A5033751936- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Plant and fungal interactions
- Wheat and Barley Genetics and Pathology
- Plant Disease Resistance and Genetics
- Indoor Air Quality and Microbial Exposure
- Insect and Pesticide Research
- Veterinary medicine and infectious diseases
- Agricultural safety and regulations
- Ruminant Nutrition and Digestive Physiology
- Alcohol Consumption and Health Effects
- Botanical Research and Chemistry
- Effects and risks of endocrine disrupting chemicals
- Fungal Biology and Applications
- Phytoestrogen effects and research
- Plant Toxicity and Pharmacological Properties
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Bacillus and Francisella bacterial research
- Food composition and properties
- Inflammasome and immune disorders
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Phytochemical Studies and Bioactivities
- Microbial infections and disease research
Université de Montréal
2020-2025
Toxalim Research Centre in Food Toxicology
2011-2024
Université de Toulouse
2013-2024
École Nationale Vétérinaire de Toulouse
2013-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
Université d'Abomey-Calavi
2019-2020
Université Toulouse III - Paul Sabatier
2016-2020
Centre National Hospitalier et Universitaire Hubert Koutoukou MAGA
2018-2019
Hôpital d'instruction des Armées Desgenettes
2016
The mycotoxins deoxynivalenol (DON) and nivalenol (NIV), worldwide cereal contaminants, raise concerns for animal human gut health, following contaminated food or feed ingestion. impact of DON NIV on intestinal mucosa was investigated after acute exposure, in vitro vivo. histological changes induced by were analyzed four-hour exposure pig jejunum explants loops, two alternative models. On explants, dose-dependent increases the NIV, with a two-fold increase lesion severity at 10 µM NIV. had...
Abstract The few data available on fusarenon-X (FX) do not support the derivation of health-based guidance values, although preliminary results suggest higher toxicity than other regulated trichothecenes. Using histo-morphological analysis and whole transcriptome profiling, this study was designed to obtain a global view intestinal alterations induced by FX. Deoxynivalenol (DON) served as benchmark. FX more severe histological DON. Inflammation hallmark molecular both mycotoxins. benchmark...
Type B trichothecene mycotoxin deoxynivalenol (DON) is one of the most frequently occurring food contaminants. By inducing trans-activation a number pro-inflammatory cytokines and increasing stability their mRNA, can impair intestinal health. Several yeast products, especially Saccharomyces cerevisiae, have potential for improving enteric health piglets, but little known about mechanisms by which administration counteracts DON-induced alterations. Using pig jejunum explant model,...
Aflatoxin B1 (AFB1) is the most potent carcinogen among mycotoxins. Its biosynthesis involves formation of versicolorin A (VerA), whose chemical structure shares many features with AFB1. Our data revealed significant levels VerA in foodstuff from Central Asia and Africa. Given this emerging food risk, it was prime interest to compare toxic effects two mycotoxins against cells originating intestinal tract. We used human colon cell lines (Caco-2, HCT116) investigate cytotoxic process induced...
Microbial biotransformation of Zearalenone (ZEN) is a promising deactivation approach. The residual toxicity and stability Zearalenone-14-phosphate (ZEN-14-P) Zearalenone-16-phosphate (ZEN-16-P), two novel microbial phosphorylation products ZEN, remain unknown. We investigated the cytotoxicity, oxidative stress, proinflammatory, estrogenic activity phosphorylated ZENs using porcine intestinal cells, uterine explants, human endometrial cells traced their metabolic fate by liquid...
Trichothecene type A mycotoxins, such as T-2, HT-2, and diacetoxyscirpenol (DAS), are known to induce cytotoxicity apoptosis in different cell types. As all three Fusarium toxins may occur concomitantly a given food or feed commodity, there is growing interest the effect of mycotoxin mixtures. This study aimed identify toxic interactions among DAS human Jurkat model. first step, an MTT assay was used assess after 24 h exposure individual mycotoxins their The results were calculate...
The deoxynivalenol (DON) mycotoxin poses serious health risks, especially to swine, which are highly susceptible intestinal damage. Existing strategies counteract DON toxicity remain insufficient. This study aimed evaluate the protective effects of cannabidiol (CBD), a phytocannabinoid with anti-inflammatory properties, against DON-induced in porcine epithelial cells. Using differentiated and proliferating cells (IPEC-J2), we evaluated CBD (2.5-5 μM) (0.5-50 through viability assays,...
Introduction The food contamination by mycotoxins is of increasing public health concerns. Deoxynivalenol (DON), a mycotoxin contaminating cereals, has been associated with the exacerbation inflammatory bowel diseases (IBD), thereby raising question its role in development IBD. Moreover, effect DON on colon poorly described. Methods and Results Wistar rats exposed (1–4 weeks) to low doses (2 or 9 mg kg −1 feed) show microscopic alterations colonic tissue (dilated lymphatic vessels, luminal...