A5058085299- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- COVID-19 and Mental Health
- Parasitic Diseases Research and Treatment
- HIV/AIDS Research and Interventions
- Epilepsy research and treatment
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 epidemiological studies
- Hepatitis Viruses Studies and Epidemiology
- Parasite Biology and Host Interactions
- COVID-19 Impact on Reproduction
- Antibiotic Resistance in Bacteria
- Infection Control and Ventilation
- Oil, Gas, and Environmental Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Cerebrospinal fluid and hydrocephalus
- Pancreatic and Hepatic Oncology Research
- Liver Diseases and Immunity
- Antiplatelet Therapy and Cardiovascular Diseases
- Plant Pathogenic Bacteria Studies
- Infectious Encephalopathies and Encephalitis
- SARS-CoV-2 detection and testing
- Parasites and Host Interactions
Antwerp University Hospital
2016-2024
University of Antwerp
2016-2024
Ghent University Hospital
2022-2024
AZ Sint-Lucas
2023-2024
Onze Lieve Vrouwziekenhuis Hospital
2022
Erasmus MC
2017
We investigated the level of willingness for COVID-19 vaccination in Democratic Republic Congo (DRC). Data were collected between 24 August 2020 and 8 September through an online survey. A total 4131 responses included; mean age respondents was 35 years (standard deviation: 11.5); 68.4% females; 71% had elementary or secondary school education. One fourth (24.1%) convinced that did not exist. Overall, 2310 (55.9%) indicated they willing to be vaccinated. In a multivariable regression model,...
INTRODUCTION: Despite improvements in the management of chronic hepatitis B (CHB), risk cirrhosis and hepatocellular carcinoma remains. While surface antigen loss is optimal end point, safe discontinuation nucleos(t)ide analog (NA) therapy controversial because possibility severe or fatal reactivation flares. METHODS: This a multicenter cohort study virally suppressed, end-of-therapy (EOT) e (HBeAg)-negative CHB patients who stopped NA (n = 1,557). Survival analysis techniques were used to...
Background: Empirical data on the consequences of novel coronavirus disease (COVID-19) pandemic HIV care are lacking. We surveyed people living with (PLWH) in different countries to investigate whether their medical follow-up and psychosocial well-being had been compromised due COVID-19 associated restrictions. Methods: In April 2020, a cross-sectional survey among PLWH was conducted using web-based multilingual questionnaire. The research tool assessed follow-up, well-being, (flu-like)...
Summary Background Stopping nucleos(t)ide analogues (NA) after hepatitis B e antigen ( HB eAg) seroconversion is associated with high relapse rates in Asian patients, but data Caucasian cohorts are scarce. Clinical course, outcomes and immunological aspects of chronic infections differ substantially between distinct ethnicities. Aim The aim this study was to determine rates, factors predicting clinical analogue cessation a large, predominantly cohort patients analogue‐induced eAg...
To evaluate the impact of coronavirus disease 2019 (COVID-19) measures on lives and psychosocial well-being persons with epilepsy (PWE) during third trimester COVID-19 pandemic.A structured questionnaire investigating different aspects PWE pandemic was developed. Persons were invited via social media to anonymously respond a secure web-based online (www.icpcovid.com). Responses collected between July 26th December 3rd, 2020. Hospital anxiety depression scales (HADS) used screen respondents...
<h2>Abstract</h2><h3>Background and Aims</h3> Flares after nucleos(t)ide analogue (NA) cessation are common potentially harmful. Predictors of flares required for risk stratification to guide off-treatment follow-up. <h3>Method</h3> This multicenter cohort study included virally suppressed patients with chronic hepatitis B (CHB) who were e antigen negative at NA cessation. Hepatic defined based on an ALT-levels ≥5-, 10- or 20 x upper limit normal (ULN). Multivariable Cox regression analyses...
In 70 chronic hepatitis B patients with surface antigen seroclearance during nucleos(t)ide analogue therapy, response was sustained in all 54 who discontinued treatment. Clinically significant relapses as indicated by high virus DNA and ALT levels were not observed. Anti-HBs positivity may be required to ensure off-treatment response.
Whether entecavir (ETV) and tenofovir disoproxil fumarate (TDF) differentially affect relapse outcomes following treatment discontinuation across different patient subpopulations remains unclear. We aimed to compare rates of off-therapy hepatitis B surface antigen (HBsAg) loss, virological clinical relapse, retreatment between chronic (CHB) patients who discontinued TDF or ETV therapy.This study included 1402 virally suppressed CHB stopped either (n = 981) 421) therapy 2001 2020 from 13...
Adherence to preventive measures is essential reduce the risk of COVID-19 transmission. Two online surveys were conducted in Democratic Republic Congo (DRC) from 23 April 8 June 2020, and August 24th September 8th, respectively. A total 3268 (round 1) 4160 2) participants included. In both surveys, there was a moderate level adherence regular handwashing (85% 77%, respectively), wearing facemasks (41.4% 69%, respecting physical distancing (58% 43.4%, respectively). The second survey found...
COVID-19 affects persons living with HIV (PLWH) both directly (via morbidity/mortality) and indirectly disruption of care). From July–November 2020, an online survey was conducted to investigate the psychosocial well-being PLWH changes in care during second semester outbreak. Data were collected on socio-demographic characteristics PLWH, their well-being, impact preventive measures daily routines follow-up. Of 247 responses analyzed (mean age: 44.5 ± 13.2 years; 73.7% male), 67 (27.1%) 69...
During the COVID-19 pandemic, healthcare workers (HCW) have been subjected to greater workloads. We conducted a cross-sectional online survey assess impact of pandemic on Brazilian HCW. Data were collected between 11 August and 1 November 2020. Of 295 respondents, 95 (32.2%) medical doctors, 82 (27.8%) administrative staff, 53 (18.0%) nurses, 27 (9.2%) laboratory 38 (12.9%) other staff. COVID-19-related restructuring at health facilities was reported by 207 (70.2%) 69 (23.4%) had their tasks...
It is well appreciated that ethnicity influences the natural history and immune responses during a chronic hepatitis B infection. In this study, we explore effect of treatment cessation on Hepatitis surface Antigen (HBsAg) seroclearance in patients with Nucleos(t)ide Analogue (NA)-induced e (HBeAg) seroconversion. We performed multi-ethnic, multicentric observational cohort study. The analyzed consisted 178 mono-infected, predominantly male (75.3%) mixed (44.4% Asians, 48.9% Caucasians)...
Mixta calida, previously known as Pantoea was initially isolated from powdered infant milk in 2010. It falls within the Erwiniaceae family (class: Enterobacterales). While calida traditionally regarded non-pathogenic, we now present a case of bacteraemia and meningitis 5-week-old child, successfully treated with cefotaxime. This case, contrast to prior reports potential contamination issues, is first offer compelling evidence calida's pathogenicity humans.
Background and aims Historical paired liver biopsy studies are likely to underestimate current progression of disease in patients with chronic hepatitis C virus (HCV) infection. We aimed assess according the non-invasive Fibrosis-4 (FIB-4) index HCV early disease. Methods results Patients diagnosed FIB-4 <3.25 from four international clinics were included a retrospective cohort study. Follow-up ended at start antiviral therapy resulting sustained virological response, time transplantation...
Introduction: Viral hepatitis is a worldwide, important health issue. The optimal management of viral infections faces numerous challenges. In this paper, we describe how biobanking biological samples derived from patients collected both in-hospital and during community outreach screenings provides unique collection samples. Materials Methods: All materials were provided with study code within the SLIMS system Study protocols an informed consent form approved by Antwerp University...
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Exhaustion of antigen-specific T-cells in order to escape immune destruction is frequently seen chronic viral infection and different types cancer. Blockade overexpressed negative co-stimulatory pathways, a process known as checkpoint modulation, promising novel therapy that could improve the treatment liver diseases with features T cell exhaustion. We present case 54-year-old hepatitis C virus (HCV) positive patient an acute flare during nivolumab for stage IV lung carcinoma,...