A5090993644- Mycotoxins in Agriculture and Food
- Meat and Animal Product Quality
- Probiotics and Fermented Foods
- Veterinary medicine and infectious diseases
- Wheat and Barley Genetics and Pathology
- Plant and fungal interactions
- Plant Pathogens and Fungal Diseases
- Radiation Therapy and Dosimetry
- NF-κB Signaling Pathways
- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Microbial infections and disease research
- Fungal and yeast genetics research
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Bacillus and Francisella bacterial research
- Phytoestrogen effects and research
- Plant Disease Resistance and Genetics
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Advanced Chemical Sensor Technologies
- Indoor Air Quality and Microbial Exposure
- Receptor Mechanisms and Signaling
- Milk Quality and Mastitis in Dairy Cows
- Renin-Angiotensin System Studies
École Nationale Vétérinaire de Toulouse
2018-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2022
Toxalim Research Centre in Food Toxicology
2017-2022
Université Toulouse III - Paul Sabatier
2018-2022
Université de Toulouse
2018-2022
National Nuclear Energy Commission
2002
Food and feed can be naturally contaminated by several mycotoxins, concern about the hazard of exposure to mycotoxin mixtures is increasing. In this study, more than 800 metabolites were analyzed in 524 finished pig samples collected worldwide. Eighty-eight percent co-contaminated with deoxynivalenol (DON) other regulated/emerging mycotoxins. The Top 60 emerging/regulated mycotoxins co-occurring DON shows that 48%, 13%, 8% 12% are produced Fusarium, Aspergillus, Penicillium Alternaria...
Abstract The few data available on fusarenon-X (FX) do not support the derivation of health-based guidance values, although preliminary results suggest higher toxicity than other regulated trichothecenes. Using histo-morphological analysis and whole transcriptome profiling, this study was designed to obtain a global view intestinal alterations induced by FX. Deoxynivalenol (DON) served as benchmark. FX more severe histological DON. Inflammation hallmark molecular both mycotoxins. benchmark...
Type B trichothecene mycotoxin deoxynivalenol (DON) is one of the most frequently occurring food contaminants. By inducing trans-activation a number pro-inflammatory cytokines and increasing stability their mRNA, can impair intestinal health. Several yeast products, especially Saccharomyces cerevisiae, have potential for improving enteric health piglets, but little known about mechanisms by which administration counteracts DON-induced alterations. Using pig jejunum explant model,...
Introduction The food contamination by mycotoxins is of increasing public health concerns. Deoxynivalenol (DON), a mycotoxin contaminating cereals, has been associated with the exacerbation inflammatory bowel diseases (IBD), thereby raising question its role in development IBD. Moreover, effect DON on colon poorly described. Methods and Results Wistar rats exposed (1–4 weeks) to low doses (2 or 9 mg kg −1 feed) show microscopic alterations colonic tissue (dilated lymphatic vessels, luminal...
The impact of the Fusarium-derived metabolites beauvericin, enniatin B and B1 (EB) alone or in combination with deoxynivalenol (DON) was investigated 28-29 days old weaning piglets over a time period 14 days. co-application EB DON (EB + DON) led to significant decrease weight gain animals. Liver enzyme activities plasma were significantly decreased at day receiving DON-containing diet compared control diet. All mycotoxin-contaminated diets moderate severe histological lesions jejunum, liver...
The mycotoxin zearalenone (ZEN), which frequently contaminates cereal-based human food and animal feed, is known to have an estrogenic effect. biological response associated with exposure ZEN has rarely been reported in organs other than the reproductive system. In intestine, several studies suggested that might stimulate molecular changes related activation of early carcinogenesis, but mechanisms behind these events are not yet known. this study, we investigated gene expression protein...
NX is a type A trichothecene produced by Fusarium graminearum with limited information on its toxicity. structurally similar to deoxynivalenol (DON), only differing the lacking keto group at C8. Because of structural similarity two toxins as well their potential co-occurrence in food and feed, it interest determine toxicity this new compound. In study, we compared protein composition extracellular media pig intestinal explants (secretome) exposed 10 µM DON or for 4 h controls. The...
The effects of low doses toxicants are often subtle and information extracted from metabolomic data alone may not always be sufficient. As end products enzymatic reactions, metabolites represent the final phenotypic expression an organism can also reflect gene changes caused by this exposure. Therefore, integration transcriptomic could improve biological knowledge on these induced disruptions. In present study, we applied statistical tools to obtained jejunal explants pigs exposed food...