A5039085965- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Cancer Treatment and Pharmacology
- Microscopic Colitis
- Health Systems, Economic Evaluations, Quality of Life
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Venous Thromboembolism Diagnosis and Management
- Acute Lymphoblastic Leukemia research
- Sepsis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hematological disorders and diagnostics
- Histone Deacetylase Inhibitors Research
- Pneumonia and Respiratory Infections
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
Michigan Medicine
2017-2024
University of Michigan
2017-2022
Michigan Cancer Research Consortium
2018
Virginia Commonwealth University
2018
Creative Research Enterprises (United States)
2017
The incidence of Clostridium difficile infection (CDI) in adults with malignancy is 7%-14% compared 1%-2% the general hospitalized population. Despite increased CDI this population, a major concern propensity to recur, leading delays therapy impacting outcomes. We conducted retrospective case-control study identify risk factors for recurrent (rCDI) and determine impact rCDI on adult patients haematological malignancy.Adult haematology from June 2010 December 2014 were divided into two...
Introduction Lymphodepleting chemotherapy (LDC) is critical to CAR T-cell expansion and efficacy. Despite this, there not a consensus in the literature regarding optimal LDC regimen, including dose frequency. Methods We retrospectively reviewed consecutive patients at single institution that received prior treatment with CD19 directed products axicabtagene ciloleucel tisagenlecleucel. Patients treated our center fludarabine 30 mg/m 2 cyclophosphamide 500 for 3 days May 2019. After this...
Abstract Objective: To evaluate whether incorporating mandatory prior authorization for Clostridioides difficile testing into antimicrobial stewardship pharmacist workflow could reduce in patients with alternative etiologies diarrhea. Design: Single center, quasi-experimental before-and-after study. Setting: Tertiary-care, academic medical center Ann Arbor, Michigan. Patients: Adult and pediatric admitted between September 11, 2019 December 10, were included if they had an order placed 1 of...
CYP3A5 and CYP3A4 are the predominant enzymes responsible for tacrolimus metabolism; however only a proportion of population expresses secondary to genetic variation. is expressed in both intestine liver has been shown impact bioavailability metabolism orally administered tacrolimus. Increasing initial dose by 50% 100% recommended patients who known expressers; however, whether this adjustment appropriate i.v. administration unclear. The objective study was evaluate genotype as well other...
Abstract Background Current literature has demonstrated the utility of MRSA nasal screen as a de‐escalation tool to decrease unnecessary anti‐MRSA antibiotic therapy. However, data on applicability this test in patients with hematologic malignancy is lacking. Methods This single‐center, retrospective cohort study acute myeloid leukemia (AML) or without history hematopoietic cell transplant (HCT), pneumonia and screening respiratory cultures obtained. The primary outcome was determine...
Abstract Background Although chimeric antigen receptor T cells (CAR-T) is a promising novel therapy for the treatment of relapsed or refractory (R/R) B-cell malignancies, data on infectious complications associated with this are limited. Therefore, further assessment infections after CAR-T warranted. Methods We retrospectively reviewed and analyzed 6 months following infusion (CTI) in 39 adult pediatric patients R/R acute lymphoblastic leukemia (ALL) Non-Hodgkin Lymphoma (NHL) at Michigan...
The shift from infusion to oral oncolytic therapy presents challenges oncology practitioners. purpose of this study was describe how a statewide quality-improvement collaborative can enhance quality care for patients receiving therapy.The Michigan Oncology Quality Consortium hosted series learning sessions focused on improvement, providing multiple resources community practices. first five participating practices reported which the evidence-based provided were implemented at their site. They...