‐initiation assay, gold standard for assays, confirmed that can abolish...
A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation these substrates with TangPhos gave products good to excellent enantioselectivities (up 99% ee).