A5048680588- Fungal and yeast genetics research
- Advanced Electron Microscopy Techniques and Applications
- Enzyme Structure and Function
- Nuclear Structure and Function
- Photosynthetic Processes and Mechanisms
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Protein Structure and Dynamics
- Machine Learning in Healthcare
- Microbial Metabolic Engineering and Bioproduction
- RNA Research and Splicing
- Electron and X-Ray Spectroscopy Techniques
- RNA and protein synthesis mechanisms
- Genetic Neurodegenerative Diseases
- Radioactive element chemistry and processing
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- DNA Repair Mechanisms
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- VLSI and Analog Circuit Testing
- Diatoms and Algae Research
- Neurosurgical Procedures and Complications
- CCD and CMOS Imaging Sensors
- Boron and Carbon Nanomaterials Research
QB3
2012-2019
University of California, San Francisco
2009-2019
Rockefeller University
2018
Sandia National Laboratories California
2009-2011
Sandia National Laboratories
2009
Goodyear (United States)
2006
The 21-subunit Mediator complex transduces regulatory information from enhancers to promoters, and performs an essential role in the initiation of transcription all eukaryotes. Structural on two-thirds has been limited coarse subunit mapping onto 2-D images electron micrographs. We have performed chemical cross-linking mass spectrometry, combined results with X-ray crystallography, homology modeling, cryo-electron microscopy by integrative modeling approach determine a 3-D model entire...
Abstract Building models of a biological system that are consistent with the myriad data available is one key challenges in biology. Modeling structure and dynamics macromolecular assemblies, for example, can give insights into how systems work, evolved, might be controlled, even designed. Integrative modeling casts building structural as computational optimization problem, which information about assembly encoded scoring function evaluates candidate models. Here, we describe our open source...
The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation one proposed mechanism, which hemorrhages grow "domino" fashion via secondary shearing neighboring vessel segments. Hemorrhages were simulated by creating an initial site primary bleeding and associated risk rupture at adjacent sites that decayed over time. Under particular combinations parameters likelihood...
We have measured the neutron energy spectrum of an <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">241</sup> Am-Be(α,n) source between 1.5 MeV and 9 using a scatter camera. The apparatus consists two segmented planes each with 16 liquid scintillator cells (Eljen EJ-309), for total 32 elements; is double elastic events. After unfolding resolution effects maximum likelihood technique, measurement compared to reference Am-Be spectra. Further, we...
Health insurance companies cover half of the United States population through commercial employer-sponsored health plans and pay 1.2 trillion US dollars every year to medical expenses for their members. The actuary underwriter roles at a company serve assess which risks take on how price those ensure profitability organization. While Bayesian hierarchical models are current standard in industry estimate risk, interest machine learning as way improve upon these existing methods is increasing....
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Summary Cryo-electron microscopy (cryo-EM) has become a mainstream technique for determining the structures of complex biological systems. However, accurate integrative structural modeling been hampered by challenges in objectively weighing cryo-EM data against other sources information due to presence random and systematic errors, as well correlations, data. To address these challenges, we introduce Bayesian scoring function that efficiently accurately ranks alternative models...
A Monte Carlo model has been developed for the Sandia Neutron Scatter Camera. We have used this to optimize cell geometry and detector efficiency. The simulations improve understand response calibrations.
We have successfully ruggedized and deployed a field portable fast-neutron imager. Detection efficiency has been increased by > 5x more over the one fielded last year. Imaging demonstrated though 30 cm thick concrete at stand-off distance of 75 m in air. also imaged pulsed D-D neutron generator recorded its energy spectrum. These demonstrations show that our scatter camera could be useful tool not only lab but as detector for hidden SNM.
Health insurance companies cover half of the United States population through commercial employer-sponsored health plans and pay 1.2 trillion US dollars every year to medical expenses for their members. The actuary underwriter roles at a company serve assess which risks take on how price those ensure profitability organization. While Bayesian hierarchical models are current standard in industry estimate risk, interest machine learning as way improve upon these existing methods is increasing....