A5034909064- Optical measurement and interference techniques
- Calcium Carbonate Crystallization and Inhibition
- Image Processing Techniques and Applications
- Bone Tissue Engineering Materials
- Advanced Surface Polishing Techniques
- Metal and Thin Film Mechanics
- Marine Biology and Environmental Chemistry
- Polymer composites and self-healing
- Phase Change Materials Research
- Cellular and Composite Structures
- Advanced Optical Sensing Technologies
- Advanced Measurement and Metrology Techniques
- Granular flow and fluidized beds
- Surface Roughness and Optical Measurements
- Flame retardant materials and properties
- Advanced machining processes and optimization
- Adhesion, Friction, and Surface Interactions
- Digital Holography and Microscopy
- Advanced Materials and Mechanics
- RNA Research and Splicing
- High-Energy Particle Collisions Research
- Transcranial Magnetic Stimulation Studies
- Machine Learning in Materials Science
- Elasticity and Wave Propagation
- Planetary Science and Exploration
Zhejiang University of Technology
2021-2025
Southeast University
2018-2023
Fudan University
2023
State Key Laboratory of Medical Neurobiology
2023
University of Washington
2020
Zhongda Hospital Southeast University
2015-2017
Hong Kong University of Science and Technology
2016
University of Hong Kong
2016
BGI Group (China)
2013
Evidence demonstrates that brain-derived neurotrophic factor (BDNF) has a pivotal role in the pathogenesis of major depressive disorder (MDD). Precursor-BDNF (proBDNF) and mature BDNF (mBDNF) have opposing biological effects neuroplasticity, tissue-type plasminogen activator (tPA)/plasmin system is crucial cleavage processing proBDNF to mBDNF. However, very little known about tPA-BDNF pathway MDD. We examined serum protein concentrations pathway, including tPA, BDNF, tropomyosin receptor...
ABSTRACT Instrumented indentation combined with the classic Oliver–Pharr method has been widely utilized to measure elastic modulus of various materials. However, measured by instrumented spherical (ISI) is not as accurate that sharp indentation, especially at large depth. In this work, effect maximum depth on measurement ISI was deeply investigated through finite element simulations and experiments. It found errors in moduli increase significantly due inaccurate estimation contact radius...
Abstract Although, surface roughness can influence the determination of elastic moduli and indentation hardness to some extent by instrumented spherical test, limited work has been done quantitatively reveal minimize these influences. In present work, through a large number finite element (FE) simulations analyses, we clarified evolution trend determined corresponding different normalized depths ( h / R ) S q ). On this basis, an area correction method was proposed improve measurement...
Alternative pre-mRNA splicing plays critical roles in brain development. SRSF10 is a factor highly expressed central nervous system and important maintaining normal functions. However, its role neural development unclear. In this study, by conditional depleting progenitor cells (NPCs) vivo vitro, we found that dysfunction of leads to developmental defects the brain, which manifest as abnormal ventricle enlargement cortical thinning anatomically, well decreased NPCs proliferation weakened...
Fish scales serve as a dermal armor that provides protection from physical injury. Due to number of outstanding properties, fish are inspiring new concepts for layered engineered materials and next-generation flexible armors. While past efforts have primarily focused on the structure mechanical behavior ontogenetic scales, structure-property relationships regenerated received limited attention. In present study, common carp (Cyprinus carpio) acquired wild were held live in an aquatic...
Abstract Microencapsulated phase change materials (MPCMs) are usually subjected to internal pressure caused by core volume changes or external mechanical stress during service. It is of great importance for individual microcapsule achieve good performance be effective in avoiding the leakage material and providing crucial protection environment. Here, n‐octadecane was selected as different amounts titanium dioxide (TiO 2 ) nanoparticles were added into melamine formaldehyde (MF) shell,...
A panoramic dual-directional shearography system is proposed to simultaneously determine out-of-plane deformation derivatives in two directions and globally inspect the object be tested. dichroic filter (DF), a 3CCD camera, dual-wavelength light are used configuration. The coupled with corresponding imaging sensors of camera provides independent color signals shearograms. Through adjustment tilted stereo-angle DF, which offers second wavelength-dependent measurement, an additional...
Electronic speckle pattern interferometry (ESPI), a well-established technique for micro-deformation measurement, can be used to determine both in-plane and out-of-plane displacement components. Although many works in ESPI have been reported three-dimensional (3D) few focused on the simultaneous measurement of 3D deformation fields. Here we present an system that consists three sub-interferometers all components strain A 3CCD color camera, specially designed shifting stage, lasers with...
Fish scales are dermal armors with an attractive combination of resistance to puncture and flexibility. Past work has attributed this unique quality their composition the hierarchical stratification microstructure. Here, we show that ridge lines circuli contribute overall damage tolerance play a key role in "protectoflexibility" fish scales. Through application optical mechanics, channel along paths reduce effective stress intensity available for bulk fracture Furthermore, comparison line...
A simple and effective phase-shift device is designed for the simultaneous high-accuracy measurement of three-dimensional (3D) deformation using tri-wavelength electronic speckle pattern interferometry a three-sensor charge-coupled camera. The phase-shifter can provide lasers quasi-π / 2 phase-step simultaneously. Multi-component phases related to 3D information are extracted by 90 deg step 4-frame technique from separated red, green, blue channels color images. Six derivative components...
Abstract The compressive mechanical property of thin‐walled hollow spheres structure is researched by experiment and finite element method in this paper. Due to the ideal elastic‐plastic material extremely thin but uniform wall thickness, Ping‐Pong balls are bonded together with a linking neck comprise model structure. experimental result validates effectiveness model. effects geometry parameters then investigated method. results reveal that: 1) deformation process two‐ball bonding includes...
The time-averaged electronic speckle pattern interferometry (ESPI) is employed to measure the frequencies and mode shapes of thin, cantilevered plates with root-slit. first 12 order linear resonance frequency shape an intact plate determined by using FEM calculation. dynamic response specimen forced a PZT actuator measured its super-harmonic investigated experimentally. results show that principal vibration similar natural modal. In contrast forcing vibration, threshold force for much higher...
Finding the prediction factors for risks of post-stroke depression (PSD) is important to stroke survivors. However, most existing studies focused only on general clinical data, which limited predictive ability. To improve ability, this study proposed a comprehensive PSD risk model with social psychological factors, neurological, cognitive functional and factors. The recruited 188 patients. Patients were diagnosed by DSM-IV criteria. Predictors collected within week after stroke. Boosted...
Electronic speckle pattern interferometry (ESPI) has been frequently used to study vibration characteristics of engineering structures. However, efficient ESPI methods for identifying the transparent membranes are rarely reported. A convenient approach determine resonant frequencies and modes films is proposed. quasi-common-path (QCP-ESPI) developed detect out-of-plane deformation visualize vibrational a vibrating diaphragm. An amplitude-modulation-based method proposed quick accurate...